A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

416

Participants

Timeline

Start Date

August 24, 2022

Primary Completion Date

May 14, 2026

Study Completion Date

January 8, 2029

Conditions
Mild Cognitive Impairment Due to Alzheimer's DiseaseAlzheimer's Disease Dementia
Interventions
DRUG

BIIB080

Administered as specified in the treatment arm.

DRUG

BIIB080-matching placebo

Administered as specified in the treatment arm.

Trial Locations (138)

185

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Roma

1090

UZ Brussel, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

1205

Hôpitaux Universitaires de Genève - HUG- Centre de la mémoire, Bâtiment A1 - Morier, Geneva

2010

St Vincent's Hospital Sydney, Darlinghurst

2050

Royal Prince Alfred Hospital, Camperdown

2100

Rigshospitalet, Copenhagen

2170

Liverpool Hospital, Liverpool

2217

Southern Neurology, Kogarah

2501

Spitalzentrum Biel, Biel/Bienne

3000

UZ Leuven, Leuven

4101

Mater Hospital Brisbane, South Brisbane

4600

Klinikum Altenburger Land GmbH, Altenburg

6903

Ospedale Regionale di Lugano, Lugano

8025

Hospital de la Santa Creu i Sant Pau, Barcelona

8028

Fundacio ACE, Barcelona

8036

Hospital Clinic de Barcelona, Barcelona

8500

AZ Groeninge, Kortrijk

9007

Kantonsspital St. Gallen, Sankt Gallen

9100

Ålborg Universitets Hospital, Aalborg

10016

New York University Medical Center PRIME, New York

10117

Charité - Campus Charité Mitte, Berlin

11772

South Shore Neurologic Associates, P.C., Patchogue

12208

Neurological Associates of Albany, PC, Albany

13125

Charité - Universitätsmedizin Berlin, Berlin

13210

SUNY Upstate Medical University, Syracuse

14004

Hospital Universitario Reina Sofia, Córdoba

14186

Karolinska universitetssjukhuset - Huddinge, Stockholm

14226

Dent Neurologic Institute, Amherst

16000

FORBELI s.r.o., Prague

20132

Ospedale San Raffaele, Milan

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

20520

CRST, Clinical Research Services Turku, Turku

25123

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia

25198

Hospital Universitari de Santa Maria, Lleida

27710

Duke University, Durham

28105

AMC Research, LLC, Matthews

31008

Clinica Universidad de Navarra, Pamplona

31059

Hopital Purpan, Toulouse

Hôpital La Grave, Toulouse

32159

Charter Research, LLC, Lady Lake

32751

K2 Medical Research, LLC, Orlando

32789

Conquest Research, Winter Park

32792

Charter Research, LLC, Winter Park

32804

Advent Health, Orlando

34295

Hopital Gui de Chauliac, Montpellier

36071

Ospedale di Arzignano, Arzignano VI

37075

Universitaetsmedizin Goettingen, Göttingen

38018

Neurology Clinic, PC, Cordova

40568

Care Clinic Centrum Medyczne, Katowice

41009

Hospital Victoria Eugenia, Seville

43180

Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus, Mölndal

44718

NeuroScience Research Center, LLC., Canton

44791

Katholisches Klinikum Bochum gGmbH, Bochum

44800

CHU Nantes - Hopital Nord Laënnec, Saint-Herblain

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

48993

CAE Oroitu, Getxo

50005

Fakultni nemocnice Hradec Kralove, Hradec Králové

50937

Universitaetsklinikum Koeln, Cologne

53127

Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE), Bonn

59037

Hopital Roger Salengro - CHU Lille, Lille

64711

Neuro Centrum Science GmbH, Erbach im Odenwald

65691

Fakultni nemocnice u sv. Anny v Brne, Brno

67000

CHU Strasbourg - Hôpital Hautepierre, Strasbourg

68167

Universitaetsmedizin Mannheim, Mannheim

70210

Itä-Suomen yliopisto, Kuopion kampus, Kuopio

70852

Fakultni nemocnice Ostrava, Ostrava

72076

Universitaetsklinikum Tuebingen, Tübingen

73039

Azienda Ospedaliera Card. G. Panico, Tricase

75010

Hôpital Lariboisière, Paris

75013

Groupe Hospitalier Pitie-Salpetriere, Paris

75243

Neurology Consultants of Dallas, PA, Dallas

76031

CHU de Rouen - Hôpital Charles Nicolle, Rouen

78229

University of Texas Health Science Center at San Antonio, San Antonio

80113

Rocky Mountain Movement Disorders Center, PC, Englewood

81377

Klinikum der Universität München, München

85004

Xenoscience Inc., Phoenix

85251

HonorHealth Neurology, Scottsdale

85351

Banner Sun Health Research Institute, Sun City

85718

Center for Neurosciences, Tucson

89081

Universitaetsklinikum Ulm, Ulm

90015

Fondazione Istituto G.Giglio di Cefalù, Cefalù

90095

Mary S. Easton Center for Alzheimer's Disease Research, UCLA, Los Angeles

92103

University of California San Diego Medical Center, San Diego

92868

PNS Clinical Research, LLC dba, Orange

94143

University of California San Francisco (PARENT), San Francisco

94304

Stanford Hospital and Clinics, Palo Alto

95445

Klinikum Bayreuth GmbH- Hohe Warte, Bayreuth

95816

Sutter Institute for Medical Research, Sacramento

96817

Hawaii Pacific Neuroscience, Honolulu

98034

EvergreenHealth, Kirkland

99202

Kingfisher Cooperative, LLC, Spokane

02115-5804

Brigham and Women's Hospital Department of Neurology, Boston

02216

Beth Israel Deaconess Medical Center, Boston

01805

Lahey Clinic Medical Center - Burlington, Burlington

02459

Boston Center for Memory, Newton

45206-0829

University of Cincinnati Physicians Group, LLC, Cincinnati

02906

Butler Hospital, Providence

V2C 5T1

The Medical Arts Health Research Group, Kamloops

V6T 2B5

UBC Hospital, Vancouver

V7T 1C5

Medical Arts Health Research Group, West Vancouver

K1Z 1G3

Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic, Ottawa

M3B 2S7

Toronto Memory Program (Neurology Research Inc.), Toronto

J8T 8J1

Clinique de la Memoire de l'Outaouais, Gatineau

H3A 2B4

Montreal Neurological Institute Clinical Research Unit, Montreal

H3T 1E2

Jewish General Hospital - NETWORK, Montreal

150 06

Fakultni nemocnice v Motole, Prague

516 01

Vestra Clinics s.r.o., Rychnov nad Kněžnou

06156

Azienda Ospedaliera e Universitaria di Perugia, Perugia

791-0295

Ehime University Hospital, Toon-shi

672-8043

Himeji Central Hospital Clinic, Himeji-shi

211-8533

Nippon Medical School Musashi Kosugi Hospital, Kawasaki-shi

231-8682

Yokohama City Minato Red Cross Hospital, Yokohama

545-8586

Osaka Metropolitan University Hospital, Osaka

565-0871

Osaka University Hospital, Suita-shi

173-0015

Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku

Amsterdam

Brain Research Center Amsterdam, Amsterdam

15-756

Podlaskie Centrum Psychogeriatrii, Bialystok

85-133

PROMENTE Sp. z o.o., Bydgoszcz

40-650

Nzoz Novo-Med, Katowice

30-688

SPZOZ Szpital Uniwersytecki w Krakowie, Krakow

92-213

SPZOZ Centralny Szpital Kliniczny UM w Lodzi, Lodz

20-954

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Kliniczny Oddział Neurologii Oddział Udarowy, Lublin

81-855

Centrum Medyczne Senior, Sopot

01-684

NeuroProtect Sp. z o.o., Warsaw

03-242

Mazowiecki Szpital Wojewódzki w Warszawie Sp z oo, Warsaw

SE5 8AF

Institute of Psychiatry, Psychology and Neuroscience, London

W1G 9RU

Re:Cognition Health Ltd (London), London

W6 8RF

Charing Cross Hospital, London

WC1N 3BG

The National Hospital for Neurology and Neurosurgery Centre, London

M13 9WL

Greater Manchester Mental Health NHS Foundation Trust, Manchester

SO16 6YD

Southampton General Hospital, Southampton

OX3 7JX

Warneford Hospital, Oxford

S10 2JF

Royal Hallamshire Hospital, Sheffield

ML1 4UF

NeuroClin Limited, Motherwell

B16 8LT

Re:Cognition Health - Birmingham, Birmingham

BS32 4SY

Re Cognition Health Bristol, Bristol

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY