Erlotinib (Tarceva) and Bexarotene (Targretin) Oral Capsules in Advanced Cancers of the Aerodigestive Tract

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

April 30, 2003

Primary Completion Date

April 30, 2014

Study Completion Date

April 30, 2014

Conditions
Advanced, Malignant Aerodigestive Tract Tumor (Lung, Head and Neck and Esophagus)
Interventions
DRUG

Bexarotene (Targretin®)

Level -I 200 mg/m2 Level I 300 mg/m2 Level II 300 mg/m2 Level III 400 mg/m2

DRUG

Erlotinib (Tarceva™)

Level -1 100mg Level I 100mg Level II 150mg Level III 150mg

Trial Locations (1)

03756

Dartmouth-Hitchcock Medical Center, Lebanon

Sponsors
All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Ligand Pharmaceuticals

INDUSTRY

lead

Dartmouth-Hitchcock Medical Center

OTHER