XL092 and Cemiplimab in BRAF WT Thyroid Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

June 3, 2025

Primary Completion Date

March 31, 2028

Study Completion Date

August 31, 2028

Conditions
Anaplastic Thyroid CancerThyroid CancerBRAF Mutation-Related Tumors
Interventions
BIOLOGICAL

Cemiplimab

Cemiplimab will be administered at a dose of 350mg intravenous over 30 minutes every 3 weeks for 3 cycles (cycle length is 21 days) at weeks 1, 4, and 7.

DRUG

XL092

XL092 will be administered at a dose of 100mg PO daily for 8 weeks (weeks 1-8)

Trial Locations (2)

27599

RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

02215

NOT_YET_RECRUITING

Dana Farber/Harvard Cancer Center, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

collaborator

Exelixis

INDUSTRY

lead

UNC Lineberger Comprehensive Cancer Center

OTHER