234
Participants
Start Date
November 30, 2022
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2029
Botensilimab
An anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody.
Balstilimab
An anti-programmed death (ligand) 1 \[PD-(L)1\] monoclonal antibody.
Standard of Care
Regorafenib or trifluridine and tipiracil.
Antwerp University Hospital (UZA), Edegem
Universitair Ziekenhuis Leuven, Leuven
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
Weill Cornell Medicine, New York
Mount Sinai Hospital - New York, New York
Memorial Sloan Kettering, New York
Institut Paoli-Calmettes, Marseille
Medical Oncology Hematology Consultants, Newark
Fondazione IRCCS Instituto Nazionale dei Tumori, Milan
ASST Grande Ospedale Metropolitano Niguarda, Milan
Virginia Cancer Specialists/NEXT Virginia, Fairfax
Service d'Oncologie Medicale - CHRU Besancon, Besançon
Clínica Universidad de Navarra - Sede Madrid, Madrid
Clínica Universidad de Navarra - Sede Pamplona, Pamplona
Florida Cancer Specialists and Research Institute - Lake Mary, Lake Mary
Istituto Oncologico Veneto-I.R.C.C.S. - Ospedale Busonera, Padua
Tennessee Oncology Nashville (Sarah Cannon), Nashville
Vanderbilt University School of Medicine, Nashville
Hospital Universitario Marques de Valdecilla, Santander
Cleveland Clinic, Cleveland
University of Michigan, Ann Arbor
Hôpital Saint Antoine/AP-HP Hopital Saint Antoine (Pierre and Marie Curie University), Paris
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas
MDACC, Houston
Texas Oncology - Austin Midtown, Austin
Rocky Mountain Cancer Center - Aurora, Aurora
University of Colorado, Denver
HonorHealth Research Institute, Scottsdale
CHU Poitiers - Pole Regional de Cancerologie de Poitiers (PRC), Poitiers
Keck School of Medicine of the University of Southern California, Los Angeles
City of Hope National Medical Center, Duarte
Unversite Paris-Saclay Gustave Roussy Cancer Center Campus Paris, Villejuif
Earle A. Chiles Research Institute - Robert W. Franz Cancer Center - Providence Cancer Institute, Portland
Oregon Health & Science University (OHSU), Portland
Swedish Cancer Institute, Seattle
Northwest Cancer Center Specialists - Vancouver Cancer Center - Compass Oncology Vancouver, Vancouver
"State Budgetary Institution of Healthcare of the City of Moscow Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Health of the City of Moscow", Moscow
Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow
"Branch office of Hadassah Medical Ltd", Moscow
"Clinical Hospital RZD-Medicine of Saint Petersburg", Saint Petersburg
"Federal State Budgetary Institution National Medical Research Center of Oncology named after N.N.Petrov of the Ministry of Health of the Russian Federation", Saint Petersburg
"Napalkov SBHI Saint-Petersburg clinical scientific and practical center for specialised types of medical care (oncological)", Saint Petersburg
"Regional Budgetary Healthcare Institution Kursk Oncological Research and Clinical Center named after G. E. Ostroverkhov", Kursk
"State Budgetary Institution of Health Care Clinical Oncological Dispensary No. 1 of the Ministry of Health of the Krasnodar region", Krasnodar
"Limited Liability Company EVIMED", Chelyabinsk
"Closed Joint Stock Company Medical Center AVICENNA", Novosibirsk
Siberian State Medical University, Tomsk
"BHI of the Omsk region Clinical oncological dispensary", Omsk
"Regional State Budgetary Institution of HealthcareAltai Regional Oncology Dispensary", Barnaul
Beth Israel Deaconess Medical Center, Boston
Dana-Farber Cancer Institute, Boston
Atlantic Health System - Morristown Medical Center, Morristown
Lifespan Clinical Research Center/Cancer Institute (Providence Rhode Island), East Providence
Centro de Pesquisas Clinicas da Fundação Doutor Amaral Carvalho, Jaú
Hospital Sirio Libanes Brasilia, Brasília
Oncosite - Centro de Pesquisa Clinica Em Oncologia, Ijuí
Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre
Instituto Sul Mineiro de Oncologia - ONCOMINAS, Pouso Alegre
Instituto Americas, Rio de Janeiro
Hospital A.C. Camargo Cancer Center, São Paulo
Centro Paulista de Oncologia, São Paulo
High Technology Hospital Medcenter Ltd, Batumi
Innova LLC, Tbilisi
Tbilisi Central Hospital Ltd, Tbilisi
Saint-Petersburg Clinical Research Center of Specialized Types of Medical Care (Oncology), Saint Petersburg
Lead Sponsor
Agenus Inc.
INDUSTRY