Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients

PHASE3TerminatedINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

October 14, 2019

Primary Completion Date

April 8, 2024

Study Completion Date

April 8, 2024

Conditions
Antibody-mediated Rejection
Interventions
BIOLOGICAL

Clazakizumab

Clazakizumab is a genetically engineered humanized immunoglobulin G1 (IgG1) mAb that binds to human IL-6

DRUG

Physiologic saline solution

Normal saline

Trial Locations (142)

2050

Royal Prince Alfred Hospital, Camperdown

2145

WSLHD, Westmead Hospital, Westmead

3064

The Royal Melbourne Hospital, Parkville

3168

Monash Health Monash Medical Centre, Clayton

4032

Debreceni Egyetem, Klinikai Központ, Auguszta, Debrecen

4102

Princess Alexandra Hospital, Woolloongabba

The University of Queensland - Princess Alexandra Hospital (PAH), Woolloongabba

6009

Sir Charles Gairdner Hospital (SCGH), Nedlands

8003

Hospital Del Mar, Barcelona

8035

Hospital Vall d'Hebron, Barcelona

8036

Hospital Clinic Barcelona, Barcelona

8907

Hospital Universitari de Bellvitge, Barcelona

10016

NYU Langone Medical Center, New York

10021

New York Presbyterian Hospital / Weill Cornell Medical Center, New York

10032

Columbia University Medical Center, New York

10117

Charite - Universitaetsmedizin Berlin - Campus Charite Mitte (CCM), Berlin

13005

Hopital de la Conception - APHM, Marseille

14000

IKEM, Prague

14215

Erie County Medical Center Corp., Buffalo

17104

Central Pennsylvania Transplant Foundation, Harrisburg

18103

Lehigh Valley Health Network, Allentown

19104

University of Pennsylvania, Philadelphia

19107

Jefferson University Hospital, Philadelphia

23298

VCU Health, Richmond

27157

Wake Forest University Health Sciences, Winston-Salem

27710

Duke Cancer Institute, Durham

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre-Centro de Actividades Ambulatorias, Madrid

31059

CHU Rangueil, Toulouse

33076

Centre Hospitalier Universitaire (CHU) de Bordeaux - Groupe Hospitalier Pellegrin, Bordeaux

33606

Tampa General Medical Group, Tampa

34295

Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve, Montpellier

35294

University of Alabama at Birmingham (UAB) - University of Alabama Hospital (UAB Hospital), Birmingham

37044

Centre Hospitalier Regional Universitaire de Tours (CHRU de Tours) - Hopital Bretonneau, Tours

38043

CHU GRENOBLE ALPES - Consultation Néphrologie Bureau des ARC (Côté Chartreuse, Rez-de-Chaussée Haut), Grenoble

39008

Hospital Universitario Marques De Valdecilla, Santander

40202

University of Louisville Research Foundation, Louisville

43210

The Ohio State University, Comprehensive Transplant Center, Columbus

43614

University of Cincinnati, Toledo

44093

CHU de Nantes - Houtel Dieu, Nantes

46017

Centro Hospital Universitario Dr. Preset, Valencia

46202

Indiana University (IU) Health Physicians - Kidney Diseases Clinic - Medical Diagnostic Center Location, Indianapolis

48202

Henry Ford Health System, Detroit

50009

Hospital Universitario Miguel Servet, Zaragoza

50309

Unity Point Health, Des Moines

52242

Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City

53226

Medical College of WI Froedtert Hospital, Milwaukee

53705

University of Wisconsin School of Medicine and Public Health (UWSMPH), Madison

55095

Mayo Clinic, Rochester

55455

University of Minnesota, Minneapolis

60611

Northwestern Memorial Hospital, Chicago

60612

Rush University Medical Center - University Cardiovascular Surgeons, Chicago

63110

Washington University School of Medicine - Infectious Diseases (WU ID) Clinic, St Louis

67098

Hopitaux Universitaire de Strasbourg-Centre de References des Maladies Autoimmunes, Strasbourg

68105

University of Nebraska Medical Center, Omaha

69003

Hopital Edouard Herriot, Lyon

70112

Tulane University Health Sciences Center, New Orleans

73112

Integris Baptist Medical Center, Oklahoma City

75010

Hospital Saint-Louis - APHP, Paris

75015

Hopital Necker Enfants Malades, Paris

75185

Uppsala Universitet - Akademiska Sjukhuset, Uppsala

75204

Renal Disease Research Institute, Dallas

75235

UT Southwestern Medical Center, Dallas

76230

Néphrologie - Pavillon Sainte Venise - CHU de Rouen - Hôpital de Bois Guillaume, Bois-Guillaume

78229

Methodist Healthcare System of San Antonio, San Antonio

80045

University Of Colorado Hospital - Anschutz Medical Campus, Aurora

85054

Mayo Clinic Hospital, Phoenix

86021

Centre Hospitalier Universitaire de Poitiers, Poitiers

87042

Centre Hospitalier Universitaire (CHU) De Limoges Hopital Dupuytren, Limoges

90033

Keck Medical Center Of USC, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90095

UCLA Kidney Transplant Research Program, Los Angeles

91773

North America Research Institute, San Dimas

92123

California Institute of Renal Research, San Diego

94010

Centre Hospitalier Universitaire (CHU) - Hopital Henri Mondor, Créteil

94109

California Pacific Medical Center, San Francisco

94118

Kaiser Permanente, San Francisco

94143

University of California, San Francisco Medical Center, San Francisco

94270

Hopital Kremlin Bicetre, Le Kremlin-Bicêtre

95817

University of California Davis Medical Center, Sacramento

98195

University of Washington, Seattle

02114

Massachusetts General Cancer Center, Boston

02215

Beth Israel Deaconess Medical Center, Boston

07039

Saint Barnabas Medical Center, Livingston

02906

Rhode Island Hospital, Providence

Unknown

Royal Adelaide Hospital, Adelaide

Royal Prince Alfred Hospital, Camperdown

Monash Medical Centre, Clayton

Linear Clinical Research, Nedlands

Westmead Hospital, Westmead

Princess Alexandra Hospital, Woolloongabba

LKH-Universität Hospital Graz, Graz

Universitätsklinik für Innere Medizin III Innsbruck, Innsbruck

Medizinische Universität Wien, Allgemeines Krankenhaus der S, Vienna

UZ Antwerpen, Edegem

UZ Leuven, Leuven

Centre Hospitalier Universitaire Sart Tilman, Liège

Centre de Recherche du Centre Hospitalier de l'Universite de Montreal (CRCHUM), Montreal

University Health Network, Toronto

Centrum kardiovaskulární a transplantacní chirurgie Brno, Brno střed

Fakultní Nemocnice Olomouc, Olomouc

Debreceni Egyetem Klinikai Kozpont, Debrecen

Radboud UMC, Nijmegen

Erasmus University Medical Center, Rotterdam

Universitair Medisch Centrum Utrecht, Utrecht

Auckland City Hospital, Auckland

Pusan National University Hospital, Busan

Keimyung Dongsan Medical Center, Daegu

Asan Medical Center, Seoul

Kangdong Sacred Heart Hospital, Seoul

Korea University Anam Hospital, Seoul

Kosin University Gospel Hospital, Seoul

Kyung Hee University Hospital at Gangdong, Seoul

Samsung Medical Center, Seoul

Seoul National University Bundang Hospital, Seoul

Seoul National University Hospital, Seoul

Severance Hospital Yonsei University, Seoul

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

Pusan National University Yangsan Hospital, Yangsan

Karolinska University Hospital, Solna

Uppsala Universitet - Akademiska Sjukhuset, Uppsala

Hualien Tzu Chi Hospital, Hualien City

Far Eastern Memorial Hospital, New Taipei City

Taichung Veterans General Hospital, Taichang

National Taiwan University Hospital, Taipei

Linkou Chang Gung Memorial Hospital, Taoyuan District

V5Z 1M9

Vancouver General Hospital - Gordon & Leslie Diamond Centre, Vancouver

V6Z 1Y6

St. Paul's Hospital, Providence Health Care, Univ. Of British Columbia, Vancouver

R3A 1R9

Shared Health Inc. operating as the Health Sciences Centre, Winnipeg

B3H 1V7

Queen Elizabeth II Health Sciences Centre, Halifax

N6A 5A5

London Health Sciences Centre, London

M5C 2T2

St. Michael's Health Centre, Toronto

H4A 3J1

McGill University Health Center, Montreal

S7M 0Z9

St Paul's Hospital Foundation, Saskatoon

06001

Centre Hospitalier Universitaire de Nice, Hopital Pasteur 2, Nice

1105 AZ

Amsterdam University Medical Center (Amsterdam UMC), Academic Medical Center (AMC), Amsterdam

1105AZ

Amsterdam UMC location AMC, Amsterdam

9713 GZ

University Medical Center Groningen, Groningen

2333 ZA

Leiden University Medical Center (LUMC), Leiden

6248 HX

Maastricht University Medical Centre, Maastricht

SE-141 86

Karolinska University Hospital, Huddinge

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

ICON Clinical Research

INDUSTRY

lead

CSL Behring

INDUSTRY