Implantable Heart Failure Devices
Total Trials
17
As Lead Sponsor
13
As Collaborator
4
Total Enrollment
13,737
NCT00112125
Evaluation of the Safety and Effectiveness of the OPTIMIZER System in Subjects With Heart Failure: FIX-HF-5
Phase: N/A
Role: Lead Sponsor
Start: Feb 28, 2005
Completion: Mar 19, 2019
NCT01381172
Evaluate Safety and Efficacy of the OPTIMIZER® System in Subjects With Moderate-to-Severe Heart Failure: FIX-HF-5C
Start: Jan 31, 2011
NCT02895048
Effects of CCM-therapy in Patients With Heart Failure
Role: Collaborator
Start: Sep 30, 2011
Completion: Nov 30, 2013
NCT02857309
Cardiac Contractility Modulation (CCM) Therapy in Subjects With Medically Refractory Heart Failure
Start: Feb 28, 2014
Completion: Feb 15, 2018
NCT03102437
Continued Access Protocol for the Evaluation of the OPTIMIZER Smart System
Start: Jul 1, 2017
Completion: Dec 16, 2019
NCT03339310
Evaluation of the Safety and Efficacy of the 2-lead OPTIMIZER® Smart System
Start: Oct 23, 2017
Completion: Oct 30, 2019
NCT03240237
CCM in Heart Failure With Preserved Ejection Fraction
Start: May 1, 2018
Completion: Jul 25, 2023
NCT03970343
Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy
Start: Jan 21, 2020
Completion: Mar 1, 2026
NCT04755569
Optimizer System With ODOCOR II CCM™ Leads
Start: Mar 1, 2021
Completion: Dec 31, 2025
NCT05064709
Assessment of CCM in HF With Higher Ejection Fraction
Start: Feb 3, 2022
Completion: Feb 1, 2029
NCT05519046
Cardiac Contractility Modulation in Chagas Heart Disease
Start: May 25, 2022
Completion: Dec 31, 2026
NCT05704426
Arrythmia Burden in Cardiac Contractility Modulation (CCM)
Start: May 1, 2023
Completion: Jul 18, 2023
NCT05855135
Assessment of Combined CCM and ICD Device in HFrEF
Start: May 17, 2023
Completion: Jul 31, 2027
NCT06580392
CCM and Implementation of Guideline-Directed Medical Therapy in Patients With Heart Failure (Fix-GDMT-HF)
Start: Feb 1, 2025
Completion: Dec 31, 2027
NCT06973902
The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF
Start: Jul 10, 2025
Completion: Dec 31, 2028
NCT07112924
CCM OPEN Observational With CCM Therapy for Patients With Heart Failure
Start: Aug 15, 2025
Completion: Aug 1, 2036
NCT07209098
Propensity-Matched Study of Cardiac Contractility Modulation Therapy in Heart Failure
Start: Oct 31, 2025
Completion: Apr 30, 2031
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