Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure

PHASE3CompletedINTERVENTIONAL
Enrollment

195

Participants

Timeline

Start Date

January 24, 2019

Primary Completion Date

July 21, 2021

Study Completion Date

July 21, 2021

Conditions
Symptomatic Neurogenic Orthostatic Hypotension
Interventions
DRUG

ampreloxetine

Oral tablet, QD

DRUG

Placebo

Oral tablet, QD

Trial Locations (125)

1033

Clinexpert Kft., Budapest

1083

Semmelweis Egyetem, Budapest

1113

MHATNP Sv.Naum, EAD, Sofia

1160

Wilhelminenspital Wien Abteilung fur Neurologie, Vienna

1431

UMHAT Alexandrovska EAD Clinic of Neurological Diseases, Sofia

2139

Concord Hospital, Concord

2400

Bispebjerg og Frederiksberg Hospital, Copenhagen

2800

Szent Borbala Korhaz, Tatabánya

3050

The Royal Melbourne Hospital, Parkville

3168

Monash Health - Clinical Trials Centre, Clayton

3430

Universitätsklinikum Tulln, Tulln

4000

UMHAT Sveti Georgi EAD Clinic of Neurological Diseases, Plovdiv

4029

Royal Brisbane and Women's Hospital, Herston

5000

Odense Universitetshospital, Odense

5100

A.O. Santa Maria, Terni

6009

Perron Institute for Neurological and Translational Science, QEII Medical Centre, Nedlands

6020

Medizinische Universitat Innsbruck Abteilung Fur Neurologie, Innsbruck

7623

Pecsi Tudomanyegyetem, Neurologiai Klinika, Pécs

8011

New Zealand Brain Research Institute, Christchurch

10016

New York University Langone Health, New York

10138

East Tallinn Central Hospital, Tallinn

11009

Hospital Universitario Puerta del Mar, Cadiz

11315

Astra Team Clinic, Tallinn

13088

Alexianer St. Joseph-Krankenhaus Berlin-Weißensee, Klinik für Neurologie, Berlin

13353

Charite - Campus Virchow-Klinikum, Klinik fur Neurologie, Berlin

Charite - Campus Virchow-Klinikum, Berlin

20007

Georgetown University Hospital, Dept. of Neurology, Washington D.C.

20014

Hospital Universitario Donostia, San Sebastián

20089

Istituto Clinico Humanitas - IRCCS, Rozzano

20122

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milan

21005

CNE Acad O.I. Yushchenko Vinnytsia Reg Psychoneurological Hospital of Vinnytsia Regional Council, Department of Neurology, Vinnytsia

22101

Georgetown University Hospital, McLean

26655

Gemeinschaftspraxis Dr. med. J. Springub/ W. Schwarz, Westerstede

28006

Hospital Universitario de La Princesa, Madrid

28007

Hospital General Universitario Gregorio Marañon, Madrid

30029

CHU Caremeau, Nîmes

31008

Complejo Hospitalario de Navarra, Pamplona

Navarrabiomed Fundacion Miguel Servet, Pamplona

31059

Hospital Pierre Paul Rquet, CHU Purpan, Toulouse

32608

Fixel Institute for Neurological Diseases, Gainesville

33486

Parkinson's Disease and Movement Disorders Center, Boca Raton

33487

SFM Clinical Research, Boca Raton

33952

Neurostudies, Inc, Port Charlotte

37232

Vanderbilt University Medical Center, Nashville

40139

Universita di Bologna-Clinica Neurologica-Dipartimento di Scienze Neurologiche Ospedale Bellaria, Bologna

41013

Hospital Universitario Virgen del Rocio, Seville

43210

The Ohio State University Wexner Medical Center, Columbus

45219

University of Cincinnati Medical Center, Cincinnati

48903

Hospital de Cruces, Barakaldo

49005

Communal Institution Dnipropetrovsk I.I.Mechnikov RCH, Dnipro

50406

Tartu University Hospital, Tartu

55905

Mayo Clinic - Rochester, Rochester

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

60026

NorthShore University Health System, Glenview

60126

Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Umberto I - G.M. Lancisi - G. Salesi, SOD Clinica di Neuroriabilitazione, Ancona

60612

Rush University Medical Center, Chicago

61172

Communal Noncommercial Enterprise City Policlinic #9 of Kharkiv City Council, Kharkiv

66100

Universita Gabriele D'Annunzio- Cesi-Met, Chieti

66160

University of Kansas Medical Center, Kansas City

69035

Communal Institution City Clinical Hospital #6, Zaporizhzhia

75390

University of Texas Southwestern Medical Center, Dallas

79010

Communal Noncommercial Enterprise of Lviv Regional Council Lviv Regional Clinical Hospital Dept of Neurology, Lviv

79106

Universitaetsklinikum Freiburg - Klinik fur Neurologie und Neurophysiologie, Freiburg im Breisgau

80538

University of Colorado Health, Loveland

80907

Colorado Springs Neurological Associates, PC, Colorado Springs

84131

AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno

85351

Banner Sun Health Research Institute, Sun City

90015

Fondazione Istituto G.Giglio di Cefalù, Cefalù

90806

Collaborative Neuroscience Network, LLC, Long Beach

94304

Stanford Neuroscience Health Center, Palo Alto

95123

Azienda Ospedaliero - Universitaria Policlinico Vittorio Emanuele. - P.O G. Rodolico, Clinica Neurologica, Catania

97239

Oregon Health & Science University, Portland

99202

Inland Northwest Research, Spokane

125284

Federal State Budgetary Educational Institution of Additional Professional Education Russian Medical Academy of Continuous Postgraduate Education of the Ministry of Healthcare of the Russian Federation, Moscow

129128

NHI Central Clinical Hospital #2 of JSC Russian Railways N.A. Semashko, Moscow

192019

Federal State Budgetary Institution National Medical Research Centre of psychiatry and neurology named after V.M. Bekhterev of the Ministry of Healthcare of the Russian Federation, Saint Petersburg

197376

Human Brain Institute RAMS, Saint Petersburg

197706

Saint Petersburg State Budgetary Institution of Healthcare City Hospital # 40 of Kurortnyi Region, Saint Petersburg

214018

Regional State Budgetary Institution of Healthcare Smolensk Regional Clinical Hospital, Smolensk

420064

State Autonomous Institution of Healthcare Republican Clinical Hospital of the Ministry of Healthcare of Republic Tatarstan, Kazan'

630091

City Neurological Center Sibneiromed, Novosibirsk

SBEIHPE Novosibirsk State Medical University, Novosibirsk

660037

Federal State Budgetary Institution Federal Sibirian Scientific and Clinical Center of Federal Medico-Biological Agency, Krasnoyarsk

1311001

Ziv Medical Center, Safed

4941492

Rabin Medical Center, Petah Tikva

5262101

Chaim Sheba Medical Center, Tel Litwinsky

6423906

Tel Aviv Medical Center, Tel Aviv

7610001

Kaplan Medical Center, Rehovot

07103

Rutgers New Jersey Medical School, Newark

T2N 4Z6

University of Calgary, Calgary

N6A 5A5

London Health Sciences Centre-CCIT, London

M5T 2S8

University Health Network - Toronto Western Hospital Movement Disorders Clinic, Toronto

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

Unknown

Hopital Roger Salengro - CHU Lille, Lille

07551

Praxis Dr. Oehlwein, Gera

12 203

Charite Universitatsmedizin Berlin - Campus Benjamin Franklin, Berlin

58-20132

Ospedale San Raffaele I U.O. di Neurologia, Milan

00133

Fondazione PTV - Policlinico Tor Vergata I U.O.C. Neurologia, Roma

00148

Ospedale San Giovanni Battista del Sovrano Militare Ordine di Malta, Roma

Ospedale San Giovanni Battista, Roma

00161

Policlinico Umberto I - Universita degli Studi di Roma La Sapienza / Neurologia, Roma

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS / Istituto di Neurologia - Ambulatorio Disturbi del Movimento, Roma

00185

Sapienza University of Rome, Roma

40-588

Specjalistyczna Praktyka Lekarska prof.Grzegorz Opala, Katowice

30-510

PRATIA MCM Kraków, Krakow

31-505

Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii Klinicznej, Krakow

20-954

Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin

32-600

Instytut Zdrowia dr Boczarska-Jedynak, Oświęcim

41-100

NEURO-CARE Sp. z o.o. Sp. Komandytowa, Siemianowice Śląskie

02-777

ETG Warszawa, Warsaw

30-539

Specjalistyczne Gabinety sp. z o.o., Warsaw

4835-044

Hospital Senhora da Oliveira - Guimaraes, EPE, Guimarães

1649-035

Centro Hospitalar e Universitario Lisboa Norte - Hospital de Santa Maria, Lisbon

2560-280

Campus Neurologico Senior, Torres Vedras

08003

Hospital del Mar, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08222

Hospital Universitario Mutua de Terrasa, Barcelona

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

PL6 8BT

Re:Cognition Health, Plymouth

EC1A 7BE

Barts Hospital, London

WC1N 3BG

The National Hospital for Neurology & Neurosurgery, London

SES 9PJ

King's College Hospital, London

B16 8LT

Re:Cognition Health Ltd, Birmingham

W1G 9JF

Re:Cognition Health, London

M6 8HD

Salford Royal, Salford

Sponsors
All Listed Sponsors
lead

Theravance Biopharma

INDUSTRY

NCT03750552 - Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure | Biotech Hunter | Biotech Hunter