A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,027

Participants

Timeline

Start Date

June 2, 2022

Primary Completion Date

August 12, 2024

Study Completion Date

August 12, 2024

Conditions
Alzheimer's Disease
Interventions
DRUG

Aducanumab

Administered as specified in the treatment arm.

DRUG

Placebo

Administered as specified in the treatment arm.

Trial Locations (265)

1090

Universitair Ziekenhuis Brussel, Brussels

1307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

2010

St Vincent's Hospital Sydney, Darlinghurst

2113

KaRa Institute of Neurological Diseases, Macquarie Park

3000

UZ Leuven, Leuven

3004

The Alfred Hospital, Melbourne

3050

Royal Melbourne Hospital, Parkville

3084

Austin Health, Heidelberg

3103

Health Pharma Professional Research S.A. de C.V., Mexico City

3128

Box Hill Hospital, Box Hill

3199

Frankston Hospital, Frankston

5030

Konkuk University Medical Center, Seoul

5505

Asan Medical Center, Seoul

6009

Australian Alzheimer's Research Foundation, Nedlands

6156

Azienda Ospedaliera e Universitaria di Perugia, Perugia

8000

AZ Sint-Jan, Bruges

8500

AZ Groeninge, Kortrijk

10016

New York University Medical Center PRIME, New York

10029

Mount Sinai, New York

10314

Richmond Behavioral Associates ERG Clinical Research - New York PLLC, Staten Island

10591

IMA Evaluations LLC, Tarrytown

11235

Social Psychiatry Research Institute (SPRI), Brooklyn

11772

South Shore Neurologic Associates, P.C., Patchogue

11794

Stony Brook University Hospital, Stony Brook

12099

NEUROZENTRUM tempelhof.berlin, Berlin

12208

Neurological Associates of Albany, PC, Albany

13125

Charité - Universitätsmedizin Berlin, Berlin

13210

SUNY Upstate Medical University, Syracuse

13385

Hôpital de la Timone, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

14004

Hospital Universitario Reina Sofia, Córdoba

14186

Karolinska Universitetssjukhuset, Stockholm

14226

Dent Neurologic Institute, Amherst

14618

Finger Lakes Clinical Research, Rochester

14642

University of Rochester - PARENT, Rochester

16132

IRCCS Ospedale Policlinico San Martino, Genova

17475

Universitaetsmedizin Greifswald, Greifswald

19001

Abington Neurological Associates, LTD, Abington

19046

The Clinical Trial Center, LLC, Jenkintown

19104

Penn Memory Center, Philadelphia

20009

Policlinica Gipuzkoa, Donostia / San Sebastian

20052

ASST di Monza, Monza

20132

Ospedale San Raffaele, Milan

20520

CRST, Clinical Research Services Turku, Turku

21201

University of Maryland Medical Center, Baltimore

22903

University of Virginia Health System, Charlottesville

23294

National Clinical Research Inc. - Richmond, Richmond

23510

Glennan Center for Geriatrics and Gerontology, Norfolk

25123

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia

25198

Hospital Universitari de Santa Maria, Lleida

27157

Wake Forest Baptist Health Sciences, Winston-Salem

27710

Duke University, Durham

28027

Clinica Universidad de Navarra (MAD), Madrid

28105

AMC Research, LLC, Matthews

29935

Coastal Neurology PA, Port Royal

31008

Clinica Universidad de Navarra, Pamplona

31059

Hôpital La Grave, Toulouse

32127

United Medical Research, Port Orange

32159

Charter Research, LLC, Lady Lake

32714

Neurology of Central Florida Research Center, LLC, Altamonte Springs

32751

K2 Medical Research, LLC, Orlando

K2 Medical Research, Orlando

32819

Headlands Research LLC, Orlando

32832

Conquest Research, Orlando

33024

Infinity Clinical Research, LLC, Hollywood

33064

Quantum Laboratories Inc., Pompano Beach

33076

Groupe Hospitalier Pellegrin - Hôpital Pellegrin, Bordeaux

33165

Medical Research Center, Miami

33428

Neurology Offices of South Florida, PLLC, Boca Raton

33445

Brain Matters Research, Delray Beach

33462

JEM Research Institute, Atlantis

33486

ECommunity Research, LLC, Boca Raton

33607

K2 Medical Research Tampa, Tampa

33613

USF Health Byrd Institute, Tampa

33803

ARS - Lake Oconee, Lakeland

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34209

Nova Clinical Research, LLC, Bradenton

34295

Hopital Gui de Chauliac, Montpellier

34470

Renstar Medical Research, Ocala

34761

K2 Medical Research, LLC, Ocoee

34997

Brain Matters Research, Stuart

35033

CHU Rennes - Pontchaillou, Rennes

36071

Ospedale di Arzignano, Arzignano VI

37075

Universitaetsmedizin Goettingen, Göttingen

37909

Genesis Neuroscience Clinic, Knoxville

38018

Neurology Clinic, PC, Cordova

39120

Universitaetsklinikum Magdeburg, Magdeburg

39401

Hattiesburg Clinic, PA, Hattiesburg

40225

Universitaetsklinikum Duesseldorf AoeR, Düsseldorf

40506

University of Kentucky Medical Center, Lexington

41009

Hospital Victoria Eugenia, Seville

43180

Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus, Mölndal

43210

Ohio State University Medical Center, Columbus

44195

Cleveland Clinic Foundation, Cleveland

44610

Hospital Mexico Americano SC, Guadalara

44720

Neuro-Behavioral Clinical Research, Inc., North Canton

44791

Katholisches Klinikum Bochum gGmbH, Bochum

44800

CHU Nantes - Hopital Nord Laënnec, Saint-Herblain

45417

JY Research Institute, Cutler Bay

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University School of Medicine, Indianapolis

48201

Wayne State University - Detroit Medical Center, Detroit

48334

Michigan Institute for Neurological Disorders, Farmington Hills

50937

Universitaetsklinikum Koeln, Cologne

53127

Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE), Bonn

53226

Medical College of Wisconsin, Inc., Milwaukee

53659

NZOZ Wroclawskie Centrum Alzheimerowskie, Wroclaw

53705

University of Wisconsin-Madison, Madison

54449

Marshfield Clinic, Marshfield

55130

Center for Memory and Aging, Saint Paul

59037

Hopital Roger Salengro - CHU Lille, Lille

60007

Alexian Brothers Medical Center - Neuroscience Research Institute, Elk Grove Village

60528

Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main

60637

Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research, Chicago

University of Chicago Medical Center, Chicago

61350

Zentrum für klinische Forschung Dr.med. Irma Schöll, Bad Homburg

64460

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

64620

Centro de Estudios Clinicos y Especialidades Medicas, S.C., Monterrey

64710

AVIX Investigación Clínica S.C, Monterrey

65721

Sharlin Health and Neurology, Ozark

66205

University of Kansas Medical Center Research Institute, Inc., Fairway

67000

CHU Strasbourg - Hôpital Hautepierre, Strasbourg

67214

Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc., Wichita

68165

ISPG - Institut fuer Studien zur Psychischen Gesundheit, Mannheim

69100

Hôpital des Chapennes, Villeurbanne

70121

Ochsner Health System PARENT, New Orleans

71103

LSU Health Sciences Center Shreveport, Shreveport

72076

Universitaetsklinikum Tuebingen, Tübingen

72703

Health Initiatives Research, Fayetteville

73039

Azienda Ospedaliera Card. G. Panico, Tricase

73112

Lynn Health Science Institute, Oklahoma City

74136

Central States Research, LLC, Tulsa

75010

Hôpital Lariboisière, Paris

75013

Groupe Hospitalier Pitie-Salpetriere, Paris

Hôpital Broca, Paris

75231

Kerwin Medical Center, Dallas

76107

University of North Texas Health Science Center, Fort Worth

77030

Baylor College Of Medicine, Houston

The Methodist Hospital Research Institute, Houston

77074

Clinical Trial Network LLC, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

78526

Headlands Research - Brownsville, Brownsville

78681

Central Texas Neurology Consultants, Round Rock

78757

Senior Adult Specialty Research, Austin

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

80045

University of Colorado Anschutz Medical Campus, Aurora

80138

"Azienda Ospedaliera Universitaria- Università degli Studi della Campania Luigi Vanvitelli", Napoli

81377

Institut fuer Schlaganfall- und Demenzforschung (ISD), Munich

81621

Mountain Neurological Research Center, Basalt

81675

Klinikum rechts der Isar der TU Muenchen, Munich

84131

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona, Salerno

85004

Xenoscience Inc., Phoenix

85006

Banner Alzheimer's Institute, Phoenix

85012

Banner Alzheimer's Institute, Tucson

85013

Barrow Neurological Institute, Phoenix

85251

HonorHealth Neurology, Scottsdale

85259

Mayo Clinic Arizona, Scottsdale

85297

Gilbert Neurology Partners, PLLC, Gilbert

85351

Banner Sun Health Research Institute, Sun City

89106

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas

89113

Las Vegas Medical Research, Las Vegas

90015

Fondazione Istituto G.Giglio di Cefalù, Cefalù

90095

Mary S. Easton Center for Alzheimer's Disease Research, UCLA, Los Angeles

91403

California Neuroscience Research, LLC, Sherman Oaks

92069

The Neuron Clinic, San Marcos

92243

Sun Valley Behaivoral Med Center, El Centro

92374

Anderson Clinical Research, Redlands

92591

Viking Clinical Research Center, Temecula

92614

Irvine Center for Clinical Research, Inc., Irvine

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92705

Syrentis Clinical Research, Santa Ana

92835

Neurology Center of North Orange County, Fullerton

93710

Neuropain Medical Center, Fresno

94115

Sutter Health-San Francisco, San Francisco

94143

University of California San Francisco (PARENT), San Francisco

94304

Stanford Hospital and Clinics, Palo Alto

VA Palo Alto Health Care System, Palo Alto

95445

Klinikum Bayreuth GmbH- Hohe Warte, Bayreuth

96817

Hawaii Pacific Neuroscience, Honolulu

97239

Oregon Health & Science University (OHSU), Portland

98109

University of Washington Medical Center, Seattle

99202

Kingfisher Cooperative, LLC, Spokane

06824

Yale University, Fairfield

06510

Institute for Neurodegenerative Disorders (IND), New Haven

06511

Yale University School Of Medicine, New Haven

06851

Research Center for Clinical Studies, Inc., Norwalk

20060-0002

Howard University Health Sciences, Washington D.C.

02478

McLean Hospital, Belmont

02115-5804

Brigham and Women's Hospital Department of Neurology, Boston

02215

Beth Israel Deaconess Medical Center, Boston

01844

ActivMed Practices and Research, Methuen

02459

Boston Center for Memory, Newton

02360

Donald S. Marks, M.D., P.C., Plymouth

68198-3285

University of Nebraska Medical Center, Omaha

07081

The Cognitive Research Center of New Jersey, Springfield

08755

CenExel Advanced Memory Research Institute of NJ, Toms River

02915-2237

Rhode Island Hospital, East Providence

02915

Rhode Island Mood & Memory Research Institute, East Providence

02906

Butler Hospital, Providence

75390-8896

UT Southwestern Medical Center, Dallas

05201

The Memory Clinic, Bennington

80240-280

Trial Tech Tecnologia em Pesquisas com Medicamentos Ltda, Curitiba

81210-310

Instituto de Neurologia de Curitiba - Hospital Ecoville, Curitiba

90110-000

IMV Pesquisa Neurologica Sociedade Simples Ltda, Porto Alegre

90610-000

Instituto do Cerebro do Rio Grande do Sul, Porto Alegre

05403-010

IPq-HCFMUSP - Instituto de Psiquiatria do Hospital das Clínicas da FMUSP, São Paulo

T2N 4Z6

University of Calgary - Heritage Medical Research Clinic, Calgary

V6T 2B5

UBC Hospital, Vancouver

B3S 1N2

Centricity Research Halifax, Halifax

K1Z 1G3

Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic, Ottawa

K9H 2P4

Kawartha Centre - Redefining Healthy Aging, Peterborough

M3B 2S7

Toronto Memory Program (Neurology Research Inc.), Toronto

M4G 3E8

Centricity Research Toronto LMC, Toronto

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

M6A 2E1

Baycrest Centre for Geriatric Care, Toronto

J8T 8J1

Clinique de la Memoire de l'Outaouais, Gatineau

J4V 2J2

MoCA Research and Innovation Inc, Greenfield Park

H3A 2B4

Montreal Neurological Institute Clinical Research Unit, Montreal

G1J1Z4

CHU de Quebec- Hopital de l Enfant Jesus, Québec

00100

Terveystalo Ruoholahti, Helsinki

00179

Fondazione Santa Lucia IRCCS, Roma

00185

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Roma

474-8511

National Center For Geriatrics And Gerontology, Obu-shi

260-8656

Hakuyokai Kashiwado Hospital, Chiba

263-0043

Inage Neurology and Memory Clinic, Chiba

963-8563

Southern Tohoku Medical Clinic, Koriyama-shi

739-0696

NHO Hiroshima-Nishi Medical Center, Otake-shi

672-8043

Himeji Central Hospital Clinic, Himeji-shi

761-0793

Kagawa University Hospital, Kita-gun

243-8551

Tokushukai Shonan Atsugi Hospital, Atsugi-shi

247-8533

Tokushukai Shonan Kamakura General Hospital, Kamakura-shi

213-8507

Teikyo University Hospital, Mizonokuchi, Kawasaki-shi

607-8113

Rakuwakai Otowa Rehabilitation Hospital, Kyoto

616-8255

NHO Utano National Hospital, Kyoto

710-0813

Katayama Medical Clinic, Kurashiki-shi

596-0042

Tokushukai Kishiwada Tokushukai Hospital, Kishiwada-shi

565-0871

Osaka University Hospital, Suita-shi

344-0036

Midorikai Takesato Hospital, Kasukabe-shi

113-0034

Memory Clinic Ochanomizu, Bunkyō City

187-8551

National Center of Neurology and Psychiatry, Kodaira-shi

990-0834

Tokushukai Yamagata Tokushukai Hospital, Yamagata

85-133

PROMENTE Sp. z o.o., Bydgoszcz

01-684

Centrum Medyczne NeuroProtect, Warsaw

15-756

Podlaskie Centrum Psychogeriatrii, Bialystok

81-855

Centrum Medyczne Senior, Sopot

20-090

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Kliniczny Oddział Neurologii Oddział Udarowy, Lublin

40-650

Nzoz Novo-Med, Katowice

41-100

Neuro-Care Gabriela Klodowska, Siemianowice Śląskie

08028

Fundacio ACE, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

205 02

Skane University Hospital, Malmo

EH8 9YL

The University of Edinburgh, Edinburgh

SE5 8AF

Institute of Psychiatry, Psychology and Neuroscience, London

W1G 9RU

Re:Cognition Health Ltd (London), London

W6 8RF

Charing Cross Hospital, London

MR8 5RB

Park House, Manchester

SO16 6YD

Southampton General Hospital, Southampton

SO30 3JB

Moorgreen Hospital, Southampton

EH12 9DQ

Brain Health Scotland Life Sciences, Edinburgh

BA1 3NG

The RICE Centre, Bath

ML1 4UF

Glasgow Memory Clinic Ltd, Motherwell

BS32 4SY

Re Cognition Health Bristol, Bristol

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY