Aggressive Fever Control With Intravenous Ibuprofen After Non-traumatic Brain Hemorrhage

PHASE4TerminatedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

October 31, 2012

Primary Completion Date

March 17, 2016

Study Completion Date

March 17, 2016

Conditions
Fever
Interventions
DRUG

Intravenous Ibuprofen

Ibuprofen 400 mg/100 mL intravenous (IV) over 30 minutes, followed by a continuous infusion of 2000 mg/500 mL at 85 mg/hour (21 mL/hour) for up to post bleed day 14 or discharge from the Neuro ICU, whichever comes first

DRUG

Acetaminophen (Standard of Care)

Acetaminophen 650 mg via oral/nasogastric tube every 6 hours as needed for T\>=38.3 C (100.9 F) for up to post bleed day 14 or discharge from the Neuro ICU, whichever comes first.

Trial Locations (1)

10032

Columbia University Medical Center, New York

Sponsors
All Listed Sponsors
collaborator

Cumberland Pharmaceuticals

INDUSTRY

lead

Columbia University

OTHER