Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity

PHASE2CompletedINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

June 30, 2009

Primary Completion Date

November 15, 2017

Conditions
Colorectal CancerLiver MetastasesIrradiation DamageRadiation Induced Liver Disease
Interventions
DRUG

Pentoxifylline

Pentoxifylline is given for 8 weeks since the evening of the day of intervention with a dose of 400mg applied three times daily (morning, noon, evening).

DRUG

Ursodeoxycholic Acid

Ursodeoxycholic acid is administered for 8 weeks since the evening of the day of intervention. Dosage is 250mg given three times daily (morning, noon, evening).

DRUG

Enoxaparin

Enoxaparin with a dose of 40mg is injected subcutaneously once a day for 8 weeks since the evening of the day of intervention after the HDR-brachytherapy.

Trial Locations (1)

39120

Clinic for Radiology and Nuclear Medicine, Magdeburg

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Sirtex Medical

INDUSTRY

lead

University of Magdeburg

OTHER