Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients

NAActive, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

May 28, 2021

Primary Completion Date

October 31, 2025

Study Completion Date

December 31, 2026

Conditions
Unresectable Hepatocellular CarcinomaBCLC Stage A Hepatocellular CarcinomaBCLC Stage B Hepatocellular CarcinomaBCLC Stage C Hepatocellular Carcinoma
Interventions
DEVICE

Resin microspheres containing yttrium-90 (Y-90)

Biocompatible resin microspheres are an injectable permanent implant and preferentially placed into the distal microvascular supply of tumors to provide direct irradiation of tissue and destruction of the microvascular bed. Spheres contain yttrium-90 (Y-90) and are a size between 20 and 60 microns in diameter.

Trial Locations (22)

10032

Columbia University CUIMC/NYPH, New York

15212

Allegheny-Singer Research Institute, Pittsburgh

19104

Hospital of the University Pennsylvania, Philadelphia

27157

Wake Forest Baptist Health, Winston-Salem

27599

University of North Carolina - Chapel Hill Medical Center, Chapel Hill

30308

Emory University Hospital Midtown, Atlanta

33176

Miami Cardiac and Vascular Institute at Baptist Hospital, Miami

34239

Sarasota Memorial Health Care System, Sarasota

44195

The Cleveland Clinic Foundation, Cleveland

45267

University of Cincinnati Cancer Center CTO, Cincinnati

66160

University of Kansas Medical Center, Kansas City

75203

Clinical Research Institute and Methodist Hospital, Dallas

77030

University of Texas Health Science Center at Houston, Houston

UT MD Anderson Cancer Center, Houston

90095

University of California Los Angeles - Ronald Reagan Medical Center, Los Angeles

92868

Providence St. Joseph Hospital, Orange

University of California Irvine, Orange

99208

Inland Imaging, Spokane

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

02903

Rhode Island Hospital, Providence

05401

The University of Vermont Medical Center, Burlington

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Bright Research Partners

INDUSTRY

lead

Sirtex Medical

INDUSTRY