Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

PHASE3CompletedINTERVENTIONAL
Enrollment

420

Participants

Timeline

Start Date

July 31, 2008

Primary Completion Date

October 30, 2009

Study Completion Date

December 31, 2009

Conditions
Renal InsufficiencyCongestive Heart Failure
Interventions
DRUG

tonapofylline

IV

DRUG

Placebo

IV

Trial Locations (189)

29

Hus

1202

Sofia

1309

Sofia

1527

Sofia

1606

Sofia

2010

Darlinghurst

2170

Liverpool

3000

Santa Fe

3004

Melbourne

3175

Dandenong

4000

San Miguel de Tucumán

4289

Leipzig

4400

Pazardzhik

5800

Pleven

10021

New York

10461

The Bronx

11501

Mineola

11794

Stony Brook

13100

Safed

13790

Johnson City

14033

Caen

15850

Lahti

16000

Nazareth

17011

Camp Hill

17603

Lancaster

17822

Danville

18901

Doylestown

19140

Philadelphia

20125

Bucharest

20162

Milan

20520

Turku

21201

Baltimore

21659

Bucharest

22100

Nahariya

22328

Bucharest

24541

Danville

25304

Charleston

28025

Concord

29118

Orangeburg

31059

Toulouse

31096

Haifa

32216

Jacksonville

33613

Tampa

34239

Sarasota

35801

Huntsville

36608

Mobile

37208

Nashville

37388

Tullahoma

37830

Oak Ridge

43210

Columbus

44195

Cleveland

44281

Kfar Saba

45005

Franklin

45267

Cincinnati

46100

Mantova

46202

Indianapolis

47303

Muncie

49100

Petah Tikva

49684

Traverse City

52242

Iowa City

53185

Lidköping

55404

Minneapolis

58100

Holon

59208

Tourcoinq

60148

Lombard

60220

Seinäjoki

60488

Frankfurt am Main

63128

St Louis

64063

Lee's Summit

64132

Kansas City

Kansas City

64239

Tel Aviv

67091

Strasbourg

67220

Wichita

68131

Omaha

70300

Beer Yaakov

72917

Fort Smith

73109

Oklahoma City

73120

Oklahoma City

74104

Tulsa

75216

Dallas

76692

Whitney

77030

Houston

78215

San Antonio

78306

Ashkelon

81000

Albi

90210

Beverly Hills

90220

Oulu

90277

Redondo Beach

90502

Torrance

91031

Jerusalem

91120

Jerusalem

91240

Jerusalem

91342

Sylmar

91754

Monterey Park

91911

Chula Vista

92056

Oceanside

92103

San Diego

92691

Mission Viejo

95300

Pontoise

95991

Yuba City

97213

Portland

98405

Tacoma

98506

Olympia

110055

Delhi

110060

New Delhi

113093

Moscow

123182

Moscow

125101

Moscow

127473

Moscow

127644

Moscow

192242

Saint Petersburg

193318

Saint Petersburg

198205

Saint Petersburg

199106

Saint Petersburg

334003

Bikaner

410028

Saratov

411004

Pune

452018

Indore

560034

Bangalore

562158

Bangalore

600037

Chennai

600114

Bacau

630008

Novosibirsk

630075

Novosibirsk

630090

Novosibirsk

634012

Tomsk

650002

Kemerovo

656099

Barnaul

660062

Krasnoyarsk

680002

Thrissur

06102

Hartford

01432

Ayer

02114

Boston

02601

Hyannis

01107

Springfield

01089

West Springfield

07450

Ridgewood

02908

Providence

B1605DSX

Buenos Aires

B1722COV

Buenos Aires

C1280AEB

Capital Federal

W3400AMZ

Corrientes

X5004CDT

Córdoba

X5009BSN

Villa Cabrera

S3000FUJ

Santa Fe

D5702JRS

San Luis

C1437JCP

Capital Federal

ACT 2605

Canberra

60864-190

Fortaleza

90110-270

Porto Alegre

49015-400

Aracaju

09190-610

Santo André

15015-210

São José do Rio Preto

79080-190

Campo Grande

80010-030

Curitiba

90620-001

Porto Alegre

CEP 90350-200

Porto Alegre

50100-010

Recife

V5Z 1M9

Vancouver

E2L 4L2

Saint John

280 20

Kolín

686 68

Uherské Hradiště

92 92166

Antony

49 49325

Cholet

75 75651

Paris

86 86021

Poitiers

HE 61231

Bad Nauheim

BE 12559

Berlin

BE 13353

Berlin

NW 44791

Bochum

NW 45138

Essen

HE 60590

Frankfurt

NI 37075

Göttingen

BY 93042

Regensburg

NW 42117

Wuppertal

PV 27100

Pavia

6229 HX

Maastricht

2512 VA

The Hague

8011 JW

Zwolle

83-400

Kościerzyna

10-045

Olsztyn

76-200

Słupsk

33-100

Tarnów

00-909

Warsaw

04-628

Warsaw

50-981

Wroclaw

51-124

Wroclaw

413 45

Gothenburg

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY

NCT00709865 - Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency | Biotech Hunter | Biotech Hunter