Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

November 1, 2025

Primary Completion Date

May 1, 2027

Study Completion Date

May 1, 2027

Conditions
CognitionBDNF
Interventions
DRUG

d-beta-hydroxybutrate

During the ketosis trial, participants will be given d-beta-hydroxybutrate mixed with sugar-free gatorade in a 1:1 ratio. This is to ensure the participant's electrolytes are high and to mask the bitter taste of d-beta-hydroxybutrate. The dosage per participant will be calculated 0.1816g/lb based on body weight to ensure participants remain in a state of ketosis for a minimum of 2 hours.

DRUG

Placebo

Participants will consume a placebo consisting of a pure electrolyte drink.

Trial Locations (1)

90089

University of Southern California, Los Angeles

All Listed Sponsors
lead

University of Southern California

OTHER