221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,653

Participants

Timeline

Start Date

August 13, 2015

Primary Completion Date

August 8, 2019

Study Completion Date

August 8, 2019

Conditions
Alzheimer's Disease
Interventions
DRUG

Aducanumab (BIIB037)

Low dose

DRUG

Aducanumab (BIIB037)

High dose

DRUG

Placebo

Placebo

Trial Locations (181)

100

National Taiwan University Hospital, Taipei

333

Chang Gung Memorial Hospital, Linkou, Taoyuan

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

2010

St Vincent's Hospital Sydney, Darlinghurst

2100

Rigshospitalet, København Ø

2113

KARA Institute for Neurological Diseases, North Ryde

2250

Central Coast Neurosciences Research, Gosford, East Gosford

Central Coast Neurosciences Research, Erina

2298

Calvary Mater Newcastle, Waratah

2750

CCBR - Ballerup - DK, Ballerup Municipality

3050

Royal Melbourne Hospital, Parkville

3084

Austin Hospital, Heidelberg

3128

Box Hill Hospital, Box Hill

4006

Royal Brisbane and Women's Hospital, Herston

4032

The Prince Charles Hospital, Chermside

4350

Toowoomba Base Hospital, Toowoomba

5020

Christian-Doppler-Klinik - Universitätsklinikum Salzburg, Salzburg

6005

Neurodegenerative Disorders Research, West Perth

7100

CCBR - Vejle - DK, Vejle

8036

LKH - Universitaetsklinikum Graz, Graz

9100

CCBR - Ålborg - DK, Aalborg

10016

New York University Medical Center PRIME, New York

12208

Albany Medical College, Albany

13620

Seoul National University Bundang Hospital, Seongnam-si

14050

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin, Berlin

14620

University of Rochester, Rochester

15213

University of Pittsburgh, Pittsburgh

16132

Azienda Ospedaliero Universitaria San Martino, Genova

18705

Northeastern Pennsylvania Memory and Alzheimer's Center, Plains

19046

The Clinical Trial Center, LLC, Jenkintown

20014

Policlinica Guipuzcoa, Donostia / San Sebastian

20057

Georgetown University Hospital, Washington D.C.

20132

Ospedale San Raffaele, Milan

20144

Casa di Cura del Policlinico, Milan

21565

Gachon University Gil Medical Center, Incheon

22332

Inha University Hospital, Incheon

23294

National Clinical Research Inc.-Richmond, Richmond

24100

Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo

25100

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

28006

Clinica Ruber, Madrid

28270

ANI Neurology, PLLC d/b/a Alzheimer's Memory Center, Charlotte

29425

Medical University of South Carolina (MUSC), Charleston

30159

Klinische Forschung Hannover-Mitte GmbH, Hanover

32162

Compass Research Main, The Villages

32216

Jacksonville Center for Clinical Research, Jacksonville

32806

Compass Research Main, Orlando

33076

Groupe Hospitalier Pellegrin - Hôpital Pellegrin, Bordeaux

33136

University of Miami, Miami

33137

Miami Jewish Health Systems, Miami

33331

Cleveland Clinic Florida - Weston, Weston

33407

Premiere Research Institute, West Palm Beach

33410

Palm Beach Neurological Center, Palm Beach Gardens

33445

Brain Matters Research, Inc., Delray Beach

33613

Stedman Clinical Trials, LLC, Tampa

33616

USF Health Byrd Institute, Tampa

33634

Meridien Research, Tampa

33912

Neuropsychiatric Research Center of Southwest Florida, Fort Myers

34121

Neurologische Gemeinschaftspraxis Kassel, Kassel

37920

University of Tennessee Medical Center. Knoxville, Knoxville

38108

Neurology Clinic, PC, Cordova

38119

Clinical Neuroscience Solutions, Inc., Memphis

40503

Baptist Health Lexington, Lexington

44195

Cleveland Clinic, Cleveland

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

46202

Indiana University School of Medicine, Indianapolis

46804

Fort Wayne Neurological Center, Fort Wayne

48903

Hospital de Cruces, Barakaldo

51092

CHU Reims - Hôpital Maison Blanche, Reims

52074

Universitaetsklinikum Aachen AOeR, Aachen

53100

A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena

53105

Universitaetsklinikum Koeln, Cologne

53127

Universitaetsklinikum Bonn AoeR, Bonn

53266

Medical College of Wisconsin, Inc., Milwaukee

55905

Mayo Clinic, Rochester

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

60007

Alexian Brothers Neurosciences Institute, Elk Grove Village

60068

Advocate Lutheran General Hospital, Park Ridge

60126

Azienda Ospedaliero Universitaria Ospedali Riuniti, Torrette Di Ancona

63131

Washington University, St Louis

66160

University of Kansas Medical Center Research Institute, Inc., Kansas City

67091

Hopital Louis Pasteur Colmar, Strasbourg

67098

CHU Strasbourg - Hôpital Hautepierre, Strasbourg

67214

Via Christi Research, a division of Via Christi Hospitals Wichita, Inc., Wichita

69677

Hopital Neurologique Pierre Wertheimer, Bron

70182

Neuro MVZ Stuttgart, Stuttgart

71034

Praxis Dr. Scholz, Böblingen

73112

Lynn Health Science Institute, Oklahoma City

73760

Aerztliche Gemeinschaftspraxis, Ostfildern

75013

Groupe hospitalier Broca - La Rochefoucauld - La Collégiale, Paris

Groupe Hospitalier Pitie-Salpetriere, Paris

75390

UT Southwestern Medical Center at Dallas, Dallas

77030

Baylor College of Medicine, Houston

80131

"Azienda Ospedaliera Universitaria Federico II", Napoli

80138

Seconda Università degli Studi di Napoli, Napoli

83301

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

84131

Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona, Salerno

85013

St. Joseph's Hospital and Medical Center, Phoenix

85718

Center for Neurosciences, Tucson

86633

Praxis Dr. med. Bergmann, Neuburg am Inn

89113

Las Vegas Medical research, Las Vegas

90015

Fondazione Istituto G.Giglio di Cefalù, Cefalù

90095

University of California - Los Angeles, Los Angeles

90717

Torrance Clinical Research Institute, Inc., Lomita

91403

California Neuroscience Research Medical Group Inc., Sherman Oaks

92653

Senior Clinical Trials, Inc., Laguna Hills

92835

Neurology Center of North Orange County, Fullerton

93065

Southern California Research LLC, Simi Valley

94158

UCSF - Memory and Aging Center, San Francisco

97080

Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt

06510

Institute for Neurodegenerative Disorders, New Haven

02115

Brigham & Women's Hosp End/Dbt, Boston

02215

Beth Israel Deaconess Medical Center, Boston

01844

ActivMed Practices & Research, Methuen

02360

Donald S. Marks, M.D., P.C., Plymouth

08755

Advanced Memory Research Institute of NJ, PC, Toms River

27607-6010

Raleigh Neurology Associates, P.A., Raleigh

02915

Rhode Island Mood & Memory Research Institute, East Providence

02906

Butler Hospital, Providence

T2N 1N4

Heritage Medical Research Clinic, Calgary

V2A 5C8

The Medical Arts Health Research Group, Penticton

V6T 2B5

UBC Hospital, Vancouver

M3B 2S7

Toronto Memory Program (Neurology Research Inc.), Toronto

M4N 3M5

Toronto Sunnybrook Hospital, Toronto

H3A 2B4

The Montreal Neurological Institute, Montreal

H4H 1R3

McGill Centre for Studies in Aging, Verdun

G1J 1Z4

CHU de Quebec - Hôpital de l' Enfant Jésus, Québec

00168

Policlinico Universitario Agostino Gemelli, Roma

263-0043

Research Site, Chiba

Unknown

Research Site, Inzai-shi

Research Site, Kiyose-shi

830-0011

Research Site, Kurume-shi

965-8585

Research Site, Aizuwakamatsu-shi

070-8644

Research Site, Asahikawa-shi

006-8555

Research Site, Sapporo

064-8570

Research Site, Sapporo

243-8551

Research Site, Atsugi-shi

247-8533

Research Site, Kamakura-shi

211-8533

Research Site, Kawasaki-Shi

223-0059

Yokohama

225-0013

Research Site, Yokohama

225-0025

Research Site, Yokohama

616-8255

Research Site, Kyoto

940-2081

Research Site, Nagaoka-shi

350-0495

Research Site, Iruma-gun

344-0036

Research Site, Kasukabe-shi

143-8541

Research Site, Ōta-ku

113-0034

Research Site, Bunkyō City

162-8655

Research Site, Shinjuku-ku (I)

Research Site, Shinjuku-ku

990-0834

Research Site, Yamagata

173-0015

Research Site, Itabashi-ku

173-8610

Research Site, Itabashi-ku

187-8551

Research Site, Kodaira-shi

2720-276

Hospital Professor Doutor Fernando Fonseca, E.P.E., Amadora

4710-243

Hospital de Braga, Braga

3040-278

Centro Hospitalar e Universitário de Coimbra E.P.E, Coimbra

1600-618

CUF Alvalade, Lisbon

2674-514

Hospital Beatriz Ângelo, Loures

2560-280

Campus Neurologico Senior, Torres Vedras

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

143-729

Konkuk University Medical Center, Seoul

08028

Fundacio ACE, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

BS16 1LE

Southmead Hospital, Bristol

W1G 9JF

Re:Cognition Health Ltd, London

W6 8RF

Charing Cross Hospital, London

WC1N 3BG

The National Hospital for Neurology and Neurosurgery Centre, London

M6 8HD

Salford Royal, Salford

EH8 9YL

The University of Edinburgh, Edinburgh

BB3 2HH

Manchester Royal Infirmary, Blackburn

BA1 3NG

The RICE Centre, Bath

G20 0XA

Glasgow Memory Clinic Ltd, Glasgow

G21 3UW

Stobhill ACH Hospital, Glasgow

DD2 1GZ

Ninewells Hospital, Dundee

NE4 5PL

Newcastle University, Newcastle upon Tyne

SN15 1GG

Kingshill Research Centre, Chippenham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY