186
Participants
Start Date
October 17, 2019
Primary Completion Date
October 31, 2026
Study Completion Date
June 30, 2028
Abemaciclib
Given PO
PI3K Inhibitor paxalisib
Given PO
Entrectinib
Given PO
Adagrasib
Given PO
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Manhattan Eye Ear and Throat Hospital, New York
NYP/Weill Cornell Medical Center, New York
Lenox Hill Hospital, New York
Northwell Health/Center for Advanced Medicine, Lake Success
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
Glens Falls Hospital, Glens Falls
State University of New York Upstate Medical University, Syracuse
Upstate Cancer Center at Verona, Verona
University of Rochester, Rochester
Arnot Ogden Medical Center/Falck Cancer Center, Elmira
UPMC-Magee Womens Hospital, Pittsburgh
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Saint Luke's Hospital-Anderson Campus, Easton
Lehigh Valley Hospital-Cedar Crest, Allentown
Saint Luke's Cancer Center - Allentown, Allentown
Lehigh Valley Hospital-Hazleton, Hazleton
Pocono Medical Center, East Stroudsburg
Saint Luke's Hospital-Quakertown Campus, Quakertown
Pennsylvania Hospital, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
Inova Schar Cancer Institute, Fairfax
Inova Fair Oaks Hospital, Fairfax
Bon Secours Saint Francis Medical Center, Midlothian
Bon Secours Cancer Institute at Reynolds Crossing, Richmond
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Atrium Health Cabarrus/LCI-Concord, Concord
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Atrium Health Pineville/LCI-Pineville, Charlotte
ECU Health Oncology Kenansville, Kenansville
ECU Health Oncology Kinston, Kinston
ECU Health Oncology Richlands, Richlands
Margaret R Pardee Memorial Hospital, Hendersonville
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
Holy Cross Hospital, Fort Lauderdale
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
Boca Raton Regional Hospital, Boca Raton
University of Mississippi Medical Center, Jackson
Flaget Memorial Hospital, Bardstown
Jewish Hospital Medical Center South, Shepherdsville
Jewish Hospital, Louisville
Saints Mary and Elizabeth Hospital, Louisville
UofL Health Medical Center Northeast, Louisville
Saint Joseph Radiation Oncology Resource Center, Lexington
Saint Joseph Hospital East, Lexington
University of Kentucky/Markey Cancer Center, Lexington
Commonwealth Cancer Center-Corbin, Corbin
Saint Joseph London, London
Delaware Health Center-Grady Cancer Center, Delaware
Grady Memorial Hospital, Delaware
Columbus Oncology and Hematology Associates, Dublin
Dublin Methodist Hospital, Dublin
Ohio State University Comprehensive Cancer Center, Columbus
Columbus Oncology and Hematology Associates Inc, Columbus
Riverside Methodist Hospital, Columbus
Grant Medical Center, Columbus
Doctors Hospital, Columbus
OhioHealth Marion General Hospital, Marion
Mercy Health - Perrysburg Hospital, Perrysburg
Mercy Health - Saint Anne Hospital, Toledo
Toledo Clinic Cancer Centers-Toledo, Toledo
Geauga Hospital, Chardon
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
UH Seidman Cancer Center at Saint John Medical Center, Westlake
University Hospitals Portage Medical Center, Ravenna
University Hospitals Sharon Health Center, Wadsworth
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky
OhioHealth Mansfield Hospital, Mansfield
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Good Samaritan Hospital - Cincinnati, Cincinnati
Bethesda North Hospital, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
TriHealth Cancer Institute-Anderson, Cincinnati
Miami Valley Cancer Care and Infusion, Greenville
Upper Valley Medical Center, Troy
Miami Valley Hospital, Dayton
Premier Blood and Cancer Center, Dayton
Miami Valley Hospital North, Dayton
Miami Valley Hospital South, Centerville
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Henry Ford Saint John Hospital - Macomb Medical, Macomb
Henry Ford Warren Hospital - Breast Macomb, Macomb
Henry Ford River District Hospital, East China Township
Henry Ford Health Providence Southfield Hospital, Southfield
Advanced Breast Care Center PLLC, Warren
Henry Ford Health Warren Hospital, Warren
Henry Ford Madison Heights Hospital - Breast, Warren
Henry Ford Warren Hospital - GLCMS, Warren
Macomb Hematology Oncology PC, Warren
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Huron Gastroenterology PC, Ypsilanti
University of Michigan Comprehensive Cancer Center, Ann Arbor
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Trinity Health Medical Center - Brighton, Brighton
University of Michigan - Brighton Center for Specialty Care, Brighton
Chelsea Hospital, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Henry Ford Medical Center-Fairlane, Dearborn
Hope Cancer Clinic, Livonia
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Toledo Clinic Cancer Centers-Monroe, Monroe
Henry Ford Cancer Institute-Downriver, Brownstown
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health Medical Center - Canton, Canton
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
Henry Ford Hospital, Detroit
Henry Ford Health Saint John Hospital, Detroit
Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods
Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods
Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods
Henry Ford Rochester Hospital, Rochester Hills
Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights
Henry Ford Macomb Health Center - Shelby Township, Shelby
Henry Ford West Bloomfield Hospital, West Bloomfield
Hope Cancer Center, Pontiac
Michigan Healthcare Professionals Pontiac, Pontiac
Newland Medical Associates-Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Hematology Oncology Consultants-Clarkston, Clarkston
Newland Medical Associates-Clarkston, Clarkston
Henry Ford Health Providence Novi Hospital, Novi
Henry Ford Medical Center-Columbus, Novi
Saint Mary's Oncology/Hematology Associates of Marlette, Marlette
Cancer Hematology Centers - Flint, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
MyMichigan Medical Center Saginaw, Saginaw
Oncology Hematology Associates of Saginaw Valley PC, Saginaw
Saint Mary's Oncology/Hematology Associates of West Branch, West Branch
Caro Cancer Center, Caro
MyMichigan Medical Center Tawas, Tawas City
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Allegiance Health, Jackson
Hickman Cancer Center, Adrian
Trinity Health Muskegon Hospital, Muskegon
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
University of Michigan Health - West, Wyoming
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Broadlawns Medical Center, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Iowa Lutheran Hospital, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
McFarland Clinic - Trinity Cancer Center, Fort Dodge
UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge
Greater Regional Medical Center, Creston
Saint Anthony Regional Hospital, Carroll
Alegent Health Mercy Hospital, Council Bluffs
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Saint Luke's South Shore, Cudahy
Aurora Cancer Care-Kenosha South, Kenosha
ProHealth D N Greenwald Center, Mukwonago
UW Cancer Center at ProHealth Care, Waukesha
Aurora Cancer Care-Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
Cancer Center of Western Wisconsin, New Richmond
Aurora Bay Area Medical Group-Marinette, Marinette
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Cambridge Medical Center, Cambridge
Lakeview Hospital, Stillwater
Fairview Lakes Medical Center, Wyoming
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Minnesota Oncology - Burnsville, Burnsville
Monticello Cancer Center, Monticello
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Fairview Northland Medical Center, Princeton
Saint Francis Regional Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
Health Partners Inc, Minneapolis
Mayo Clinic in Rochester, Rochester
New Ulm Medical Center, New Ulm
Rice Memorial Hospital, Willmar
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Billings Clinic Cancer Center, Billings
Benefis Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Community Hospital of Anaconda, Anaconda
Bozeman Health Deaconess Hospital, Bozeman
Saint Patrick Hospital - Community Hospital, Missoula
Community Medical Center, Missoula
Logan Health Medical Center, Kalispell
Advocate Good Shepherd Hospital, Barrington
AMG Crystal Lake - Oncology, Crystal Lake
Northwestern Medicine Lake Forest Hospital, Lake Forest
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Advocate Sherman Hospital, Elgin
Northwestern Medicine Cancer Center Delnor, Geneva
Advocate South Suburban Hospital, Hazel Crest
Rush-Copley Medical Center, Aurora
Advocate Good Samaritan Hospital, Downers Grove
Northwestern Medicine Cancer Center Warrenville, Warrenville
Rush-Copley Healthcare Center, Yorkville
Northwestern University, Chicago
Rush University Medical Center, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Advocate Illinois Masonic Medical Center, Chicago
Carle Cancer Center, Urbana
The Carle Foundation Hospital, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
OSF Saint Anthony's Health Center, Alton
Carle Physician Group-Effingham, Effingham
SSM Health Good Samaritan, Mount Vernon
Mercy Oncology and Hematology - Clayton-Clarkson, Ballwin
Mercy Hospital Washington, Washington
Mercy Infusion Center - Chippewa, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital South, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City
University of Kansas Cancer Center - North, Kansas City
Heartland Regional Medical Center, Saint Joseph
Freeman Health System, Joplin
Mercy Hospital Joplin, Joplin
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Central Care Cancer Center - Bolivar, Bolivar
Cox Cancer Center Branson, Branson
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Lawrence Memorial Hospital, Lawrence
The University of Kansas Cancer Center - Olathe, Olathe
University of Kansas Cancer Center, Kansas City
University of Kansas Hospital-Westwood Cancer Center, Westwood
University of Kansas Cancer Center-Overland Park, Overland Park
University of Kansas Hospital-Indian Creek Campus, Overland Park
Central Care Cancer Center - Great Bend, Great Bend
HaysMed, Hays
Central Care Cancer Center - Garden City, Garden City
Midlands Community Hospital, Papillion
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
Saint Elizabeth Regional Medical Center, Lincoln
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
CHI Health Good Samaritan, Kearney
Louisiana State University Health Science Center, New Orleans
Tulane University School of Medicine, New Orleans
University Medical Center New Orleans, New Orleans
Ochsner LSU Health Saint Mary's Medical Center, Shreveport
LSU Health Sciences Center at Shreveport, Shreveport
Ochsner LSU Health Monroe Medical Center, Monroe
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs
Mercy Hospital Fort Smith, Fort Smith
University of Oklahoma Health Sciences Center, Oklahoma City
Mercy Hospital Oklahoma City, Oklahoma City
Parkland Memorial Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth
Memorial Hermann Texas Medical Center, Houston
Memorial Hermann Northeast Hospital, Humble
Memorial Hermann The Woodlands Hospital, The Woodlands
Saint Joseph Regional Cancer Center, Bryan
AdventHealth Littleton, Littleton
AdventHealth Parker, Parker
AdventHealth Porter, Denver
Saint Anthony Hospital, Lakewood
Longmont United Hospital, Longmont
Rocky Mountain Cancer Centers-Longmont, Longmont
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
CommonSpirit Cancer Center Mercy, Durango
Mercy Medical Center, Durango
Billings Clinic-Cody, Cody
Welch Cancer Center, Sheridan
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Walter Knox Memorial Hospital, Emmett
Saint Luke's Cancer Institute - Fruitland, Fruitland
Idaho Urologic Institute-Meridian, Meridian
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
Huntsman Cancer Institute/University of Utah, Salt Lake City
Cancer Center at Saint Joseph's, Phoenix
Mayo Clinic Hospital in Arizona, Phoenix
Lovelace Medical Center-Saint Joseph Square, Albuquerque
University of New Mexico Cancer Center, Albuquerque
Lovelace Radiation Oncology, Albuquerque
Cedars Sinai Medical Center, Los Angeles
Torrance Memorial Physician Network - Cancer Care, Torrance
Torrance Memorial Medical Center, Torrance
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
UC San Diego Moores Cancer Center, La Jolla
Sharp Memorial Hospital, San Diego
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
Mission Hope Medical Oncology - Santa Maria, Santa Maria
Epic Care-Dublin, Dublin
Epic Care Cyberknife Center, Walnut Creek
Bay Area Breast Surgeons Inc, Emeryville
Epic Care Partners in Cancer Care, Emeryville
Alta Bates Summit Medical Center - Summit Campus, Oakland
Bay Area Tumor Institute, Oakland
Clackamas Radiation Oncology Center, Clackamas
Providence Cancer Institute Clackamas Clinic, Clackamas
Providence Willamette Falls Medical Center, Oregon City
Providence Newberg Medical Center, Newberg
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Bay Area Hospital, Coos Bay
Saint Charles Health System, Bend
Saint Charles Health System-Redmond, Redmond
Saint Alphonsus Cancer Care Center-Baker City, Baker City
Saint Alphonsus Cancer Care Center-Ontario, Ontario
Saint Francis Hospital, Federal Way
Saint Elizabeth Hospital, Enumclaw
Swedish Cancer Institute-Edmonds, Edmonds
Swedish Cancer Institute-Issaquah, Issaquah
Pacific Gynecology Specialists, Seattle
Swedish Medical Center-Ballard Campus, Seattle
Swedish Medical Center-First Hill, Seattle
Highline Medical Center-Main Campus, Burien
Providence Regional Cancer Partnership, Everett
PeaceHealth Saint Joseph Medical Center, Bellingham
PeaceHealth United General Medical Center, Sedro-Woolley
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo
Saint Michael Cancer Center, Silverdale
Franciscan Research Center-Northwest Medical Plaza, Tacoma
Northwest Medical Specialties PLLC, Tacoma
Saint Clare Hospital, Lakewood
Providence Regional Cancer System-Lacey, Lacey
Anchorage Associates in Radiation Medicine, Anchorage
Providence Regional Cancer System-Aberdeen, Aberdeen
Providence Regional Cancer System-Centralia, Centralia
Providence Regional Cancer System-Shelton, Shelton
Providence Regional Cancer System-Yelm, Yelm
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Saint Mary Regional Cancer Center, Walla Walla
Anchorage Radiation Therapy Center, Anchorage
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Contra Costa Regional Medical Center, Martinez
Smilow Cancer Center/Yale-New Haven Hospital, New Haven
Yale University, New Haven
Mayo Clinic in Florida, Jacksonville
Advocate Christ Medical Center, Oak Lawn
Methodist West Hospital, West Des Moines
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Mercy Medical Center, Springfield
UMass Memorial Medical Center - University Campus, Worcester
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Morristown Medical Center, Morristown
Jersey Shore Medical Center, Neptune City
Capital Health Medical Center-Hopewell, Pennington
Overlook Hospital, Summit
Atrium Medical Center-Middletown Regional Hospital, Franklin
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Swedish Medical Center-Cherry Hill, Seattle
Collaborators (3)
National Cancer Institute (NCI)
NIH
Mirati Therapeutics Inc.
INDUSTRY
Genentech, Inc.
INDUSTRY
Eli Lilly and Company
INDUSTRY
Kazia Therapeutics Limited
INDUSTRY
Alliance for Clinical Trials in Oncology
OTHER