A Study of the Intra-Patient Escalation Dosing Regimen With IMCgp100 in Patients With Advanced Uveal Melanoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

February 29, 2016

Primary Completion Date

March 20, 2020

Study Completion Date

October 17, 2022

Conditions
Uveal Melanoma
Interventions
DRUG

IMCgp100

Bispecific soluble HLA-A2 restricted gp100-specific T-cell receptor fused to anti-CD3

Trial Locations (26)

10032

Columbia University Medical Center - The New York Presbyterian Hospital, New York

10065

Memorial Sloan Kettering Hospital, New York

12200

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin

14263

Roswell Park Cancer Institute, Buffalo

19107

Thomas Jefferson University Medical Oncology Clinic, Philadelphia

20007

Georgetown University - Lombardi Comprehensive Cancer Center, Washington D.C.

28046

Hospital Universitario La Paz, Madrid

33136

University of Miami Hospital Clinics/Sylvester Comprehensive Cancer Center, Miami

37232

Vanderbilt University Medical Center, Nashville

41009

Hospital Universitario Virgen Macarena, Seville

46014

Hospital General Universitario de Valencia, Valencia

60637

The University of Chicago Medical Center, Chicago

63110

Washington University, School of Medicine, St Louis

69120

Universitaetsklinikum Heidelberg, Heidelberg

73104

Dean A. Mcgee Eye Institute, Oklahoma City

76508

Baylor Scott & White Health, Temple

80045

University of Colorado Denver Anschutz Medical Campus, Aurora

90025

The Angeles Clinic and Research Institute - W LA Office, Los Angeles

92093

University California, San Diego Moores Cancer Center, La Jolla

94115

California Pacific Medical Center, San Francisco

97213

Providence Portland Medical Center, Portland

33612-9497

H. Lee Moffitt Cancer Center and Research Institute, Inc, Tampa

M5G2M9

Princess Margaret Cancer Center, Toronto

08908

ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat

CH63 4JY

The Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

HA6 2RN

Mount Vernon Cancer Centre, Northwood

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Immunocore Ltd

INDUSTRY

NCT02570308 - A Study of the Intra-Patient Escalation Dosing Regimen With IMCgp100 in Patients With Advanced Uveal Melanoma | Biotech Hunter | Biotech Hunter