Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults

PHASE1CompletedINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

January 13, 2020

Primary Completion Date

November 4, 2024

Study Completion Date

November 4, 2024

Conditions
HIV Infections
Interventions
BIOLOGICAL

BG505 SOSIP.664 gp140

Administered by IM injection

BIOLOGICAL

Placebo

Administered by IM injection

BIOLOGICAL

3M-052-AF

Administered by IM injection

BIOLOGICAL

CpG 1018

Administered by IM injection

BIOLOGICAL

GLA-LSQ

Administered by IM injection

BIOLOGICAL

Alum (Aluminum Hydroxide Suspension)

Administered by IM injection

BIOLOGICAL

Trimer 4571

Administered by IM injection

Trial Locations (10)

10032

Columbia P&S CRS, New York

10065

New York Blood Center CRS (Site 31801), New York

14642

University of Rochester Vaccines to Prevent HIV Infection CRS, Rochester

15213

University of Pittsburgh CRS, Pittsburgh

19104

Penn Prevention CRS, Philadelphia

30030

The Hope Clinic of the Emory Vaccine Center CRS, Decatur

35294

Alabama CRS, Birmingham

30308-2012

The Ponce de Leon Center CRS, Atlanta

02115-6110

Brigham and Women's Hospital Vaccine CRS (BWH VCRS), Boston

98109-1024

Seattle Vaccine and Prevention CRS, Seattle

Sponsors
All Listed Sponsors
collaborator

HIV Vaccine Trials Network

NETWORK

collaborator

International AIDS Vaccine Initiative

NETWORK

collaborator

Access to Advanced Health Institute (AAHI)

OTHER

collaborator

Dynavax Technologies Corporation

INDUSTRY

collaborator

Fred Hutchinson Cancer Center

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT04177355 - Evaluating the Safety and Immunogenicity of HIV-1 BG505 SOSIP.664 gp140 With TLR Agonist and/or Alum Adjuvants in Healthy, HIV-uninfected Adults | Biotech Hunter | Biotech Hunter