Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

344

Participants

Timeline

Start Date

January 29, 2024

Primary Completion Date

April 29, 2026

Study Completion Date

September 27, 2027

Conditions
Neovascular Age-Related Macular Degeneration
Interventions
DRUG

OTX-TKI (axitinib implant)

Intravitreal Injection of OTX-TKI (axitinib implant)

DRUG

Aflibercept

Injection of 2mg (0.05mL) of aflibercept

Trial Locations (108)

612

Emanuelli research and development, Arecibo

1121

Centro Oftalmologico Dr. Charles S.A, Buenos Aires

11788

Long Island Vitreoretinal Consultants (VRC) - Hauppauge, Hauppauge

11967

NY LIVRC Long Island Vitreoretinal Consultants, Shirley

13088

Retina-Vitreous Surgeons of Central New York, Liverpool

16507

Erie Retina Research, Erie

21287

The Wilmer Eye Institute, Baltimore

21740

Cumberland Valley Retina Consultants, Hagerstown

24019

Vistar Eye Center Vision and Surgery Specialists, Roanoke

27705

Duke University Health System - Duke Eye Center Of North Durham, Durham

28803

Asheville Eye Associates (AEA) - Retinal Office, Asheville

29414

Charleston Neuroscience Institute LLC - Charleston, Charleston

29456

Charleston Neuroscience Institute, Ladson

29464

Retina Consultants of Charleston - Mount Pleasant, Mt. Pleasant

29501

Palmetto Retina Center, Florence

29802

Palmetto Retina Center, Aiken

29902

Charleston Neuroscience Institute LLC - Beaufort, Beaufort

SC CNI Retina Consultants of Charleston, Beaufort

33064

Rand Eye Institute, Deerfield Beach

Speciality Retina Center, Deerfield Beach

33143

MedEye Associates - Miami, South Miami

33145

South Florida Retina Institute, Miami

33607

Retina Vitreous Associates of Florida - Tampa, Tampa

33609

Retina Associates of Florida LLC Tampa MacDill, Tampa

33761

The Macula Center - Clearwater Office (Suncoast Retina Consultants, LLC), Clearwater

33805

Florida Retina Consultants - Lakeland, Lakeland

44122

Retina Associates of Cleveland, Inc. - Beachwood, Beachwood

44130

Retina Associates of Cleveland, Cleveland

44505

Retina Associates of Cleveland, Inc. - Youngstown, Youngstown

46290

IN AVRUC Associated Vitreoretinal and Uveitis Consultants, Carmel

48073

Associated Retinal Consultants P.C. (ARC) - Royal Oak, Royal Oak

48202

Henry Ford Hospital, Detroit

54403

Eye Clinic of Wisconsin, Wausau

55435

Retina Consultants of Minnesota, Edina

57108

Vance Thompson Vision, Sioux Falls

60452

University Retina and Macula Associates, P.C., Oak Forest

60612

Illinois Eye and Ear Infirmary at UI Health UIC, Chicago

62703

Springfield Clinic, Springfield

63017

Pepose Vision Institute, Chesterfield

76028

Star Vision Consultants, Burleson

77030

Texas Retina Center, Houston

77384

Retina Consultants of Houston, The Woodlands

77401

Retina Group, Inc. d/b/a Retina Consultants of America (Retina Consultants of Texas), Bellaire

77494

Retina Consultants of Texas - Katy, Katy

77707

Retina Consultants of Texas Beaumont, Beaumont

78240

Retinal Consultants of Texas - San Antonio Medical Center, San Antonio

TX RCTX Retina Consultants of Texas, San Antonio

78731

Keystone Research, Austin

79606

West Texas Retina Consultants (WTRC) - Abilene (Ophthalmology Specialists of Texas, PA), Abilene

80210

RSC Research, PLLC, Denver

80228

Colorado Retina Associates (CRA) - Lakewood, Lakewood

80909

Retina Consultants of Southern Colorado - Colorado Springs, Colorado Springs

85020

Associated Retina Consultants - Phoenix, Phoenix

85053

Retinal Research Institute, Phoenix

85255

Retina Macula Institute of Arizona, Scottsdale

85297

Associated Retina Consultants - Gilbert, Gilbert

90505

Macula Retina Vitreous Center, Torrance

91105

Doheny Eye Center, Pasadena

91107

AzulVision, Pasadena

91436

The Retina Partners - Encino, Encino

92604

Lakeside Vision Center - Irvine, Irvine

92647

Atlantis Eyecare, Huntington Beach

92705

Orange County Retina Medical Group, Santa Ana

92835

Retina Consultants of Orange County - Fullerton, Fullerton

93103

CA CRC California Retina Consultants, Bakersfield

CA CRC California Retina Consultants, Oxnard

94303

Stanford University School of Medicine, Byers Eye Institute, Palo Alto

94598

Bay Area Retina Associates, A Medical Group, Walnut Creek

94611

Kaiser Permanente Division of Research, Oakland

95356

CA RCMG Retinal Consultants Medical Group, Inc., Modesto

Retina Sacramento MSO, LLC, Modesto

90017-4886

Retina-Vitreous Associates Medical Group - Los Angeles, Los Angeles

93103-4211

California Retina Consultants (CRC) - Santa Barbara, Santa Barbara

06385

Retina Group of New England, PC, Waterford

33308-1909

Retina Group of Florida - Fort Lauderdale, Fort Lauderdale

32746-2175

Florida Retina Institute - Lake Mary, Lake Mary

32503-2030

Retina Specialty Institute - Pensacola, Pensacola

33711-1141

Retina Vitreous Associates of Florida (RVA) - Saint Petersburg, St. Petersburg

30909-6440

Southeast Retina Center, P.C. - Augusta, Augusta

60657-7227

Illinois Retina Associates, S.C. - Lincoln Park, Chicago

46290-1166

Retina Partners Midwest, Indianapolis

50266-7705

Wolfe Eye Clinic, West Des Moines

04101-2438

Maine Eye Center - Marginal Way Campus, Portland

21740-5846

Mid Atlantic Retina Specialists - Hagerstown, Hagerstown

39202-2064

Mississippi Baptist Medical Center, Jackson

63144-1317

Retina Research Institute, LLC, St Louis

89502-1605

Sierra Eye Associates, Reno

07003

The Retina Center Of New Jersey, LLC - Bloomfield, Bloomfield

29169-2429

Palmetto Retina Center, West Columbia

57701-7374

Black Hills Regional Eye Institute (BHREI), Rapid City

38138-2405

Charles Retina Institute PC, Germantown

37203-1596

Tennessee Retina, PC - Nashville - Centennial Professional Plaza Location, Nashville

76012-2505

Texas Retina Associates (TRA) - Arlington, Arlington

78705-1023

Retina Consultants of Austin PA (RCA) - Central Austin, Austin

78705-1169

Austin Retina Associates, PLLC, Austin

78750-2302

Retina Research Center (RRC), Austin

78240-1502

Medical Center Ophthalmology Associates (MCOA) - Northwest Clinic Location, San Antonio

84107-6767

Retina Associates of Utah, P.C - Intermountain Medical Center Location, Salt Lake City

23502-3933

Wagner Macula & Retina Center - Norfolk, VA Office, Norfolk

B1629AHJ

Buenos Aires Macula, Pilar

C1015

Organizacion Medica de Investigacion OMI, Buenos Aires

C1023AAQ

Fundacion Zambrano - Cirugia Ocular, Buenos Aires

C1120AAN

Instituto Oftalmologico de Alta Complejidad, Buenos Aires

S2000

Oftalmologia Global, Rosario

X5000AAI

Centro Privado de Ojos Romagosa SA, Córdoba

M5500GGK

Oftar Mendoza Srl Centro Privado de Oftalmologia, Mendoza

M5500

Centrovision, Mendoza

S2126DTO

Laser Vision Group, Santa Fe

Sponsors
All Listed Sponsors
collaborator

Fortrea

INDUSTRY

collaborator

Duke University

OTHER

lead

Ocular Therapeutix, Inc.

INDUSTRY