Synthetic oligonucleotides vaccines, adjuvants
Total Trials
30
As Lead Sponsor
25
As Collaborator
5
Total Enrollment
17,943
NCT00251394
Study of Dynavax's 1018 ISS, Following Rituxan in Patients With B-Cell Follicular Lymphoma
Phase: Phase 2
Role: Collaborator
Start: Jul 31, 2004
Completion: Jul 31, 2009
NCT00426712
Safety of HEPLISAV™ Hepatitis B Virus Vaccine in End-stage Kidney Failure Patients
Phase: Phase 1
Role: Lead Sponsor
Start: Jan 31, 2006
Completion: Mar 31, 2008
NCT00387738
Efficacy and Safety Study of TOLAMBA™ in Ragweed-Allergic Adults
Start: Apr 30, 2006
NCT00403052
A Study of 1018 Immunostimulatory Sequence (ISS) Administered With Irinotecan and Cetuximab to Treat Patients With Previously Treated Metastatic Colorectal Cancer
Start: Nov 30, 2006
Completion: Dec 31, 2007
NCT00435812
Safety and Efficacy of HEPLISAV™ Hepatitis B Virus Vaccine Compared With Engerix-B® Vaccine
Phase: Phase 3
Start: Dec 31, 2006
NCT00511095
Open-Label Study of the Safety and Immunogenicity of HEPLISAV™ Hepatitis B Virus Vaccine
Start: Jun 30, 2007
NCT00498212
A Safety and Efficacy Study of a Single or Double Dose of HEPLISAV™ Hepatitis B Vaccine in Adults With End-Stage Renal Disease
Start: Jul 31, 2007
Completion: Oct 31, 2008
NCT00537355
An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber
Start: Sep 30, 2007
Completion: May 31, 2008
NCT00599001
Safety, Pharmacokinetics, and Pharmacodynamics of SD-101 in Healthy Normal Males
Start: Jan 31, 2008
NCT00823862
Safety Study of SD-101 (a Novel C Type Toll-like Receptor 9 (TLR9) Agonist) for the Treatment of Chronic Hepatitis C Virus (HCV) Infection
Start: Oct 31, 2008
Completion: Feb 28, 2010
NCT00985426
Comparing Safety and Immunogenicity of HEPLISAV-B® to Engerix-B® in Chronic Kidney Disease (CKD) Patients
Start: Sep 30, 2009
Completion: Jan 31, 2012
NCT01023230
A Study to Assess DV-601 in Subjects With Chronic Hepatitis B
Completion: May 31, 2011
NCT01005407
Safety and Immunogenicity Study of the Hepatitis B Virus (HBV) Vaccine, HEPLISAV Compared to Engerix-B Vaccine
Start: Feb 28, 2010
NCT01195246
Safety and Immunogenicity of HEPLISAV™ a Hepatitis B Virus Vaccine in Adults on Hemodialysis
Start: Dec 31, 2010
Completion: Aug 31, 2012
NCT01282762
Long-Term Study on Safety and Immunogenicity of HEPLISAV™ and Engerix-B® in Adults With Chronic Kidney Disease
Phase: N/A
Completion: Aug 31, 2013
NCT01999699
A Study of the Immune Response to Heplisav in Healthy Older Adults
Start: Nov 30, 2013
Completion: Mar 31, 2015
NCT02117934
Safety and Immunogenicity Study of the Hepatitis B Vaccine, HEPLISAV™, Compared to Engerix-B® Vaccine
Start: Apr 30, 2014
Completion: Oct 31, 2015
NCT02266147
Study of SD-101 in Combination With Localized Low-dose Radiation in Patients With Untreated Low-grade B-cell Lymphoma
Phase: Phase 1/2
Start: Oct 31, 2014
Completion: Apr 30, 2017
NCT02521870
A Trial of Intratumoral Injections of SD-101 in Combination With Pembrolizumab in Patients With Metastatic Melanoma or Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Start: Sep 30, 2015
Completion: Apr 30, 2020
NCT03326752
Phase 1b DV281 With an Anti-PD-1 Inhibitor in NSCLC
Start: Sep 20, 2017
Completion: Sep 19, 2019
NCT03934736
HEPLISAV-B® in Adults With End-Stage Renal Disease (ESRD) Undergoing Hemodialysis
Start: Apr 22, 2019
Completion: Sep 15, 2021
NCT04050085
SD-101, Nivolumab, and Radiation Therapy in Treating Patients With Chemotherapy-Refractory Metastatic Pancreatic Cancer
Start: Aug 15, 2019
Completion: May 14, 2022
NCT04177355
Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults
Start: Jan 13, 2020
Completion: Nov 4, 2024
NCT04385524
Use of Dynavax Heplisav B in Healthcare Workers Previously Vaccinated With 3-dose Vaccine Who Failed to Demonstrate Seroprotection
Start: Jun 1, 2020
Completion: Feb 28, 2021
NCT04193189
B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B
Start: Dec 14, 2020
Completion: Aug 13, 2024
NCT03664648
DV2-HBV-27: Observational Pregnancy Registry
Start: Feb 21, 2021
Completion: Dec 31, 2024
NCT05245838
Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adult Volunteers
Start: Jan 10, 2022
Completion: Oct 20, 2022
NCT05506969
Trial of the Immunogenicity, Safety, and Tolerability of rF1V Vaccine With CpG 1018® Adjuvant Compared With rF1V Vaccine in Adults 18 to 55 Years of Age
Start: Aug 9, 2022
Completion: Apr 26, 2024
NCT06569823
Safety and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adults
Start: Jun 17, 2024
Completion: Sep 30, 2026
NCT07207408
Immunogenicity, Safety, and Tolerability of rF1V-1018 Vaccine in Adults 18 to 55 Years of Age
Start: Sep 11, 2025
Completion: Oct 16, 2026
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