The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF

RecruitingOBSERVATIONAL
Enrollment

120

Participants

Timeline

Start Date

July 10, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
Symptomatic Congestive Heart Failure
Interventions
DEVICE

Cardiac Contractility Modulation (CCM) implant

"Subjects participating in the study carry or will carry the Cardiac Contractility Modulation (CCM) medical device OPTIMIZER Smart Mini by Impulse Dynamics (USA). It is indicated for use in patients over 18 years of age with symptomatic heart failure due to systolic left ventricular dysfunction, despite appropriate medical treatment.~The OPTIMIZER Smart Mini Implantable Pulse Generator is a programmable device with an internal battery and telemetry functions.~The OPTIMIZER Smart Mini is connected to two or three implantable leads, two of which are implanted in the right ventricle and one, optionally, in the right atrium."

Trial Locations (13)

45100

RECRUITING

UO Cardiologia, S. Maria della Misericordia Hospital, ULSS5 Polesana, Rovigo

70131

RECRUITING

UOC Cardiologia con UTIC, Osp. Di Venere, Bari

Unknown

RECRUITING

PO Anastasia Guerriero, Marcianise (CE), UOC Cardiologia, Marcianise

RECRUITING

Clinica Montevergine, Mercogliano (AV), Laboratorio di Elettrofisiologia, Mercogliano

RECRUITING

UOC Cardiologia, Osp. San Rocco, Sessa Aurunca (CE), ASL Caserta, Sessa Aurunca

RECRUITING

Policlinico S.Orsola, UO Cardiologia, Bologna

RECRUITING

OSPEDALE CASTELLI, UO Cardiologia, Anzio

RECRUITING

Elettrofisiologia e Aritmologia, ASST FBF Sacco, Milan

RECRUITING

Fondazione Giglio, Cefalù (PA), UOC Cardiologia, Cefalù

ACTIVE_NOT_RECRUITING

Osp. Generale Provinciale Mazzoni, UO Cardiologia, Ascoli Piceno

RECRUITING

UOC Cardiologia, Osp. Di Mirano, ULSS 3 Serenissima, Mirano

RECRUITING

UOC Cardiologia, Osp. Di Piove di Sacco (PD), ULSS 6 Euganea, Piove di Sacco

RECRUITING

UOC Cardiologia, Osp. S.Bortolo, Vicenza, ULSS 8 Berica, Vicenza

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Impulse Dynamics

INDUSTRY

lead

Quovadis Associazione

OTHER

NCT06973902 - The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF | Biotech Hunter | Biotech Hunter