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Clinical Trials for Agenus
Explore 28 clinical trials worldwide
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Showing 1-28 of 28 trials
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Status: Recruiting, Active, not recruiting, Enrolling by invitation, Not yet recruiting
Sponsor: Agenus
Clinical Trials (28)
NCT07128355
Botensilimab, Balstilimab, and SBRT in Colorectal Cancer
EARLY_PHASE1
Not yet recruiting
15 participants
Started: Jan 31, 2026 · Completed: Sep 30, 2027
1 condition
2 sponsors
1 location
NCT07152821
Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
PHASE3
Not yet recruiting
834 participants
Started: Nov 30, 2025 · Completed: Jun 30, 2029
1 condition
4 sponsors
0 locations
NCT06843551
"The Miami EMPIRE Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation"
PHASE2
Recruiting
20 participants
Started: Jun 18, 2025 · Completed: Aug 1, 2030
2 conditions
2 sponsors
1 location
NCT06782932
Comparing Neoadjuvant/Adjuvant GVAX vs a mKRASvax Given With Anti-PD-1 and Anti-CD137 for Surgically Resectable Pancreatic Cancer
PHASE1/PHASE2
Recruiting
38 participants
Started: May 27, 2025 · Completed: Dec 31, 2028
1 condition
4 sponsors
1 location
NCT06843434
A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma
PHASE2
Recruiting
40 participants
Started: Feb 20, 2025 · Completed: Feb 20, 2028
2 conditions
2 sponsors
7 locations
NCT06076837
The Seven Trial: Exploiting the Unfolded Protein Response
PHASE1
Recruiting
18 participants
Started: Jan 9, 2025 · Completed: Dec 31, 2025
2 conditions
3 sponsors
1 location
NCT06782555
A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab
PHASE1/PHASE2
Recruiting
71 participants
Started: Jan 8, 2025 · Completed: Jan 31, 2028
3 conditions
2 sponsors
1 location
NCT06268015
Botensilimab and Balstilimab Optimization in Colorectal Cancer
PHASE2
Recruiting
15 participants
Started: Nov 18, 2024 · Completed: Jul 31, 2028
1 condition
3 sponsors
1 location
NCT06411691
KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer
PHASE1
Recruiting
54 participants
Started: Nov 4, 2024 · Completed: Nov 1, 2028
2 conditions
5 sponsors
1 location
NCT06346197
Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas
PHASE3
Not yet recruiting
124 participants
Started: Oct 15, 2024 · Completed: May 15, 2028
4 conditions
2 sponsors
1 location
NCT05632328
AGEN1423 and Botensilimab w/ or w/o Chemo in PDAC
PHASE2
Active, not recruiting
24 participants
Started: Aug 8, 2024 · Completed: May 1, 2027
3 conditions
3 sponsors
1 location
NCT06322108
Assessment of the Safety and Efficacy of Balstilimab in Combination With Botensilimab for the Treatment of Non-Small Cell Lung Cancer (IMMONC0008)
PHASE2
Recruiting
45 participants
Started: Jun 13, 2024 · Completed: Apr 30, 2030
1 condition
2 sponsors
1 location
NCT06300463
Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases
PHASE2
Recruiting
24 participants
Started: Mar 26, 2024 · Completed: Mar 31, 2027
3 conditions
2 sponsors
1 location
NCT06095674
ImmunoTHerapy Adjacent to Cervical CAncer (ITHACA) Study
PHASE1
Not yet recruiting
30 participants
Started: Jan 31, 2024 · Completed: Jan 31, 2026
1 condition
3 sponsors
1 location
NCT05864534
Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma
PHASE2
Recruiting
25 participants
Started: Jan 31, 2024 · Completed: Aug 31, 2026
4 conditions
3 sponsors
1 location
NCT06279130
Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations
PHASE2/PHASE3
Recruiting
92 participants
Started: Jan 29, 2024 · Completed: Jan 29, 2034
2 conditions
2 sponsors
1 location
NCT05363709
BALSTILIMAB on Viral Clearance in HPV+ Oropharyngeal Cancer Patients
PHASE2
Recruiting
20 participants
Started: Oct 18, 2023 · Completed: Feb 15, 2028
2 conditions
2 sponsors
1 location
NCT05318469
Ivermectin in Combination With Balstilimab or Pembrolizumab in Patients With Metastatic Triple Negative Breast Cancer
PHASE1/PHASE2
Recruiting
34 participants
Started: Oct 13, 2023 · Completed: Oct 31, 2026
2 conditions
3 sponsors
1 location
NCT05928806
Advanced Renal Cell Cancer Combination ImmunoThErapy Clinical Trial
PHASE2
Recruiting
120 participants
Started: Sep 25, 2023 · Completed: Oct 12, 2026
1 condition
3 sponsors
13 locations
NCT05891821
Assessment of the Safety and Efficacy of Balstilimab for the Treatment of Relapsed/Refractory Lymphomas (IMMONC0001)
PHASE2
Recruiting
20 participants
Started: Sep 1, 2023 · Completed: Sep 30, 2029
1 condition
2 sponsors
1 location
NCT05630183
A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer
PHASE2
Active, not recruiting
81 participants
Started: Mar 27, 2023 · Completed: Dec 5, 2025
1 condition
1 sponsor
36 locations
NCT05529316
A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma
PHASE2
Active, not recruiting
174 participants
Started: Dec 12, 2022 · Completed: Feb 29, 2028
1 condition
1 sponsor
51 locations
NCT05608044
A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer
PHASE2
Active, not recruiting
234 participants
Started: Nov 30, 2022 · Completed: Sep 30, 2029
1 condition
1 sponsor
65 locations
NCT05205330
Vorbipiprant (CR6086) / Balstilimab (AGEN2034) Combination in Stage IV Refractory pMMR - MSS CRC, and Other Metastatic GI Cancers
PHASE1/PHASE2
Recruiting
107 participants
Started: Nov 23, 2021 · Completed: Jun 30, 2027
6 conditions
2 sponsors
3 locations
NCT04827953
Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancer
PHASE1/PHASE2
Active, not recruiting
28 participants
Started: Sep 1, 2021 · Completed: Apr 30, 2025
1 condition
3 sponsors
6 locations
NCT04028063
Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas
PHASE2
Recruiting
65 participants
Started: Jan 28, 2020 · Completed: Nov 30, 2026
2 conditions
2 sponsors
1 location
NCT03894215
RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer
PHASE2
Active, not recruiting
212 participants
Started: Jun 1, 2019 · Completed: Sep 30, 2026
1 condition
2 sponsors
68 locations
NCT03860272
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
PHASE1
Active, not recruiting
499 participants
Started: Mar 20, 2019 · Completed: Dec 31, 2027
8 conditions
1 sponsor
18 locations