Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function

NAActive, not recruitingINTERVENTIONAL
Enrollment

1,252

Participants

Timeline

Start Date

April 13, 2021

Primary Completion Date

March 31, 2026

Study Completion Date

October 31, 2027

Conditions
Left Ventricular DysfunctionCoronary Artery Disease
Interventions
DEVICE

Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®

Impella CP / Impella CP with SmartAssist will be used in most patients randomized to the Impella arm. Impella 2.5 may be used in patients with small body size (BMI \<20 kg/m2 or body weight \<60 kg) or if the iliofemoral vasculature is able to accommodate the smaller Impella 2.5 device but not the Impella CP device.

DEVICE

IABP Intra-aortic balloon pump

IABP uses counterpulsation to provide 0.2L/min coronary flow

Trial Locations (102)

3010

Inselspital Bern, Bern

6000

Luzerner Kantonsspital, Lucerne

6900

Istituto Cardiocentro Ticino, Lugano

10016

NYU Langone Health, New York

10029

Icahn School of Medicine at Mt. Sinai, New York

10032

Columbia University Medical Cenrer/NYPH, New York

11030

Northwell University Hospital, Manhasset

11576

St. Francis Hospital and Heart Center, Roslyn

11794

Stony Brook University Hospital (SUNY), Stony Brook

12203

Berlin CBF, Berlin

13353

CVK Berlin, Berlin

14203

University at Buffalo/Kaleida Health, Buffalo

15212

Allegheny General Hospital, Pittsburgh

17403

WellSpan York Hospital, York

17495

Klinikum Karlsburg, Karlsburg

23507

Sentara Norfolk Health System, Norfolk

24014

Carilion Clinic, Roanoke

26506

West Virginia University Hospital, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27607

North Carolina Heart and Vascular Research, Raleigh

27710

Duke University, Durham

28204

Sanger Heart and Vascular Institute, Charlotte

29605

Greenville Hospital System, Greenville

30043

Northside Cardiovascular Institute, Lawrenceville

30322

Emory University Hospital, Atlanta

32209

UF Health Jacksonville, Jacksonville

32605

The Cardiac & Vascular Institute, Gainesville

32610

University of Florida Health - Gainesville, Gainesville

35294

University of Alabama, Birmingham

35392

Universitätsklinikum Gießen, Giessen

37203

Centennial Heart - Nashville, Nashville

37205

Ascension St. Thomas West, Nashville

37232

Vanderbilt University Medical Center, Nashville

37660

Wellmont Cardiology Services, Kingsport

40225

Universitätsklinikum Düsseldorf, Düsseldorf

44106

University Hospitals Cleveland Medical Center, Cleveland

45219

Linder Research Center (The Christ Hospital), Cincinnati

48202

Henry Ford Hospital, Detroit

48236

Henry Ford St. John Hospital, Detroit

49435

Corewell Health, Grand Rapids

50733

St. Vinzenz-Hospital GMBH KÖLN, Cologne

52074

University Hospital Aachen, Aachen

53215

Aurora St. Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

54292

Krankenhaus der Barmherzigen Brüder, Trier

55433

Metropolitan Heart and Vascular Institute / Metropolitan Cardiology Consultants, Coon Rapids

56303

CentraCare (St. Cloud Hospital), Saint Cloud

60201

NorthShore University Health System, Evanston

60208

Northwestern University, Evanston

60453

Advocate Christ Medical Center, Oak Lawn

60612

Rush University Medical Center, Chicago

63044

SSM Health DePaul Hospital, Bridgeton

64111

St. Luke's Hospital, Kansas City

67226

Cardiovascular Research Institute of Kansas, Wichita

70121

Ochsner Foundation Hospital, New Orleans

72205

Arkansas Cardiology, Little Rock

73104

University of Oklahoma Medical Center, Oklahoma City

75093

Baylor Scott & White Heart - Plano, Plano

75231

Presbyterian Hospital Dallas / Texas Health Physicians Group, Dallas

76104

Medical City Fort Worth, Fort Worth

77004

HCA Houston Healthcare, Houston

77030

Houston Methodist Hospital, Houston

Memorial Hermann Texas Medical Center (UT Health), Houston

Texas Heart Institute at Baylor St. Luke's Hospital, Houston

77339

Texas Cardiology Associates of Houston, Kingwood

78229

Methodist Hospital - San Antonio, San Antonio

79189

Universitätsklinikum Freiburg, Universitäts-Herzzentrum, Bad Krozingen

80228

Colorado Heart and Vascular, Lakewood

81675

Klinikum rechts der Isar der TUM, Munich

85016

St. Joseph's Medical Center - Phoenix, Phoenix

85741

Northwest Medical Center Tucson, Tucson

87102

Lovelace/New Mexico Heart Institute, Albuquerque

88048

Klinikum Friedrichshafen GmbH, Friedrichshafen

90036

Keck School of Medicine of USC, Los Angeles

91054

Universitätsklinikum Erlangen, Erlangen

91206

Adventist Health Glendale, Glendale

92093

UCSD Medical Center, San Diego

92354

Loma Linda University Health, San Bernardino

92868

St. Joseph Hospital - Orange, Orange

97080

Uniklinik Würzburg, Würzburg

97225

Providence St. Vincent Medical Center, Portland

98195

University Of Washington Medical Center, Seattle

06106

Hartford Hospital, Hartford

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

03102

Catholic Medical Center, Manchester

07631

Englewood Hospital, Englewood

07601

Hackensack University Medical Center, Hackensack

07960

Morristown Medical Center, Morristown

07735

Jersey Shore University Medical Center, Neptune City

07450

The Valley Hospital - Ridgewood, Ridgewood

10467-2401

Montefiore Medical Center - Moses, The Bronx

Unknown

Toronto General Hospital, Toronto

University Hopsital Frankfurt, Frankfurt

Ospedale di San Donato, San Donato Milanese

Royal Brompton Hospital, London

H4A 3J1

Royal Victoria Hospital, Montreal

09116

Klinikum Chemnitz gGmbH, Chemnitz

01307

Herzzentrum Dresden GmbH, Dresden

00168

Policlinico Universitario Agostino Gemelli, Rome

5623 EJ

Catharina Ziekenhuis Eindhoven, Eindhoven

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Abiomed Inc.

INDUSTRY