A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,696

Participants

Timeline

Start Date

March 2, 2020

Primary Completion Date

July 22, 2024

Study Completion Date

July 22, 2024

Conditions
Alzheimer's Disease
Interventions
DRUG

Aducanumab

Administered as specified in the treatment arm.

Trial Locations (297)

179

Fondazione Santa Lucia IRCCS, Roma

333

Chang Gung Memorial Hospital, Linkou, Taoyuan

704

National Cheng Kung University Hospital, Tainan City

833

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1011

Centre Hospitalier Universitaire Vaudois, Lausanne

1090

AKH - Medizinische Universität Wien, Vienna

Universitair Ziekenhuis Brussel, Brussels

1205

Hôpitaux Universitaires de Geneve- HUG, Geneva

2010

St Vincent's Hospital Sydney, Darlinghurst

2100

Danish Dementia Research Centre, Copenhagen

2113

KaRa Institute of Neurological Diseases, Macquarie Park

2250

Central Coast Neurosciences Research (Erina), Erina

2501

Spitalzentrum Biel, Biel/Bienne

2930

AZ Klina, Brasschaat

3000

UZ Leuven, Leuven

3050

Royal Melbourne Hospital, Parkville

3081

Austin Health, Heidelberg West

3128

Box Hill Hospital, Box Hill

4032

The Prince Charles Hospital, Chermside

5020

Christian-Doppler-Klinik - Universitätsklinikum Salzburg, Salzburg

6009

Australian Alzheimer's Research Foundation, Nedlands

6900

Ospedale Regionale di Lugano, Lugano

7100

CCBR - Vejle - DK, Vejle

8000

AZ Sint-Jan, Bruges

8036

LKH - Universitaetsklinikum Graz, Graz

8500

AZ Groeninge, Kortrijk

8800

AZ Delta, Roeselare

8952

Institut fur Regenerative Medizin-IREM Universitat Zurich, Campus Schlieren, Schlieren

9000

Universitair Ziekenhuis Gent, Ghent

CCBR - Ålborg - DK, Aalborg

10016

New York University Medical Center PRIME, New York

10021

Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC), New York

10029

Mount Sinai School of Medicine, New York

10629

Emovis GmbH, Berlin

11217

Taipei Veterans General Hospital, Taipei

12099

Neurologie im Tempelhofer Hafen, Berlin

12110

Empire Neurology, PC, Latham

12208

Albany Medical College, Albany

13125

Charite Universitaetsmedizin Berlin - Campus Berlin Buch, Berlin

13385

Hôpital de la Timone, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

13875

Ospedale degli Infermi, Ponderano

14011

Hospital Universitario Reina Sofia, Córdoba

14620

University of Rochester, Rochester

15261

University of Pittsburgh, Pittsburgh

16132

Azienda Ospedaliero Universitaria San Martino, Genova

18104

Lehigh Center for Clinical Research, LLC, Allentown

18705

Northeastern Pennsylvania Memory and Alzheimer's Center, Wilkes-Barre

19046

The Clinical Trial Center, LLC, Jenkintown

19104

Penn Memory Center, Philadelphia

20007

Georgetown University Clinical Research Unit (CRU), Washington D.C.

20009

Policlinica Gipuzkoa, Donostia / San Sebastian

20052

ASST di Monza, Monza

20132

Ospedale San Raffaele, Milan

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan

20520

CRST, Clinical Research Services Turku, Turku

22332

Inha University Hospital, Incheon

23294

National Clinical Research Inc.-Richmond, Richmond

25123

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia

25198

Hospital Universitari de Santa Maria, Lleida

27103

Gastroenterology Associates of the Piedmont, Winston-Salem

28006

Complejo Hospitalario Ruber Juan Bravo, Madrid

28270

AMC Research, LLC, Charlotte

29401

Roper St. Francis Healthcare, Charleston

29425

Medical University of South Carolina (MUSC), Charleston

30033

NeuroStudies.net, LLC, Decatur

30159

Klinische Forschung Hannover-Mitte GmbH, Hanover

30329

Emory University Cognitive Neurology Clinic & ADRC, Atlanta

31008

Clinica Universidad de Navarra, Pamplona

31059

Hopital Purpan, Toulouse

Hôpital La Grave, Toulouse

31909

Medical Research Health and Education Foundation, Inc, Columbus

32162

Accelerated Enrollment Solutions (AES), Orlando

32216

Jacksonville Center for Clinical Research, Jacksonville

32801

Clinical Neuroscience Solutions, Inc., Orlando

32806

Accelerated Enrollment Solutions (AES), Orlando

33024

Infinity Clinical Research, LLC, Hollywood

33064

Quantum Laboratories Inc., Pompano Beach

33076

Groupe Hospitalier Pellegrin - Hôpital Pellegrin, Bordeaux

33136

University of Miami, Miami

33180

Miami Jewish Health System, Inc, Miami

33331

Cleveland Clinic Florida - Weston, Weston

33407

Premiere Research Institute, West Palm Beach

33410

Palm Beach Neurological Center, Palm Beach Gardens

Senior Adult Specialty Research, Austin

33462

JEM Research, Atlantis

Mayo Clinic in Florida, Jacksonville

33609

Axiom Clinical Research of Florida, Tampa

33613

Stedman Clinical Trials, LLC, Tampa

33616

USF Health Byrd Institute, Tampa

33634

Meridien Research, Tampa

33647

Neurozentrum Bielefeld, Bielefeld

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34121

Neurologische Gemeinschaftspraxis Kassel, Kassel

34205

Bradenton Research Center, Inc, Bradenton

34295

Hopital Gui de Chauliac, Montpellier

34470

Renstar Medical Research, Ocala

35033

CHU Rennes - Pontchaillou, Rennes

35233

University of Alabama at Birmingham, Birmingham

38018

Neurology Clinic, PC, Cordova

39401

Hattiesburg Clinic, PA, Hattiesburg

40225

Universitaetsklinikum Duesseldorf AoeR, Düsseldorf

40503

Baptist Health Lexington, Lexington

41009

Hospital Victoria Eugenia, Seville

43210

Ohio State University Wexner Medical Center, Columbus

44093

CHU Nantes - Hopital Nord Laënnec, Nantes

44195

Cleveland Clinic Foundation, Cleveland

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University School of Medicine, Indianapolis

46256

Josephson, Wallack, Munshower Neurology, P.C., Indianapolis

46804

Fort Wayne Neurological Center, Fort Wayne

48993

CAE Oroitu, Getxo

50004

Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua

50937

Universitaetsklinikum Koeln, Cologne

51092

CHU Reims - Hôpital Maison Blanche, Reims

52074

Universitaetsklinikum Aachen AOeR, Aachen

53100

A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena

53226

Medical College of Wisconsin, Inc., Milwaukee

53659

NZOZ Wroclawskie Centrum Alzheimerowskie, Wroclaw

55902

Mayo Clinic, Rochester

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

57076

Zentrum f. Neurologisch- Psychiatrische Studien und Begutachtung, Siegen

59037

CHU Lille - Hopital Roger Salengro, Lille

60007

Alexian Brothers Medical Center - Neuroscience Research Institute, Elk Grove Village

60068

Advocate Lutheran General Hospital, Park Ridge

63108

Washington University, St Louis

64711

Neuro Centrum Science GmbH, Geschaftführende Gesellschafterin Barbara Unsorg und Prüfarzt Dr. med. G, Erbach im Odenwald

66205

University of Kansas Medical Center Research Institute, Inc., Fairway

67098

CHU Strasbourg - Hôpital Hautepierre, Strasbourg

67214

Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc., Wichita

68165

ISPG - Institut fuer Studien zur Psychischen Gesundheit, Mannheim

69100

Hôpital des Chapennes, Villeurbanne

69677

CHU de Lyon - Hopital Neurologique Pierre Wertheimer, Bron

70182

mind mvz GmbH, Stuttgart

70210

Itä-Suomen yliopisto, Aivotutkimusyksikkö, Kuopio

71034

Studienzentrum fur Neurologie und Psychiatrie, Böblingen

73039

Azienda Ospedaliera Card. G. Panico, Tricase

73112

Lynn Health Science Institute, Oklahoma City

75010

Hôpital Lariboisière, Paris

75013

Groupe Hospitalier Pitie-Salpetriere, Paris

Hôpital Broca, Paris

75185

Akademiska Sjukhuset, Uppsala

77030

Baylor College of Medicine, Houston

77074

Clinical Trial Network, Houston

80045

University of Colorado Denver, Aurora

80112

IMMUNOe International Research Centers, Centennial

80138

AOU dell'Università degli studi della Campania Luigi Vanvitelli, Napoli

81377

Institut fuer Schlaganfall- und Demenzforschung (ISD), München

81675

Klinikum rechts der Isar der TU Muenchen, Munich

82008

Neuropraxis Muenchen Sued, Unterhaching

84108

University of Utah Health Sciences Center, Salt Lake City

84131

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona, Salerno

85006

Banner Alzheimer's Institute, Phoenix

85013

Dignity Health, Phoenix

85351

Banner Sun Health Research Institute, Sun City

85718

Center for Neurosciences, Tucson

89073

Neuropoint Studienzentrum, Ulm

89081

Universitaetsklinikum Ulm, Ulm

89106

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas

89113

Las Vegas Medical Research, Las Vegas

89312

Bezirkskrankenhaus Guenzburg, Günzburg

90015

Fondazione Istituto G.Giglio di Cefalù, Cefalù

90033

USC Keck School of Medicine, Los Angeles

90095

Mary S. Easton Center for Alzheimer's Disease Research, UCLA, Los Angeles

91403

California Neuroscience Research Medical Group Inc., Sherman Oaks

92037

University of California San Diego Medical Center, La Jolla

92103

Pacific Research Network, Inc, San Diego

92374

Anderson Clinical Research, Redlands

92607

UCI MIND, Irvine

92653

Senior Clinical Trials, Inc., Laguna Hills

92705

Syrentis Clinical Research, Santa Ana

92835

Neurology Center of North Orange County, Fullerton

93030

Pacific Neuroscience Medical Group, Oxnard

94143

UCSF - Memory and Aging Center, San Francisco

94304

Stanford Hospital and Clinics, Palo Alto

95445

Klinikum Bayreuth GmbH- Hohe Warte, Bayreuth

99202

Kingfisher Cooperative, LLC, Spokane

334405

Brain Matters Research, Delray Beach

06824

Yale University, Fairfield

06510

Invicro, New Haven

Yale University School Of Medicine, New Haven

06851

Research Center for Clinical Studies, Inc., Norwalk

02474

McLean Hospital, Belmont

02215

Beth Israel Deaconess Medical Center, Boston

Brigham and Women's Hospital Department of Neurology, Boston

01844

ActivMed Practices & Research, Inc., Methuen

02459

Boston Center for Memory, Newton

02360

Donald S. Marks, M.D., P.C., Plymouth

03801

ActivMed Practices & Research, Inc., Portsmouth

08755

Advanced Memory Research Inst. of NJ, PC, Toms River

27607-6010

Raleigh Neurology Associates, Raleigh

27157-1207

Wake Forest Baptist Health, Winston-Salem

02914

Rhode Island Mood & Memory Research Institute, East Providence

02903

Rhode Island Hospital, Providence

02906

Butler Hospital, Providence

75390-9129

UT Southwestern Medical Center, Dallas

05201

The Memory Clinic, Bennington

98104-2499

University of Washington Medical Centre, Seattle

T2N4Z6

University of Calgary - Heritage Medical Research Clinic, Calgary

V2C 5T1

The Medical Arts Health Research Group, Kamloops

V2A 5L5

The Medical Arts Health Research Group, Penticton

V6T 1Z3

UBC Hospital, Vancouver

V7T 1C5

Medical Arts Health Research Group, West Vancouver

B3S 1M7

True North Clinical Research - Halifax Inc., Halifax

MB3 2S7

True North Clinical Research, Kentville

N6C OA7

St. Joseph's HC- Parkwood Institute, London

K1N 5C8

Bruyere Continuing Care, Ottawa

K9H 2P4

Kawartha Centre - Redefining Healthy Aging, Peterborough

M3B 2S7

Toronto Memory Program (Neurology Research Inc.), Toronto

M4N 3M5

Toronto Sunnybrook Hospital, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

J8T 8J1

Clinique de la Memoire de l'Outaouais, Gatineau

J4V 2J2

Institut et Clinique MoCA, Greenfield Park

H3A 2B4

Montreal Neurological Institute Clinical Research Unit, Montreal

G1J 1Z4

CHU de Quebec - Hôpital de l' Enfant Jésus, Québec

00180

Terveystalo Ruoholahti, Helsinki

04600

Klinikum Altenburger Land GmbH, Altenburg

06156

Azienda Ospedaliera e Universitaria di Perugia, Perugia

00161

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Roma

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

474-8511

Research Site, Obu-shi

260-8656

Research Site, Chiba

263-0043

Research Site, Chiba

270-1694

Research Site, Inzai-shi

791-0295

Research Site, Toon-shi

814-0180

Research Site, Fukuoka

830-0011

Research Site, Kurume-shi

965-8585

Research Site, Aizu-Wakamatsu

739-0696

Research Site, Otake-shi

070-8644

Research Site, Asahikawa-shi

064-8570

Research Site, Sapporo

660-8511

Research Site, Amagasaki-shi

670-0981

Research Site, Himeji-shi

672-8043

Research Site, Himeji-shi

650-0047

Research Site, Kobe

761-0793

Research Site, Kita-gun

247-8533

Research Site, Kamakura-shi

Research Site, Kurashiki-shi

607-8113

Research Site, Kyoto

616-8255

Research Site, Kyoto

514-8507

Research Site, Tsu

851-2103

Research Site, Togitsu

940-2081

Research Site, Nagaoka-shi

879-5593

Research Site, Yufu-shi

703-8265

Research Site, Okayama

701-0304

Research Site, Tsukuba

545-8586

Research Site, Osaka

565-0871

Research Site, Suita-shi

350-0495

Research Site, Iruma-gun

344-0036

Research Site, Kasukabe-shi

424-8636

Research Site, Shizuka-shi

420-8688

Research Site, Shizuoka

113-0034

Research Site, Bunkyō City

204-8585

Research Site, Kiyose-shi

187-8551

Research Site, Kodaira-shi

990-0834

Research Site, Yamagata

1081 GN

Brain Research Center, Amsterdam

4818 CK

Amphia Ziekenhuis, Molengracht, Breda

3015 AA

Erasmus Medisch Centrum, Rotterdam

15-756

Podlaskie Centrum Psychogeriatrii, Bialystok

85-023

PALLMED Sp. z o.o., Bydgoszcz

80-952

Klinika Psychiatrii Doroslych UCK, Gdansk

40-650

Novo-Med Zielinski i wspolnicy Sp. j., Katowice

92-216

SPZOZ Centralny Szpital Kliniczny UM w Lodzi, Lodz

20-954

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin

61-853

"NZOZ NEURO-KARD, Ilkowski i Partnerzy Sp. Partn. Lek.", Poznan

41-100

Neuro-Care Gabriela Klodowska, Siemianowice Śląskie

81-855

Centrum Medyczne Senior, Sopot

70-111

Osrodek Badan Klinicznych EUROMEDIS, Szczecin

01-684

Centrum Medyczne NeuroProtect, Warsaw

4710-243

Hospital de Braga, Braga

3040-278

Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra, Coimbra

2674-514

Hospital Beatriz Ângelo, Loures

2560-280

CNS-Campus Neurologico Senior, Torres Vedras

405-760

Gachon University Gil Medical Center, Incheon

05030

Konkuk University Medical Center, Seoul

05505

Asan Medical Center, Seoul

135-710

Samsung Medical Center, Seoul

03203

Hospital General Universitario de Elche, Elche

08003

Hospital del Mar, Barcelona

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08028

Fundacio ACE, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

205 02

Skånes Universitetssjukhus, Malmo

Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus, Mölndal

141 86

Karolinska Universitetssjukhuset, Huddinge, Stockholm

W1G 9JF

Re:Cognition Health Ltd (London), London

W6 8RF

Charing Cross Hospital, London

WC1N 3BG

The National Hospital for Neurology and Neurosurgery Centre, London

M13 9WL

Manchester Royal Infirmary, Manchester

EH10 5HF

The University of Edinburgh, Edinburgh

BA1 3NG

The RICE Centre, Bath

G21 3UW

Queen Elizabeth University Hospital Campus, Glasgow

ML1 4UF

Glasgow Memory Clinic Ltd, Motherwell

DD1 9SY

Ninewells Hospital, Dundee

NE4 5PL

Newcastle University, Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY