Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

1,274

Participants

Timeline

Start Date

December 14, 2021

Primary Completion Date

June 28, 2030

Study Completion Date

June 28, 2030

Conditions
Renal Cell CarcinomaMetastatic Castration-resistant Prostate CancerUrothelial CarcinomaSolid TumorHepatocellular CarcinomaNon-small Cell Lung CancerColorectal CancerHead and Neck Squamous Cell Carcinoma
Interventions
DRUG

Zanzalintinib

Zanzalintinib orally once daily (qd)

DRUG

Nivolumab

360 mg IV infusion once every 3 weeks (q3w)

DRUG

Ipilimumab

1 mg/kg IV infusion once every 3 weeks (q3w) for maximum of four doses

DRUG

Nivolumab

3 mg/kg IV infusion once every 3 weeks (q3w) for first four doses, and then 480 mg IV infusion once every 4 weeks (q4w)

DRUG

Nivolumab

480 mg IV infusion once every 4 weeks (q4w)

DRUG

Nivolumab + Relatlimab

IV administration of nivolumab + relatlimab

Trial Locations (122)

1020

Exelixis Clinical Site #29, Vienna

1023

Exelixis Clinical Site #30, Grafton

1070

Exelixis Clinical Site #39, Anderlecht

1090

Exelixis Clinical Site #106, Wein

2065

Exelixis Clinical Site #42, Saint Leonards

2109

Exelixis Clinical Site #36, Sydney

2640

Exelixis Clinical Site #116, Albury

3204

Exelixis Clinical Site #45, Hamilton

4102

Exelixis Clinical Site #16, Brisbane

4575

Exelixis Clinical Site #35, Birtinya

5020

Exelixis Clinical Site #31, Salzburg

7000

Exelixis Clinical Site #21, Chur

8036

Exelixis Clinical Site #94, Graz

8401

Exelixis Clinical Site #44, Winterthur

8500

Exelixis Clinical Site #37, Kortrijk

9007

Exelixis Clinical Site #22, Sankt Gallen

10032

Exelixis Clinical Site #60, New York

10065

Exelixis Clinical Site #6, New York

13210

Exelixis Clinical Site #76, Syracuse

13273

Exelixis Clinical Site #92, Marseille

14076

Exelixis Clinical Site #79, Caen

15212

Exelixis Clinical Site #32, Pittsburgh

15232

Exelixis Clinical Site #24, Pittsburgh

17033

Exelixis Clinical Site #104, Hershey

19104

Exelixis Clinical Site #98, Philadelphia

19713

Exelixis Clinical Site #49, Newark

20132

Exelixis Clinical Site #101, Milan

20141

Exelixis Clinical Site #81, Milan

21201

Exelixis Clinical Site #14, Baltimore

22763

Exelixis Clinical Site #113, Hamburg

22903

Exelixis Clinical Site #66, Charlottesville

25030

Exelixis Clinical Site #85, Besançon

27710

Exelixis Clinical Site #12, Durham

28033

Exelixis Clinical Site #57, Madrid

28034

Exelixis Clinical Site #43, Madrid

28040

Exelixis Clinical Site #58, Madrid

Exelixis Clinical Site #77, Madrid

28041

Exelixis Clinical Site #19, Madrid

28046

Exelixis Clinical Site #100, Madrid

29572

Exelixis Clinical Site #9, Myrtle Beach

31008

Exelixis Clinical Site #18, Pamplona

32224

Exelixis Clinical Site #78, Jacksonville

32610

Exelixis Clinical Site #11, Gainesville

33000

Exelixis Clinical Site #96, Bordeaux

33136

Exelixis Clinical Site #47, Miami

33322

Exelixis Clinical Site #61, Plantation

33612

Exelixis Clinical Site #8, Tampa

34747

Exelixis Clinical Site #48, Celebration

35042

Exelixis Clinical Site #80, Rennes

37203

Exelixis Clinical Site #3, Nashville

39008

Exelixis Clinical Site #119, Santander

40138

Exelixis Clinical Site #117, Bologna

40202

Exelixis Clinical Site #122, Louisville

41013

Exelixis Clinical Site #23, Seville

44106

Exelixis Clinical Site #10, Cleveland

44625

Exelixis Clinical Site #82, Herne

44805

Exelixis Clinical Site #63, Saint-Herblain

45147

Exelixis Clinical Site #103, Essen

46010

Exelixis Clinical Site #56, Valencia

46026

Exelixis Clinical Site #25, Valencia

46250

Exelixis Clinical Site #4, Indianapolis

48121

Exelixis Clinical Site #74, Ravenna

48201

Exelixis Clinical Site #65, Detroit

48202

Exelixis Clinical Site #13, Detroit

50134

Exelixis Clinical Site #90, Florence

53226

Exelixis Clinical Site #33, Milwaukee

54292

Exelixis Clinical Site #107, Trier

54519

Exelixis Clinical Site #84, Vandœuvre-lès-Nancy

55905

Exelixis Clinical Site #68, Rochester

60020

Exelixis Clinical Site #121, Ancona

60612

Exelixis Clinical Site #26, Chicago

63011

Exelixis Clinical Site #118, Clermont-Ferrand

67200

Exelixis Clinical Site #75, Strasbourg

68130

Exelixis Clinical Site #2, Omaha

Exelixis Clinical Site #5, Omaha

69008

Exelixis Clinical Site #109, Lyon

69120

Exelixis Clinical Site #108, Heidelberg

72076

Exelixis Clinical Site #95, Tübingen

72622

Exelixis Clinical Site #102, Nürtingen

75010

Exelixis Clinical Site #83, Paris

75015

Exelixis Clinical Site #91, Paris

75063

Exelixis Clinical Site #73, Irving

75075

Exelixis Clinical Site #50, Plano

75246

Exelixis Clinical Site #111, Dallas

Exelixis Clinical Site #89, Dallas

75601

Exelixis Clinical Site #70, Tyler

78705

Exelixis Clinical Site #46, Austin

80124

Exelixis Clinical Site #87, Littleton

80131

Exelixis Clinical Site #40, Napoli

81737

Exelixis Clinical Site #112, München

85054

Exelixis Clinical Site #67, Phoenix

85711

Exelixis Clinical Site #1, Tucson

89052

Exelixis Clinical Site #55, Las Vegas

93463

Exelixis Clinical Site #59, Santa Barbara

94304

Exelixis Clinical Site #123, Palo Alto

94805

Exelixis Clinical Site #115, Villejuif

97239

Exelixis Clinical Site #51, Portland

3109601

Exelixis Clinical Site #72, Haifa

4941492

Exelixis Clinical Site #71, Petah Tikva

6423906

Exelixis Clinical Site #69, Tel Aviv

7030000

Exelixis Clinical Site #38, Ẕerifin

8410101

Exelixis Clinical Site #86, Beersheba

9112001

Exelixis Clinical Site #52, Jerusalem

06510

Exelixis Clinical Site #62, New Haven

02215

Exelixis Clinical Site #7, Boston

08816

Exelixis Clinical Site #88, East Brunswick

07601

Exelixis Clinical Site #105, Hackensack

06189

Exelixis Clinical Site #64, Nice

07747

Exelixis Clinical Site #93, Jena

85-796

Exelixis Clinical Site #20, Bydgoszcz

80-219

Exelixis Clinical Site #28, Gdansk

05-400

Exelixis Clinical Site #34, Otwock

60-569

Exelixis Clinical Site #54, Poznan

53-413

Exelixis Clinical Site #114, Wroclaw

06080

Exelixis Clinical Site #41, Badajoz

08035

Exelixis Clinical Site #53, Barcelona

08036

Exelixis Clinical Site #15, Barcelona

08041

Exelixis Clinical Site #27, Barcelona

08908

Exelixis Clinical Site #120, L'Hospitalet de Llobregat

CB2 0QQ

Exelixis Clinical Site #110, Cambridge

W6 8RF

Exelixis Clinical Site #99, London

HA6 2RN

Exelixis Clinical Site #97, Middlesex

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exelixis

INDUSTRY