Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

727

Participants

Timeline

Start Date

February 25, 2020

Primary Completion Date

February 28, 2026

Study Completion Date

August 31, 2026

Conditions
Select Advanced Solid Tumors
Interventions
DRUG

Brenetafusp

Brenetafusp IV infusions

DRUG

Brenetafusp and pembrolizumab

Brenetafusp and pembrolizumab IV infusions

DRUG

Brenetafusp and chemotherapy

Brenetafusp and chemotherapy IV infusions

DRUG

Brenetafusp and monoclonal antibodies and chemotherapy

Brenetafusp and a monoclonal antibody therapy and chemotherapy

DRUG

Brenetafusp and tebentafusp

Brenetafusp and tebentafusp IV infusions

DRUG

Brenetafusp and bevacizumab

Brenetafusp and bevacizumab IV infusions

DRUG

Brenetafusp and kinase inhibitors

Brenetafusp and oral kinase inhibitors

Trial Locations (76)

1066

RECRUITING

Netherlands Cancer Institute, Amsterdam

1070

ACTIVE_NOT_RECRUITING

Institut Jules Bordet, Brussels

1090

RECRUITING

Universitair Ziekenhuis Brussel, Jette

2031

COMPLETED

Scientia Clinical Research, Randwick

2065

RECRUITING

Melanoma Institute Australia (MIA) - The Poche Centre, Wollstonecraft

2333

RECRUITING

Leiden UMC, Leiden

2650

RECRUITING

UZA, Edegem

3000

ACTIVE_NOT_RECRUITING

UZ Leuven, Leuven

3004

ACTIVE_NOT_RECRUITING

The Alfred Hospital, Melbourne

4000

RECRUITING

CHU de Liege, Liège

4031

RECRUITING

University Hospital, Basel Switzerland, Basel

5020

COMPLETED

LKH - Universitätsklinikum der PMU Salzburg, Salzburg

6009

RECRUITING

Linear Clinical Research, Nedlands

8058

COMPLETED

University Hospital of Zurich, Zurich

9000

RECRUITING

Universitair Ziekenhuis Gent, Ghent

9713

ACTIVE_NOT_RECRUITING

UMC Groningen Comprehensive Cancer Center, Groningen

10032

ACTIVE_NOT_RECRUITING

Columbia University Medical Center, New York

10065

RECRUITING

Memorial Sloan Kettering, New York

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

19104

RECRUITING

Abramson Cancer Center of the University of Pennsylvania, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

20057

ACTIVE_NOT_RECRUITING

Georgetown University Medical Center, Washington D.C.

28022

RECRUITING

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Madrid, Madrid

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

31008

RECRUITING

Universidad de Navarra - Clinica Universidad de Navarra (CUN) - Pamplona, Pamplona

33612

RECRUITING

Houston Lee Moffitt Cancer Center & Research Institute, Tampa

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

52242

RECRUITING

University of Iowa, Iowa City

53705

RECRUITING

University of Wisconsin, Madison

60637

RECRUITING

The University of Chicago Medical Center, Chicago

69100

RECRUITING

Universite Claude Bernard Lyon Est, Lyon

69120

COMPLETED

Universitaetsklinikum Heidelberg, Heidelberg

73104

RECRUITING

University of Oklahoma Peggy and Charles Stephenson Cancer Center, Oklahoma City

75010

RECRUITING

Hopital Saint-Louis - Centre d'Onco-Dermatologie, Paris

77030

ACTIVE_NOT_RECRUITING

MD Anderson Cancer Center, Houston

80045

RECRUITING

University of Colorado, Aurora

80131

RECRUITING

"Istituto Nazionale Tumori IRCCS Fondazione G. Pascale", Napoli

84112

RECRUITING

University of Utah - Huntsman Cancer Institute, Salt Lake City

90025

RECRUITING

Angeles Clinic and Research Institute, Los Angeles

92093

RECRUITING

University of California - San Diego, La Jolla

92697

COMPLETED

Prisma Health, Greenville

ACTIVE_NOT_RECRUITING

New Zealand Clinical Research-Auckland, Auckland

94805

RECRUITING

Gustave Roussy (Institut de Cancerologie Gustave-Roussy), Villejuif

95817

RECRUITING

University of California Davis Comprehensive Center, Sacramento

98109

RECRUITING

University of Washington - Fred Hutchinson Cancer Center, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

07601

COMPLETED

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

91350-200

RECRUITING

Hospital Nossa Senhora da Conceicao, Porto Alegre

Unknown

ACTIVE_NOT_RECRUITING

D'Or Institute for Research and Education, Rio de Janeiro

RECRUITING

National Cancer Institute, Rio de Janeiro

ACTIVE_NOT_RECRUITING

Hospital Israelita Albert Einstein, São Paulo

RECRUITING

Institut Bergonie - Nouvelle-Aquitaine, Bordeaux

RECRUITING

Institut Curie, Paris

COMPLETED

St Vincents University Hospital, Dublin

RECRUITING

Centre Hospitalier Universitaire Vaudois Lausanne, Lausanne

RECRUITING

Guy's and St Thomas' NHS Foundation Trust, London

RECRUITING

The Christie NHS Foundation Trust, Manchester

M5G 2C4

RECRUITING

Princess Margaret Cancer Centre, Toronto

H2X 0A9

COMPLETED

CHUM Centre de Recherche, Montreal

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Medicina Interna e Scienze Mediche, Rome

ACTIVE_NOT_RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Patologia Ostetrica e Ginecologica, Seriate

60-185

RECRUITING

Centrum Medyczne Pratia Poznan - Skorzewo, Skórzewo

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Yonsei University College of Medicine, Seoul

05505

RECRUITING

University of Ulsan College of Medicine, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

08023

RECRUITING

NEXT Barcelona, Barcelona

08035

RECRUITING

Hospital Universitario Vall dHebron, Barcelona

08908

RECRUITING

Hospital Duran i Reynals, Barcelona

W1G6AD

RECRUITING

Sarah Cannon Research Institute UK, London

OX3 7LI

RECRUITING

University of Oxford, Oxford

G12 0YN

RECRUITING

The Beatson West of Scotland Cancer Centre, Glasgow

L69 3BX

RECRUITING

University of Liverpool, Liverpool

W1T7HA

RECRUITING

University College Hospital London, London

SM25PT

RECRUITING

Royal Marsden Hospital, Surrey Quays

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Immunocore Ltd

INDUSTRY

NCT04262466 - Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors | Biotech Hunter | Biotech Hunter