IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

PHASE3RecruitingINTERVENTIONAL
Enrollment

680

Participants

Timeline

Start Date

June 5, 2024

Primary Completion Date

October 16, 2027

Study Completion Date

October 16, 2027

Conditions
Advanced Melanoma
Interventions
DRUG

Brenetafusp

Soluble PRAME-specific T cell receptor with anti-CD3 scFV concentrate for solution for intravenous (IV) infusion at a unit dose of 0.2 mg/mL.

DRUG

Nivolumab

Concentrate for solution for infusion at a unit dose of 10 mg/mL.

DRUG

Nivolumab + Relatlimab

Concentrate for solution for infusion at a unit dose of 16 mg/mL.

Trial Locations (174)

1085

RECRUITING

Semmelweis Egyetem Általános Orvostudományi Kar, Budapest

1090

RECRUITING

Universitair Ziekenhuis Brussel, Brussels

1140

RECRUITING

Medical Park Seyhan Hastanesi, Seyhan

1200

RECRUITING

Cliniques Universitaires Saint-Luc - Institut Roi Albert II, Brussels

1213

RECRUITING

Sanatorio Finochietto, Caba

1527

RECRUITING

University Hospital Tsaritsa Yoanna (ISUL) (Queen Giovanna University Hospital), Sofia

2730

RECRUITING

Kobenhavns Universitet - Herlev Hospital (Amtssygehuset i Herlev), Herlev

3051

RECRUITING

Peter MacCallum Cancer Centre, North Melbourne

3084

RECRUITING

Austin Hospital, Heidelberg

4000

RECRUITING

Complex Oncology Center - Plovdiv Ltd., Plovdiv

4103

RECRUITING

Universitaetsklinikum Leipzig - Klinik fuer Dermatologie, Venerologie und Allergologie, Leipzig

4120

COMPLETED

Gallipoli Medical Research Foundation (Greenslopes Private Hospital), Greenslopes

4500

RECRUITING

Uni Hospital, Panagyurishte

5020

RECRUITING

Paracelsus Medizinischen Privatuniversitaet - SALK - Universitaetsklinik fuer Dermatologie - EB-Haus Austria, Salzburg

6100

RECRUITING

T.C. Saglik Bakanligi - SBU Gulhane Egitim ve Arastirma Hastanesi, Ankara

6230

RECRUITING

Kanser Enstitusu (Hacettepe University Cancer Institute), Altındağ

6720

RECRUITING

Szegedi Tudomanyegyetem (University of Szeged), Szeged

6800

RECRUITING

Ankara Bilkent City Hospital, Oncology Department, Çankaya

7624

RECRUITING

Pecsi Tudomanyegyetem (PTE) (University of Pecs), Pécs

8000

RECRUITING

AZ Sint-Jan Brugge-Oostende AV-Campus Sint-Jan, Bruges

8036

RECRUITING

LKH - Universitaetsklinikum Graz, Graz

RECRUITING

Hospital Clinic de Barcelona, Barcelona

8901

RECRUITING

UniversitaetsSpital Zuerich - Dermatologische Klinik, Zurich

10032

COMPLETED

Columbia University Medical Center, New York

10115

RECRUITING

Charite-Universitaetsmedizin Berlin - Campus Charite Mitte (CCM) - Klinik fuer Dermatologie Venerologie und Allergologie - Hauttumorcentrum Charite (HTCC), Berlin

10126

RECRUITING

Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino, Torino

11042

RECRUITING

Northwell Health Cancer Institute, Lake Success

13385

RECRUITING

Hôpital de la Timone, Marseille

13875

RECRUITING

Azienda Sanitaria Locale di Biella (ASL BI) - Ospedale degli Infermi, Ponderano

14000

RECRUITING

UNICANCER-Centre Francois Baclesse (CFB), Caen

14004

RECRUITING

Hospital Universitario Reina Sofia, Córdoba

14784

RECRUITING

Fundacao Pio XII - Hospital de Cancer de Barretos - Hospital de Amor, Barretos

15006

RECRUITING

Complejo Hospitalario Universitario A Coruna (CHUAC), A Coruña

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

18014

RECRUITING

Hospital Universitario Virgen de las Nieves (HUVN), Granada

19107

RECRUITING

Thomas Jefferson University, Philadelphia

20007

RECRUITING

Georgetown University, Washington D.C.

20133

RECRUITING

Fondazione IRCCS - Istituto Nazionale dei Tumori - Milano, Milan

20141

RECRUITING

Istituto Europeo di Oncologia (IEO) (European Institute of Oncology), Milan

20246

RECRUITING

University of Hamburg, Hamburg

22045

RECRUITING

Elbe Kliniken Stade - Hautkrebszentrum Buxtehude, Hamburg

22185

RECRUITING

Skanes Universitetssjukhus - Lund - Onkologiska Klinik, Lund

22903

RECRUITING

UVA Health-UVA Emily Couric Clinical Cancer Center, Charlottesville

24125

RECRUITING

Humanitas Gavazzeni (Cliniche Gavazzeni S.p.A), Bergamo

26000

RECRUITING

Hopital Robert Debre, Valence

27584

RECRUITING

Medical Park Gaziantep Hastanesi, Şehitkamil

28009

RECRUITING

Hospital General Universitario Gregorio Marañon, Madrid

28027

RECRUITING

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid, Madrid

28034

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

28041

RECRUITING

Universidad Complutense de Madrid (UCM)-Hospital Universitario 12 de Octubre (H12O), Madrid

28046

RECRUITING

Hospital Universitario La Paz, Madrid

28050

RECRUITING

Centro Integral Oncologico Clara Campal (CIOCC), Madrid

29016

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

29303

RECRUITING

Spartanburg Regional Healthcare System - Spartanburg Medical Center (SMC), Spartanburg

29605

RECRUITING

Prisma Health Cancer Institute, Greenville

30120

RECRUITING

Universidad de Murcia - Hospital Universitario Virgen de la Arrixaca (HUVA), El Palmar

31008

RECRUITING

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona, Pamplona

31059

RECRUITING

Oncopole Claudius Regaud- Institut Universitaire du Cancer de Toulouse, Toulouse

32224

RECRUITING

Mayo Clinic Florida, Jacksonville

32429

RECRUITING

Johannes Wesling Klinikum Minden, Minden

33136

RECRUITING

University of Miami Health System-Sylvester Comprehensive Cancer Center-Miami, Miami

34180

RECRUITING

Memorial Saglik Grubu - Memorial Bahcelievler Hastanesi, Bahçelievler

35100

RECRUITING

Ege Universitesi Tip Fakultesi (Ege University Faculty of Medicine), Bornova

35128

RECRUITING

Istituto Oncologico Veneto (IOV) IRCCS, Padua

35575

RECRUITING

Izmir Ekonomi Universitesi Medikal Point Hastanesi, Cordaleo

37203

RECRUITING

Sarah Cannon Research Institute: USA/TN, Nashville

39008

RECRUITING

Universidad de Cantabria (UC) - Hospital Universitario Marques de Valdecilla (HUMV), Santander

41009

RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

41017

RECRUITING

St. Elizabeth Healthcare - Edgewood, Edgewood

44280

RECRUITING

Inonu Universitesi - Turgut Ozal Tip Merkezi, Malatya

45122

RECRUITING

Universitaetsklinikum Essen, Essen

46010

RECRUITING

Instituto de Investigacion Sanitaria (INCLIVA) (Institute of Health Research Hospital Clinic of Valencia), Valencia

46014

RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

46026

RECRUITING

Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia

47014

RECRUITING

"IRCCS Istituto Scientifico Romagnolo per lo Studio dei Tumori Dino Amadori Srl (IRST)", Meldola

50009

RECRUITING

Servicio Aragones de Salud - Hospital Universitario Miguel Servet (HUMS), Zaragoza

53100

RECRUITING

" Azienda Ospedaliera Universitaria Senese - Policlinico Santa Maria Alle Scotte - Clinica Immunoterapia Oncologica", Siena

55270

RECRUITING

Ondokuz Mayis Universitesi (OMU) - Tip Facultesi, Samsun

59037

RECRUITING

Centre Hospitalier Universitaire de Lille (CHU Lille)-Hopital Claude Huriez, Lille

60185

COMPLETED

Centrum Medyczne Pratia Poznań - Skorzewo, Skorzewo

60590

RECRUITING

Johann Wolfgang Goethe-Universitaet Frankfurt am Main - Klinik fuer Dermatologie, Venerologie und Allergologie, Frankfurt

60611

RECRUITING

Northwestern University - Robert H. Lurie Comprehensive Cancer Center - NMDTI, Chicago

63110

COMPLETED

Washington University School of Medicine, St Louis

66205

RECRUITING

The University of Kansas Cancer Center (KUCC) - Westwood, Westwood

69120

RECRUITING

Universitaetsklinikum Heidelberg (UKHD) - Hautklinik, Heidelberg

69310

RECRUITING

Hospices Civils de Lyon (HCL) - Centre Hospitalier Lyon-Sud, Pierre-Bénite

70124

RECRUITING

Istituto Tumori Giovanni Paolo II - Ospedale Oncologico di Bari, Bari

72076

RECRUITING

Universitaetsklinikum Tuebingen (UKT) - Zentrum fuer Dermatoonkologie - Hautklinik, Tübingen

75010

RECRUITING

Hospital Saint Louis, Paris

76031

RECRUITING

Centre Hospitalier Universitaire de Rouen (CHU de Rouen) - Hopital Charles-Nicolle, Rouen

77900

RECRUITING

Fakultni Nemocnice Olomouc (FNOL), Olomouc

80045

RECRUITING

University of Colorado, Anschutz Medical Campus, Aurora

80131

RECRUITING

"Istituto Nazionale Tumori (INT) Fondazione G. Pascale di Napoli", Napoli

81377

RECRUITING

LMU Klinikum - Klinik und Poliklinik fur Dermatologie und Allergologie, Munich

84112

RECRUITING

University of Utah Huntsman Cancer Institute, Salt Lake City

85720

RECRUITING

University of Arizona, Tucson

85796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Łukaszczyka, Bydgoszcz

90025

RECRUITING

The Angeles Clinic and Research Institute- West Los Angeles, Los Angeles

90033

RECRUITING

ESC Norris Comprehensive Cancer Center, Los Angeles

90095

RECRUITING

UCLA Hematology/Oncology, Los Angeles

90404

RECRUITING

Saint John's Health Center - John Wayne Cancer Institute (JWCI), Santa Monica

92104

RECRUITING

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Ambroise-Pare, Boulogne-Billancourt

93000

RECRUITING

Assistance Publique-Hopitaux de Paris (AP-HP) - Hopitaux Universitaires Paris Seine-Saint-Denis - Hopital Avicenne, Bobigny

94304

RECRUITING

Stanford Cancer Institute - Stanford Cancer Center Palo Alto, Palo Alto

94800

RECRUITING

Institut Gustave Roussy (IGR) Service de Dermatolgie, Villejuif

97080

RECRUITING

Universitaetsklinikum Wuerzburg - Klinik und Poliklinik fuer Dermatologie Venerologie und Allergologie, Würzburg

98104

RECRUITING

Swedish Medical Center - Swedish Cancer Institute (SCI) - First Hill Campus, Seattle

99089

RECRUITING

Helios Klinikum Erfurt - Klinik fuer Hautkrankheiten und Allergologie, Erfurt

200542

RECRUITING

Sf Nectarie Oncology Center, Craiova

400015

RECRUITING

L'Institute Oncologique Prof. Dr. Ion Chiricuta (IOCN) (The Oncology Institute Prof. Dr. Ion. Chiricuta), Cluj-Napoca

700106

RECRUITING

Victoria Hospital (Centrul de oncologie Euroclinic SRL) (Centrul De Oncologie Medicala) (Euroclinic Onchology Center), Iași

92093-0698

RECRUITING

University of California - San Diego, La Jolla

06030-2205

RECRUITING

UConn Health-Farmington (University of Connecticut Health Center (UCHC)), Farmington

02215

RECRUITING

Dana Farber Cancer Institute, Boston

07601

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

C1430EGF

RECRUITING

Clínica Adventista Belgrano - Sector Investigación, Caba

CP1426ANZ

RECRUITING

Instituto Alexander Fleming, CABA

X5008HHW

RECRUITING

CEMAIC (Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba

R8500ACE

RECRUITING

Clinica Viedma, Viedma

02298

RECRUITING

Calvary Mater Newcastle Hospital, Waratah

06009

RECRUITING

Linear Clinical Research, Nedlands

RECRUITING

One Clinical Research - Nedlands, Nedlands

Unknown

RECRUITING

University of Sydney - Melanoma Institute Australia (MIA) - The Poche Centre, Wollstonecraft

RECRUITING

The University of Queensland (UQ) - Princess Alexandra Hospital (PAH), Woolloongabba

RECRUITING

Universitätsklinikum St. Pölten, Pölten

RECRUITING

Regina Life Clinic, Sofia

RECRUITING

CHU de Dijon Bourgogne - Hôpital François Mitterrand, Dijon

RECRUITING

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes

01070

RECRUITING

Universite Libre de Bruxelles (ULB)-Institut Jules Bordet, Anderlecht

03000

RECRUITING

UZ Leuven, Leuven

98700-000

RECRUITING

Centro de Pesquisa Clinica em Oncologia - Oncosite, Ijuí

90110-270

RECRUITING

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa Ltda, Porto Alegre

DF CEP 70200-730

RECRUITING

Hospital Sirio-Libanes (HSL) - Centro de Oncologia - Brasilia, Brasília

88034-000

RECRUITING

Centro de Pesquisas Oncologicas (CEPON), Florianópolis

60135-237

RECRUITING

Oncocentro Sao Carlos Hospital, Fortaleza

01509-010

RECRUITING

A.C.Camargo Cancer Center - Centro Internacional de Pesquisa (CIPE), Liberdade

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre

90610-000

RECRUITING

Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) - Hospital Sao Lucas - Centro de Pesquisa Clinica (CPC), Porto Alegre

20220-410

RECRUITING

National Cancer Institute, Rio de Janeiro

22775-001

RECRUITING

Instituto Américas - Instituto de Educação Pesquisa e Gestão em Saúde Oncosite, Rio de Janeiro

01246-000

RECRUITING

Instituto do Cancer do Estado de Sao Paulo (ICESP), São Paulo

01308-070

RECRUITING

Hospital 9 de Julho, São Paulo

15090-000

RECRUITING

Faculdade de Medicina de Sao Jose do Rio Preto-SP (FAMERP) - Hospital de Base (HB) - Centro Integrado de Pesquisa (CIP), São Paulo

M5G 2C1

RECRUITING

Princess Margaret Cancer Centre, Toronto

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

500 05

RECRUITING

Fakultni Nemocnice Hradec Kralove (FNHK) - Klinika Onkologie a Radioterapie, Hradec Králové

110 00

RECRUITING

Sanatorium Profesora Arenbergera, Prague

01307

RECRUITING

Universitätsklinikum Carl Gustav Carus, Dresden

D-35392

RECRUITING

Justus-Liebig-Universitaet Giessen - Klinik fuer Dermatologie und Andrologie, Giessen

I-35128

RECRUITING

Istituto Oncologico Veneto (IOV) IRCCS, Padua

06129

RECRUITING

Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia, Perugia

00128

RECRUITING

National Cancer Institute Regina Elena, Roma

0168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

05009

RECRUITING

Haukeland University Hospital, Bergen

0379

RECRUITING

Oslo University Hospital, Oslo

80-214

RECRUITING

Klinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne, Gdansk

02-781

RECRUITING

Klinika Nowotworów Tkanek Miękkich, Kości i Czerniaków, Warsaw

08035

RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

RECRUITING

Hospital Universitario Dexeus, Barcelona

08908

RECRUITING

Hospital Duran i Reynals, Barcelona

SE41345

RECRUITING

Sahlgrenska Akademin - Institutionen for Kliniska Vetenskaper (Institute of Clinical Sciences), Gothenburg

553 05

RECRUITING

Lanssjukhuset Ryhov - Onkologiska Kliniken, Jönköping

171 76

RECRUITING

Karolinska Universitetssjukhuset, Stockholm

SE75185

RECRUITING

Uppsala Universitet - Akademiska Sjukhuset (Uppsala University Hospital), Uppsala

06520

RECRUITING

Memorial Saglik Grubu - Memorial Ankara Hastanesi, Çankaya

07070

RECRUITING

Medical Park Hastaneler Grubu - I.A.U. VM Medical Park Florya, Antalya

06170

RECRUITING

T.C. Saglik Bakanligi - Ankara Etlik sehir Hastanesi, Yenimahalle

CB20QQ

RECRUITING

Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital (AH) - Oncology Centre, Cambridge

G12 0YN

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

L78YA

RECRUITING

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

W1G 6AD

RECRUITING

Sarah Cannon Research Institute (SCRI) - London (SCRI-UK), London

M204BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

SM2 5PT

RECRUITING

Royal Marsden Hospital - Sutton, Surrey Quays

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Immunocore Ltd

INDUSTRY

NCT06112314 - IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301) | Biotech Hunter | Biotech Hunter