Defunct Company
Total Trials
18
As Lead Sponsor
As Collaborator
0
Total Enrollment
1,319
NCT00216463
Safety and Tolerability of Varying Load and Dose of ISIS 301012 in People With Elevated LDL-cholesterol Levels
Phase: Phase 2
Role: Lead Sponsor
Start: Aug 31, 2005
Completion: Aug 31, 2007
NCT00231569
Dose-escalating Safety Study in Subjects on Stable Statin Therapy
Start: Sep 30, 2005
Completion: Dec 31, 2007
NCT00280995
Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy
Start: Jan 31, 2006
NCT00281008
Study of ISIS 301012 (Mipomersen) in Heterozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy
Start: Feb 28, 2006
NCT00362180
Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration
Start: Jul 31, 2006
Completion: Sep 30, 2010
NCT00477594
Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial Hypercholesterolemia
Start: May 31, 2007
Completion: Jul 31, 2011
NCT00607373
Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial Hypercholesterolemia
Phase: Phase 3
Start: Jul 31, 2007
Completion: Mar 31, 2009
NCT00694109
An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-Hypercholesterolemia
Start: Apr 30, 2008
Completion: Sep 30, 2014
NCT00706849
Efficacy and Safety Study of ISIS 301012 (Mipomersen) as Add-on in Familial Hypercholesterolemic Patients With Coronary Artery Disease
Start: Jul 31, 2008
Completion: May 31, 2010
NCT00707746
Safety and Efficacy Study of ISIS 301012 (Mipomersen) Administration in High Risk Statin Intolerant Subjects
Start: Oct 31, 2008
Completion: Jan 31, 2011
NCT00770146
Safety and Efficacy of Mipomersen (ISIS 301012) As Add-on Therapy in High Risk Hypercholesterolemic Patients
Start: Nov 30, 2008
Completion: Oct 31, 2010
NCT00794664
Safety and Efficacy of Mipomersen in Patients With Severe Hypercholesterolemia on a Maximally Tolerated Lipid-Lowering Regimen and Who Are Not on Apheresis
Start: Jan 31, 2009
NCT01061814
A Study to Evaluate 3 Different Dosing Regimens of Mipomersen Administered Via Subcutaneous Injections to Healthy Volunteers
Phase: Phase 1
Start: Jan 31, 2010
Completion: Jun 30, 2010
NCT01090661
A Study to Evaluate the Effect of Mipomersen on Cardiac Repolarization Conducted in Healthy Subjects
Start: Mar 31, 2010
NCT01133366
A Study to Determine the Effects of Multiple Doses of Mipomersen (200 mg SC) on the Pharmacodynamics and Pharmacokinetics of Single-dose Warfarin
Start: May 31, 2010
Completion: Jul 31, 2010
NCT01299298
A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of Mipomersen in Japanese Healthy Volunteers
Start: Jan 31, 2011
Completion: Apr 30, 2011
NCT01414881
Study to Assess the Effects of Mipomersen on Lipid and Lipoprotein Metabolism in Healthy Subjects
Start: Sep 30, 2011
Completion: Nov 30, 2012
NCT01475825
A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol
Start: Dec 31, 2011
Completion: Dec 29, 2015