Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007

PHASE3CompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

March 21, 2019

Primary Completion Date

July 3, 2024

Study Completion Date

July 3, 2024

Conditions
Pyruvate Kinase Deficiency
Interventions
DRUG

AG-348

Participants will receive 5, 20, or 50 mg twice a day for up to 192 weeks (not including dose taper) unless the dose is modified for reasons related to safety.

Trial Locations (42)

1011

Centre Hospitalier Universitaire Vaudois (CHUV), Vaud (Lausanne)

2730

Herlev University Hospital, Herlev

8541

Toho University Omori Medical Center, Tokyo

10117

Charite - UB - CVK - Medizinische Klinik, Berlin

10700

Faculty of Medicine Siriraj Hospital, Bangkok

13385

Hospital La Timone, Marseille

16128

Ospedale Galliera, Genova

20122

Osp Maggiore Policlinico Milano, Milan

27710

Duke University Medical Center, Durham

28046

Hospital Universitario La Paz, Madrid

30120

Htal Clínico Universitario Virgen de la Arrixaca., Murcia

30322

Emory-Children's Center, Atlanta

31100

Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse

33000

CHU Hopitaux de Bordeaux - Hôpital Saint-André, Bordeaux

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

46260

Indiana Hemophilia & Thrombosis Center Inc., Indianapolis

48201

Wayne State University School of Medicine, Detroit

77030

Houston Methodist Research Institute, Houston

80318

"Università della Campania Luigi Vanvitelli", Napoli

84113

University of Utah, Salt Lake City

85016

Phoenix Children's Hospital, Phoenix

94010

CHU Hôpital Henri Mondor, Créteil

95609

UCSF Benioff Children's Hospital, Oakland, Oakland

97080

Universitätsklinik Würzburg, Würzburg

98195

Seattle Cancer Care Alliance, Seattle

02114

Massachusetts General Hospital, Boston

02115

Boston Children's Hospital, Boston

13083-878

UNICAMP - Hemocentro, São Paulo

L8N3Z5

McMaster University, Hamilton

Unknown

St James's Hospital, Dublin

00165

AORN Cardarelli, Napoli

514-8507

Mie University Hospital, Tsu

980-8574

Tohoku University Hospital, Sendai

615-8256

Kyoto Katsura Hospital, Kyoto

573-1010

Kansai Medical University, Dep. of Pediatrics, Hirakata Hospital, Osaka

3508 GA

Van Creveldkliniek, Utrecht

705-703

Yeungnam University Hospital, Daegu

08035

Hospital. U. Vall d'Hebron, Barcelona

06100

Hacettepe University Faculty of Medicine, Ankara

CB2 0QQ

Addenbrooke's Hospital, Cambridge

W2 INY

Imperial College Healthcare NHS Trust, London

WC1E 6BT

University College London, London

Sponsors
All Listed Sponsors
lead

Agios Pharmaceuticals, Inc.

INDUSTRY