A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Parkinson's Disease in Adults Between the Ages of 30 and 80

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

650

Participants

Timeline

Start Date

April 19, 2022

Primary Completion Date

February 25, 2026

Study Completion Date

March 9, 2026

Conditions
Parkinson Disease
Interventions
DRUG

BIIB122

Administered as specified in the treatment arm

DRUG

BIIB122-Matching Placebo

Administered as specified in the treatment arm

Trial Locations (113)

1160

Klinik Ottakring, Vienna

6020

Medizinische Universität, Innsbruck

8036

Hospital Clinic de Barcelona, Barcelona

10003

Mount Sinai Beth Israel, New York

10021

Weill Medical College of Cornell University, New York

13005

Hôpital de la Timone, Marseille

15006

Complejo Hospitalario Universitario A Coruña, A Coruña

19107

UPHS, Philadelphia

20014

Policlinica Gipuzkoa, Donostia / San Sebastian

20122

Fondazione, Milan

20132

Ospedale San Raffaele, Milan

23298

Virginia Commonwealth University Department of Neurology, Richmond

23538

Universitaetsklinikum Schleswig-Holstein - Campus Luebeck, Lübeck

25123

Azienda Ospedaliera Spedali, Brescia

27705

Duke Movement Disorders Clinic, Durham

28006

Hospital Universitario de La Princesa, Madrid

29425

Medical University of South Carolina, Charleston

30625

Medizinische Hochschule Hannover, Hanover

31008

Clinica Universidad de Navarra, Pamplona

31059

Hopital Purpan, Toulouse

32803

Adventist Health System/Sunbelt, Inc., Orlando

33136

University of Miami, Miami

33486

Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton

33613

USF Health Byrd Institute, Tampa

34128

Paracelsus-Elena-Klinik Kassel, Kassel

34295

Hopital Gui de Chauliac, Montpellier

35033

CHU Rennes - Hopital Pontchaillou, Rennes

35043

Philipps University of Marburg, Marburg

38003

Hospital Universitario Marques, Santanda

38018

Neurology Clinic, PC, Cordova

40139

IRCCS-Institute of Neurological Sciences of Bologna, Bologna

40225

Universitaetsklinikum Duesseldorf AoeR, Düsseldorf

41013

Hospital Universitario Virgen del Rocio, Seville

44093

CHU Nantes - Hopital Nord Laën, Loire-Atlantique

44195

The Cleveland Clinic Foundation, Cleveland

44791

Katholisches Klinikum Bochum gGmbH, Bochum

48334

Quest Research Institute, Farmington Hills

48903

Hospital de Cruces, Barakaldo

56126

AO Universitaria Pisana, Pisa

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

63003

CHU Clermont Ferrand - Hopital Gabriel Montpied, Clermont-Ferrand

66100

Ospedale Clinicizzato SS. Annu, Chieti

66160

University of Kansas Medical Center Research Institute, Inc., Kansas City

69500

Centre Hospitalier Universitaire de Lyon-Hospices Civils de Lyon-Hopital Pierre Wertheimer, Bron

72076

Universitaetsklinikum Tuebingen, Tübingen

75013

Groupe Hospitalier Pitie-Salpetriere, Paris

77030

The Methodist Hospital Research Institute, Houston

78681

Central Texas Neurology Consultants, Round Rock

80045

University of Colorado, Aurora

80113

CenExel Rocky Mountain Clinical Research, Englewood

80138

AOU Luigi Vanvitelli, Napoli

81377

Klinikum der Universität München, Munich

81675

Klinikum rechts der Isar der TU Muenchen, Munich

85054

Mayo Clinic Arizona, Phoenix

85351

Banner Sun Health Research Institute, Sun City

86077

I.R.C.C.S. Neuromed, Diego

89081

Universitaetsklinikum Ulm, Ulm

90033

University of Southern California, Los Angeles

90048

Cedars Sinai, Los Angeles

91105

SC3 Research Group Inc., Pasadena

94010

Hopital Henri Mondor, Paris

94143

University of California San Francisco (UCSF), San Francisco

95123

Azienda Ospedaliero Universitaria Policlinico 'Gaspare Rodolico - San Marco' (Presidio G. Rodolico), Catania

96817

Hawaii Pacific Neuroscience, LLC, Honolulu

97080

Universitaetsklinikum Wuerzburg, Würzburg

98034

Evergreen Hospital Medical Center, Kirkland

99202

Inland Northwest Research, Spokane

100053

Xuanwu Hospital Capital Medical University, Beijing

100730

Beijing Hospital, Beijing

215004

Second Affiliated Hospital of Soochow University, Jiangsu

610041

West China Hospital, Sichuan University, Chengdu

4941492

Rabin Medical Center, Petah Tikva

5262000

Center Chaim Sheba Medical Center, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

06510

Invicro, New Haven

02118

Boston University Medical Center, Boston

02215

Beth Israel Deaconess Medical Center, Boston

02421

Massachusetts General Hospital, Boston

T2N 1N4

University of Calgary, Calgary

B3S 1M7

True North Clinical Research, Halifax

M5T 2S8

Toronto Western Hospital, Toronto

H2L 4M1

CHUM Centre de Recherche, Montreal

H3A 2B4

Montreal Neurological Institute, Montreal

01307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

00163

IRCCS San Raffaele Pisana, Roma

901-1105

Okinawa Prefectural Nanbu, Haeburu

530-8480

Tazuke-kofukai Medical Research Institute Kitano Hospital, Osaka

070-8644

NHO Asahikawa Medical Center, Asahikawa-shi

672-8043

Himeji Central, Himeji-shi

982-8555

Sendai Nishitaga National Hospital, Sendai

113-8431

Juntendo University, Tokyo

1081 GN

Brain Research Center Amsterdam, Amsterdam

6525 GA

Radboudumc, Nijmegen

8025 AZ

Brain Research Center Zwolle B.V., Zwolle

32-600

Instytut Zdrowia dr Boczarska-Jedynak sp.z.o.o, Sp.K, Oświęcim

01-684

NeuroProtect Sp. z o.o., Warsaw

85-163

Centrum Medyczne Neuromed, Bydgoszcz

40-650

Nzoz Novo-Med, Katowice

02-699

INSULA Centrum Badan Klinicznych, Warsaw

03-505

MD Clinic Praga, Warsaw

'08190

Hospital General de Catalunya, Sant Cugat del Vallès

08035

Hospital Universitari Vall d'Hebron, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

PL6 8DH

University Hospitals Plymouth, Plymouth

W1G 9RU

Re:Cognition Health Ltd (London), London

W6 8RF

Charing Cross Hospital, London

WC1N 3BG

The National Hospital for Neurology & Neurosurgery, London

M6 8HD

Salford Royal NHS Foundation Trust, Salford

ML1 4UF

NeuroClin Limited, Motherwell

NE4 5PL

Newcastle University, Newcastle upon Tyne

B16 8LT

Re:Cognition Health - Birmingham, Birmingham

DD1 9SY

Ninewells Hospital, Dundee

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Denali Therapeutics Inc.

INDUSTRY

lead

Biogen

INDUSTRY