A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

984

Participants

Timeline

Start Date

August 7, 2024

Primary Completion Date

September 30, 2026

Study Completion Date

December 31, 2027

Conditions
Diabetic Macular Edema (DME)
Interventions
DRUG

Ranibizumab

Ranibizumab is a commercially available anti-VEGF treatment formulated for intravitreal administration for use in patients with diabetic macular edema

DRUG

EYE103

EYE103 is a humanized antibody formulated for intravitreal administration

Trial Locations (183)

1015

Buenos Aires, Argentina, CABA

1023

Buenos Aires, Argentina, CABA

1090

Vienna, Austria, Vienna

1120

Buenos Aires, Argentina, CABA

1140

Vienna, Austria, Vienna

2000

Santa Fe, Argentina, Rosario

Sydney, Australia, Sydney

Sydney Retina Clinic, Sydney

2135

Sydney, Australia, Sydney

2150

Parramatta, Australia, Parramatta

2640

Albury, Australia, Albury

5000

Cordoba, Argentina, Córdoba

6020

Innsbruck, Austria, Innsbruck

8036

Graz, Austria, Graz

8900

Zalaegerszeg, Hungary, Zalaegerszeg

11572

Oceanside, NY, Oceanside

13008

Marseille, France, Marseille

13088

Liverpool, NY, Liverpool

14620

Rochester, NY, Rochester

15706

Santiago de Compostela, Spain, Santiago de Compostela

16507

Erie, PA, Erie

18017

Bethlehem, PA, Bethlehem

20122

Milano, Italy, Milan

20132

Milano, Italy, Milan

20157

Milano, Italy, Milan

21079

Cedex, France, Dijon

21740

Hagerstown, MD, Hagerstown

23235

Richmond, Virginia, Richmond

24502

Lynchburg, VA, Lynchburg

27103

Winston Salem, NC, Winston-Salem

27587

Wake Forest, MC, Wake Forest

28602

Hickory, NC, Hickory

28803

Asheville, NC, Asheville

29169

West Columbia, SC, West Columbia

29456

Ladson, SC, Ladson

29501

Florence, SC, Florence

29902

Beaufort, SC, Beaufort

30625

Hanover, Germany, Hanover

31000

Osijek, Croatia, Osijek

32308

Tallahassee, FL, Tallahassee

32607

Gainesville, FL, Gainesville

32806

Orlando, Florida, Orlando

33064

Deerfield Beach, FL, Deerfield Beach

33100

Udine, Italy, Udine

33308

Fort Lauderdale, FL, Fort Lauderdale

33324

Plantation, FL, Plantation

33617

Tampa, FL, Tampa

33711

Saint Petersburg, FL, St. Petersburg

33880

Winter Haven, FL, Winter Haven

33912

Fort Myers,FL, Fort Myers

34232

Sarasota, FL, Sarasota

35330

Balcova, Turkey, Balçova

37203

Nashville, TN, Nashville

37343

Hixson, Tennessee, Hixson

37540

Saint Cyr sur Loire, France, Saint-Cyr-sur-Loire

37604

Johnson City, Tennessee, Johnson City

37922

Knoxville, TN, Knoxville

38138

Germantown, TN, Germantown

39110

Madison, MS, Madison

40138

Bologna, Italy, Bologna

41009

Sevilla, Spain, Seville

44122

Cleveland, Ohio, Cleveland

44130

Cleveland, OH, Cleveland

44505

Youngstown, Ohio, Youngstown

46100

Valencia, Spain, Burjassot

48145

Munster, Germany, Münster

49100

Petah Tikva, Israel, Petah Tikva

49546

Grand Rapids, Michigan, Grand Rapids

50009

Zaragoza, Spain, Zaragoza

50016

Medellin, Colombia, Medellín

50021

Medellin, Colombia, Medellín

50139

Firenze, Italy, Florence

50266

West Des Moines, IA, West Des Moines

55435

Minneapolis, MN, Minneapolis

60439

Lemont, IL, Lemont

60590

Frankfurt, Germany, Frankfurt

62702

Springfield, Illinois, Springfield

66215

Lenexa, Kansas, Lenexa

67214

Wichita, Kansas, Wichita

69004

Lyon, France, Lyon

70300

Beer Yakov, Israel, Be’er Ya‘aqov

72703

Fayetteville, Arkansas, Fayetteville

72764

Springdale, Arkansas, Springdale

73013

Edmond, OK, Edmond

75006

Paris, France, Paris

75015

Paris, France, Paris

75019

Paris, France, Paris

75075

Plano, TX, Plano

75231

Dallas, TX, Dallas

76012

Arlington, TX, Arlington

76087

Willow Park, TX, Willow Park

76100

Rehovot, Israel, Rehovot

76104

Fort Worth, TX, Fort Worth

77384

The Woodlands, TX, The Woodlands

77401

Bellaire, TX, Bellaire

77494

Katy, TX, Katy

77707

Beaumont, TX, Beaumont

78154

Schertz, Texas, Schertz

78240

San Antonio, TX, San Antonio

78681

Round Rock, TX, Round Rock

78705

Austin, TX, Austin

79106

Amarillo, TX, Amarillo

79109

Amarillo, TX, Amarillo

79606

Abilene, TX, Abilene

80002

Barranquilla, Colombia, Barranquilla

80210

Denver, Colorado, Denver

80336

Munchen, Germany, München

80909

Colorado Springs, CO, Colorado Springs

84107

Salt Lake City, Utah, Salt Lake City

85255

Scottsdale, Scottsdale

91204

Glendale, CA, Glendale

92374

Redlands, CA, Redlands

92705

Santa Ana, Santa Ana

93309

Bakersfield, CA, Bakersfield

94010

Creteil, France, Créteil

94040

Mountain View, CA, Mountain View

95356

Modesto, CA, Modesto

95825

Sacramento, CA, Sacramento

95841

Sacramento, CA, Sacramento

97221

Portland, OR, Portland

97477

Springfield, Oregon, Springfield

99204

Spokane, WA, Spokane

110231

Bogota, Columbia, Bogotá

760042

Cali, Colombia, Santiago de Cali

3436212

Haifa, Israel, Haifa

6423906

Tel Aviv, Israel, Tel Aviv

9112001

Jerusalem, Israel, Jerusalem

06810

Danbury, CT, Danbury

06042

Manchester, CT, Manchester

06385

Waterford,CT, Waterford

33609-4614

Tampa, FL, Tampa

04101

Portland, Maine, Portland

01107

Springfield,MA, Springfield

07003

Bloomfield, NJ, Bloomfield

08034

Cherry Hill, NJ, Cherry Hill

X5000AAJ

Ciudad de Cordoba, Argentina, Córdoba

C1033AAW

Buenos Aires, Argentina, CABA

C1116ABA

Caba, Buenos Aires, Argentina, Caba

S2000DSK

Santa Fe, Argentina, Rosario

1150/50

Prague, Czechia, Prague

293 01

Mlada Boleslav, Czechia, Mladá Boleslav

547 01

Nachod, Czechia, Náchod

Unknown

Prague, Czechia, Prague

H-1085

Budapest, Hungary, Budapest

H-1062

Budapest, Hungary, Budapest

H-1106

Budapest, Hungary, Budapest

H-4032

Debrecen, Hungary, Debrecen

H-1133

Budapest, Hungry, Budapest

H-7621

Pecs, Hungary, Pécs

H-6720

Szeged, Hungary, Szeged

00168

Roma, Italy, Roma

81.00133

Rome, Italy, Rome

LV1002

Riga, Latvia, Riga

LV1006

Riga, Latvia, Riga

80-809

Gdansk, Poland, Gdansk

Gdansk, Poland, Gdansk

15-866

Bialystok, Poland, Bialystok

85-309

Bydgoszcz, Poland, Bydgoszcz

40-594

Katowice, Poland, Katowice

31-501

Krakow, Poland, Krakow

42-600

Tarnowskie Gory, Poland, Tarnowskie Góry

85-631

Bydgoszcz, Poland, Bydgoszcz

10-424

Olsztyn, Poland, Olsztyn

4200-319

Porto, Portugal, Porto

3000-548

Coimbra, Portugal, Coimbra

3030-163

Coimbra, Portugal, Coimbra

00612

Arecibo, PR, Arecibo

075 01

Trebisov, Slovakia, Trebišov

911 01

Trencin, Slovakia, Trenčín

012 07

Zilina, Slovakia, Žilina

08195

Barcelona, Spain, Barcelona

08021

Barcelona, Spain, Barcelona

08035

Barcelona, Spain, Barcelona

08022

Barcelona, Spain, Barcelona

06230

Ankara, Turkey, Ankara

06490

Ankara, Turkey, Ankara

NW10 7NS

London, UK, London

BD9 6RJ

Bradford, United Kingdom, Bradford

L7 8YA

Liverpool, United Kingdom, Liverpool

SR2 9HP

Sunderland, United Kingdom, Sunderland

WV10 0QP

Wolverhamptom, United Kingdom, Wolverhampton

YO10 4DZ

York, United Kingdom, York

BS1 2LX

Bristol, UK, Bristol

Sponsors

Lead Sponsor

All Listed Sponsors
lead

EyeBiotech Ltd.

INDUSTRY

NCT06571045 - A Study to Evaluate the Efficacy and Safety of 2 Doses of EYE103 Compared With Ranibizumab (0.5 mg) in Participants With DME | Biotech Hunter | Biotech Hunter