A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)

PHASE2RecruitingINTERVENTIONAL
Enrollment

87

Participants

Timeline

Start Date

June 11, 2024

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2027

Conditions
Parkinson Disease
Interventions
DRUG

AAV2-GDNF Gene therapy

Bilateral image-guided infusion of AAV2-GDNF into putamen, single dose

PROCEDURE

Control Surgery

Bilateral partial burr/twist holes without dural penetration

Trial Locations (39)

19104

RECRUITING

University of Pennsylvania (Neurology), Philadelphia

20057

RECRUITING

Georgetown University (Neurology), Washington D.C.

27514

RECRUITING

University of North Carolina (Neurology), Chapel Hill

27705

ACTIVE_NOT_RECRUITING

Duke Neurosurgery (Surgical), Durham

27710

NOT_YET_RECRUITING

Duke University (Neurology), Durham

30322

ACTIVE_NOT_RECRUITING

Emory University (Surgical), Atlanta

33486

RECRUITING

Parkinson's Disease and Movement Disorders Center of Boca Raton (Neurology), Boca Raton

33980

ACTIVE_NOT_RECRUITING

Parkinson's Disease Treatment Center of Southwest Florida (Neurology), Port Charlotte

37232

RECRUITING

Vanderbilt University (Neurology), Nashville

43210

ACTIVE_NOT_RECRUITING

Ohio State University (Surgical), Columbus

48334

RECRUITING

Quest Research Institute (Neurology), Farmington Hills

48824

RECRUITING

Michigan State University (Neurology), East Lansing

53705

RECRUITING

University of Wisconsin (Neurology), Madison

60612

NOT_YET_RECRUITING

Rush University Medical Center (Neurology), Chicago

66103

RECRUITING

University of Kansas Medical Center (Neurology), Kansas City

77030

RECRUITING

Houston Methodist (Neurology), Houston

ACTIVE_NOT_RECRUITING

Houston Methodist (Surgical), Houston

80113

RECRUITING

CenExel Rocky Mountain Clinical Research (Neurology), Englewood

89106

NOT_YET_RECRUITING

Cleveland Clinic Lou Ruvo (Neurology), Las Vegas

92354

RECRUITING

Loma Linda University (Neurology), Loma Linda

ACTIVE_NOT_RECRUITING

Loma Linda University (Surgical), Loma Linda

92697

NOT_YET_RECRUITING

UCI Alpha Clinic (Neurology), Irvine

94143

RECRUITING

University of California San Francisco (Neurology), San Francisco

ACTIVE_NOT_RECRUITING

University of San Francisco (Surgical), San Francisco

98034

NOT_YET_RECRUITING

EvergreenHealth Research Department (Neurology), Kirkland

02114

RECRUITING

Massachusetts General Hospital (Neurology), Boston

ACTIVE_NOT_RECRUITING

Massachusetts General Hospital (Surgical), Boston

Unknown

ACTIVE_NOT_RECRUITING

Charité - Universitätsmedizin Berlin (Surgical), Berlin

RECRUITING

Philipps-Universität Marburg (Neurology), Marburg

RECRUITING

Universitätsklinikum Tübingen (Neurology), Tübingen

ACTIVE_NOT_RECRUITING

Universitätsklinikum Tübingen (Surgical), Tübingen

RECRUITING

Universitätsklinikum Würzburg (Neurology), Würzburg

RECRUITING

Copernicus Podmiot Leczniczy, Szpital św. Wojciecha (Neurology), Gdansk

RECRUITING

Specjalistyczna Praktyka Lekarska Prof. Grzegorz Opala (Neurology), Katowice

RECRUITING

Mazowiecki Szpital Bródnowski (Neurology), Warsaw

ACTIVE_NOT_RECRUITING

Mazowiecki Szpital Bródnowski (Surgical), Warsaw

RECRUITING

Samodzielny Publiczny Szpital Kliniczny im. Prof. W. Orłowskiego CMKP (Neurology), Warsaw

RECRUITING

North Bristol NHS Trust - Southmead Hospital (Neurology), Bristol

ACTIVE_NOT_RECRUITING

University Hospital of Wales (Surgical), Cardiff

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

AskBio Inc

INDUSTRY