Effect of Fruit Elicitation With Melatonin on Human Health

NACompletedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

August 1, 2025

Study Completion Date

August 1, 2025

Conditions
HealthyDietary BioavailabilityPlant ExtractsPhenolic CompoundsMelatonin
Interventions
DIETARY_SUPPLEMENT

Juice from untreated control fruits

Participants will consume 300 g of juice prepared from untreated fruits (lemon, blood orange, or sweet cherry) under fasting conditions on the intervention day. Urine samples will be collected at 0-3.5 h, 3.5-12 h, and 12-24 h post-consumption to assess absorption and metabolism of bioactive compounds.

DIETARY_SUPPLEMENT

Juice from melatonin-treated fruits

Participants will consume 300 g of juice prepared from fruits (lemon, blood orange, or sweet cherry) treated preharvest with melatonin (0.1, 0.3, or 0.5 mM). Juice will be consumed under fasting conditions on the intervention day. Urine samples will be collected at 0-3.5 h, 3.5-12 h, and 12-24 h post-consumption to assess absorption and metabolism of bioactive compounds.

Trial Locations (1)

03312

University Miguel Hernandez, Orihuela

Sponsors
All Listed Sponsors
collaborator

National Research Council, Spain

OTHER_GOV

lead

Universidad Miguel Hernandez de Elche

OTHER