Small Molecules
Total Trials
75
As Lead Sponsor
54
As Collaborator
21
Total Enrollment
8,691
NCT00887406
Study of GSK961081 in Healthy Volunteer Subjects
Phase: Phase 1
Role: Lead Sponsor
Start: Nov 7, 2005
Completion: Oct 4, 2006
NCT00391820
Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation (ACCORD Trial)
Phase: Phase 2
Role: Collaborator
Start: Oct 31, 2006
Completion: May 31, 2007
NCT00442832
TD-1792 in Gram-positive Complicated Skin and Skin Structure Infection
Start: Dec 31, 2006
NCT00550225
Succinate Salt Version of GSK961081 for Healthy Volunteers
Start: Nov 29, 2007
Completion: Jan 8, 2008
NCT00687700
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
Start: Mar 10, 2008
Completion: May 27, 2008
NCT00674817
An Investigation Of The Interaction Of GSK961081 With Inhaled Beta-Agonist And Anti-Muscarinic Drugs.
Start: Apr 1, 2008
Completion: Oct 19, 2008
NCT01040637
A Multiple Dose Study of TD-1211 in Healthy Volunteers and Patients With Opioid-Induced Constipation
Phase: Phase 1/2
Start: Jan 31, 2010
Completion: Oct 31, 2010
NCT01321879
Study to Evaluate the Safety and Efficacy of Telavancin in the Treatment of Gram Positive Bloodstream Infections in Cancer Patients
Start: Mar 31, 2011
Completion: Dec 31, 2016
NCT01333540
A Study to Assess the Safety, Tolerability and Clinical Activity of TD-1211 in Patients With Opioid-Induced Constipation
Start: May 31, 2011
Completion: Jun 30, 2012
NCT03064113
Effects of TD-4208 on FEV1 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Completion: Oct 31, 2011
NCT01401985
A Study of TD-1211 in Subjects With Opioid-Induced Constipation (OIC)
Start: Oct 31, 2011
Completion: Aug 31, 2012
NCT01459926
A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Safety and Efficacy of TD-1211 in Subjects With Opioid-Induced Constipation
Start: Nov 30, 2011
NCT01467726
Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects
Completion: Jan 31, 2012
NCT01458340
A Study of TD-9855 in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
Start: Dec 31, 2011
Completion: Nov 30, 2013
NCT01568411
A Fixed-Sequence, Two-Period, Open-Label Drug-Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD-1211
Start: Apr 30, 2012
NCT01655771
TD-1211 Single-Dose Study in Elderly and Young Healthy Subjects
Start: Aug 31, 2012
Completion: Mar 31, 2013
NCT01644240
A Phase 1, Multiple Intravenous Dose Study to Examine Safety, Tolerability, and PK of Intravenous TD-8954, a 5-HT4 Receptor Agonist, in Healthy Subjects
Start: Sep 30, 2012
Completion: Dec 31, 2012
NCT01693692
Phase 2 Study of TD-9855 to Treat Fibromyalgia
Start: Nov 30, 2012
Completion: Apr 30, 2014
NCT01702194
TD-1211 IV/Oral Mass Balance Study
NCT01718938
Phase 2 Study of Velusetrag in Diabetic or Idiopathic Gastroparesis
Start: Dec 31, 2012
Completion: Feb 28, 2014
NCT01704404
7 Days of TD-4208 in Subjects With Chronic Obstructive Pulmonary Disease
Completion: Dec 31, 2013
NCT01791049
TD-1607 SAD Study in Healthy Subjects
Start: Apr 30, 2013
Completion: Oct 31, 2013
NCT01924143
TD-9855 Mass Balance Study
Start: Oct 31, 2013
NCT01949103
TD-1607 MAD Study in Healthy Subjects
Completion: Jul 31, 2014
NCT01953081
A Randomized, Double-Blind Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of a Single Dose of Intravenous TD-8954 Compared With Metoclopramide in Critically Ill Patients With Enteral Feeding Intolerance
Start: Jan 31, 2014
Completion: Oct 31, 2014
NCT02022306
TD-6450 SAD and MAD in Healthy Subjects
Start: Feb 28, 2014
Completion: Sep 30, 2014
NCT02109172
A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
Start: Apr 30, 2014
NCT02116543
TD-6450 MAD Study in HCV Infected Subjects
Start: May 31, 2014
Completion: Nov 30, 2014
NCT02040792
A 28-Day Parallel Group Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
Completion: Aug 31, 2014
NCT02267525
The Diabetic and Idiopathic Gastroparesis Efficacy, Safety, and Tolerability (DIGEST) Study
Start: Dec 31, 2014
Completion: Jun 30, 2017
NCT02772159
TD-4208 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
Start: Jun 30, 2015
Completion: Apr 30, 2016
NCT02392208
Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5
Phase: Phase 4
Start: Jul 31, 2015
Completion: Mar 31, 2016
NCT02459080
Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD)
Phase: Phase 3
Start: Sep 30, 2015
Completion: Sep 30, 2016
NCT02512510
NCT02518139
A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
NCT02639078
Single Ascending Dose Study of TD-0714 in Healthy Subjects
Start: Nov 30, 2015
Completion: Feb 29, 2016
NCT02581592
Pharmacokinetics of TD-4208 in Patients With Moderate Hepatic Impairment
NCT02657122
SAD and MAD Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of TD-1473 in Healthy Subjects
Start: Dec 31, 2015
NCT02578082
Pharmacokinetics of TD-4208 in Patients With Severe Renal Impairment
Completion: May 31, 2016
NCT02663089
A Phase 1 (Ph1), Single Dose (SD), GSK961081 Absorption, Distribution, Metabolism, and Excretion (ADME) Study in Healthy Subjects
Start: Feb 8, 2016
Completion: Mar 17, 2016
NCT02709928
Multiple Ascending Dose Study of TD-0714 in Healthy and Elderly Subjects
Start: Mar 31, 2016
NCT02753855
Pharmacokinetics of Telavancin in Normal and Obese Subjects
Start: Apr 30, 2016
Completion: Oct 31, 2016
NCT02820311
Thorough QT (TQT) Study of TD-4208 in Healthy Subjects
Start: May 31, 2016
Completion: Jul 31, 2016
NCT02903095
Single Ascending Dose Study of TD-1439 in Healthy Subjects
Start: Sep 30, 2016
Completion: Feb 28, 2017
NCT02818686
TD-1473 for Active Ulcerative Colitis (UC)
Start: Oct 3, 2016
Completion: Mar 29, 2018
NCT02954263
Multiple Ascending Dose Study of TD-1439 in Healthy Adult and Elderly Subjects
Start: Nov 30, 2016
Completion: Apr 30, 2017
NCT03095456
Revefenacin Peak Inspiratory Flow Rate (PIFR) Study in COPD
Start: Mar 27, 2017
Completion: Nov 25, 2017
NCT03103412
TD-3504 SAD in Healthy Subjects and Subjects With Ulcerative Colitis (UC)
Start: May 4, 2017
Completion: Nov 8, 2017
NCT02705755
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)
Start: Sep 9, 2017
Completion: Nov 28, 2018
NCT03408470
TD-1473 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
Start: Jan 31, 2018
Completion: Feb 21, 2018
NCT03432793
Drug-Drug Interaction (DDI) Study for TD-9855
Start: Feb 28, 2018
Completion: Apr 21, 2018
NCT03573817
A 42-day Parallel Group Safety Study of Revefenacin and Formoterol, Administered in Sequence and as a Combination, in Participants With COPD
Start: May 31, 2018
Completion: Sep 25, 2018
NCT03555617
Food-effect, Drug-Drug Interaction (DDI), and Formulation Bridging Study
Start: Jun 13, 2018
Completion: Jul 15, 2018
NCT03652038
Single and Multiple Ascending Dose Study of TD-8236 by Inhalation
Start: Nov 7, 2018
Completion: Jul 13, 2020
NCT03635112
Efficacy and Safety of TD-1473 in Crohn's Disease
Start: Nov 19, 2018
Completion: Dec 30, 2021
NCT03750565
Multiple Dose Ethnobridging PK Study in Healthy Subjects
Start: Nov 27, 2018
Completion: Feb 13, 2019
NCT03750552
Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
Start: Jan 24, 2019
Completion: Jul 21, 2021
NCT03829657
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
Start: Feb 22, 2019
Completion: Nov 10, 2021
NCT03758443
Efficacy & Safety of TD-1473 in Ulcerative Colitis
Phase: Phase 2/3
Start: Mar 11, 2019
Completion: Oct 20, 2021
NCT04044339
Single and Multiple Ascending Dose, First-in- Human Study in Healthy Subjects
Start: Aug 8, 2019
Completion: Nov 27, 2019
NCT04095793
Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure
Start: Sep 19, 2019
Completion: Nov 12, 2021
NCT04150341
Effect of Inhaled TD-8236 on Allergen-induced Asthmatic Response
Start: Nov 6, 2019
Completion: Sep 3, 2020
NCT04200573
Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of TD-9855
Start: Jan 13, 2020
Completion: Aug 19, 2021
NCT04350736
First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19
Start: Apr 23, 2020
Completion: Jul 1, 2020
NCT04402866
TD-0903 for ALI Associated With COVID-19
Start: Jun 24, 2020
Completion: Apr 21, 2021
NCT03920254
TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) Study
Start: Jul 23, 2020
Completion: Oct 27, 2021
NCT04589260
TD-1058 First-In-Human Study in Healthy Subjects and Subjects With Idiopathic Pulmonary Fibrosis
Start: Oct 15, 2020
Completion: Oct 4, 2021
NCT04587713
Single Dose Bioavailability and Ethnobridging PK Study in Healthy Subjects
Start: Oct 16, 2020
Completion: Dec 27, 2020
NCT04315558
Revefenacin in Acute Respiratory Insufficiency in COPD
Start: Nov 1, 2020
Completion: Jan 1, 2025
NCT04688632
Thorough QT Study to Evaluate Ampreloxetine in Healthy Subjects
Start: Jan 18, 2021
Completion: Mar 26, 2021
NCT04681079
Comparison of Viral Particle Dispersion Following Administration of an MDI or Nebulizer in Subjects With COVID-19
Phase: N/A
Start: May 4, 2021
Completion: Jan 18, 2022
NCT05091723
TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation
Start: Oct 13, 2021
Completion: Nov 24, 2021
NCT05165485
Phase 4 COPD and Suboptimal Inspiratory Flow Rate
Start: Jan 7, 2022
Completion: Nov 20, 2023
NCT05696717
Phase 3 Efficacy and Durability of Ampreloxetine for the Treatment of Symptomatic nOH in Participants With Multiple System Atrophy
Start: Jun 27, 2023
Completion: Jan 31, 2028
NCT07133880
Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
Start: Dec 5, 2023
Completion: Dec 1, 2025
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