Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers

oral administration of BIIB014, given once daily for 8 to 12 consecutive days, at various doses as specified in protocol

11C\]SCH442416 is a radiolabelled tracer molecule that specifically binds to adenosine A2A sites and will be used to evaluate receptor occupancy. The target activity will be 370 MBq. \[11C\]SCH442416 will be administered IV as a bolus injection over 30 seconds following the start of each PET scan.