A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale

PHASE3TerminatedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

August 26, 2022

Primary Completion Date

July 27, 2023

Study Completion Date

July 27, 2023

Conditions
Parkinson Disease
Interventions
DRUG

BIIB122

Administered as specified in the treatment arm.

DRUG

BIIB122-Matching Placebo

Administered as specified in the treatment arm.

Trial Locations (27)

1307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

8035

Hospital Universitari Vall d'Hebron, Barcelona

8036

Hospital Clinic de Barcelona, Barcelona

8190

Hospital General de Catalunya, Sant Cugat del Vallès

10003

Mount Sinai Beth Israel, New York

10021

Weill Medical College of Cornell University, New York

13385

Hôpital de la Timone, Marseille

19107

Pennsylvania Hospital, Philadelphia

20014

Hospital Universitario Donostia, Donostia / San Sebastian

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

31059

Hopital Purpan, Toulouse

33486

Parkinson's Disease and Movement Disorders Center, Boca Raton

33613

USF Health Byrd Institute, Tampa

35033

CHU Rennes - Hopital Pontchaillou, Rennes

38003

Hospital Universitario Marques de Valdecilla, Santander

41013

Hospital Universitario Virgen del Rocio, Seville

66160

University of Kansas Medical Center Research Institute, Inc., Kansas City

69500

Centre Hospitalier Universitaire de Lyon-Hospices Civils de Lyon-Hopital Pierre Wertheimer, Bron

72076

Universitaetsklinikum Tuebingen, Tübingen

75013

Groupe Hospitalier Pitie-Salpetriere, Paris

80045

University of Colorado, Aurora

80113

Rocky Mountain Movement Disorders Center, PC, Englewood

94143

University of California San Francisco (UCSF), San Francisco

98034

Evergreen Hospital Medical Center, Kirkland

99202

Inland Northwest Research, Spokane

02114

Massachusetts General Hospital, Boston

DD1 9SY

Ninewells Hospital, Dundee

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Denali Therapeutics Inc.

INDUSTRY

lead

Biogen

INDUSTRY