450
Participants
Start Date
November 30, 2025
Primary Completion Date
October 31, 2029
Study Completion Date
May 31, 2033
Vepugratinib
Administered orally
Placebo
Administered orally
EV
Administered by IV infusion
Pembrolizumab
Administered by IV infusion
National Taiwan University Cancer Center (NTUCC), Taipei
Chang Gung Medical Foundation-Linkou Branch, Taoyuan District
Taichung Veterans General Hospital, Taichung
National Cheng Kung University Hospital, Tainan City
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
Semmelweis Egyetem, Budapest
Országos Onkológiai Intézet, Budapest
Prince of Wales Hospital, Randwick
Macquarie University, Macquarie University
Herlev and Gentofte Hospital, Copenhagen
Austin Health, Heidelberg
Box Hill Hospital, Box Hill
Debreceni Egyetem Klinikai Kozpont, Debrecen
Mater Misericordiae Limited, Brisbane
Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyíregyháza
Næstved Sygehus, Næstved
Sir Charles Gairdner Hospital, Perth
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged
Aarhus Universitetshospital, Skejby, Aarhus
Aalborg Universitetshospital, Syd, Aalborg
National Taiwan University Hospital, Taipei
Icahn School of Medicine at Mount Sinai, New York
Fakultni nemocnice Kralovske Vinohrady, Prague
Memorial Sloan Kettering Cancer Center, New York
Weill Cornell Medical College, New York
Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin
National Cancer Center, Goyang-si
Taipei Veterans General Hospital, Taipei
Institut Paoli-Calmettes, Marseille
Seoul National University Bundang Hospital, Seongnam
Hospital Universitario Reina Sofia, Córdoba
Fakultni Thomayerova nemocnice, Prague
Centre François Baclesse, Caen
AHN Allegheny General Hospital, Pittsburgh
Helios Klinikum Bad Saarow, Bad Saarow
CHUS - Hospital Clinico Universitario, Santiago de Compostela
Institut Català d'Oncologia (ICO) - Girona, Girona
Universitätsmedizin Greifswald, Greifswald
Lancaster General Hospital - Ann B Barshinger Cancer Institute, Lancaster
Universitätsmedizin Rostock, Rostock
Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
Memorial Diyarbakır Hastanesi, Diyarbakır
Johns Hopkins Hospital, Baltimore
Gachon University Gil Medical Center, Namdong-gu
Trakya University, Edirne
USO - Virginia Oncology Associates, Norfolk
Universitätsklinikum Schleswig-Holstein, Lübeck
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep
Hospital La Princesa, Madrid
Hospital General Universitario Gregorio Marañon, Madrid
MD Anderson Cancer Center, Madrid
Hospital Universitario Ramón y Cajal, Madrid
Hospital Clinico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón
H.R.U Málaga - Hospital General, Málaga
CHRU de Brest, Brest
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carém -T, Nîmes
Complejo Hospitalario de Navarra, Pamplona
Oncopole Claudius Regaud, Toulouse
CHU de Bordeaux Hop St ANDRE, Bordeaux
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux
Evangelisches Krankenhaus Bielefeld - Johannesstift, Bielefeld
AdventHealth Celebration, Celebration
Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul
Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Istanbul
Chungnam national university hospital, Junggu
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria
Istituto Oncologico Veneto IRCCS, Padua
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir
Clearview Cancer Institute, Huntsville
Sarah Cannon Research Institute, Nashville
SCRI Oncology Partners, Nashville
Tennessee Oncology, Nashville
Vanderbilt University Medical Center, Nashville
Tennessee Oncology Chattanooga, Chattanooga
Hospital Universitario Marqués de Valdecilla, Santander
Universitaetsklinikum Duesseldorf, Düsseldorf
Hospital Universitario Virgen Del Rocio, Seville
Hospital Universitari Sant Joan de Reus, Reus
Universitaetsklinikum Essen, Essen
Hospital Arnau de Vilanova, Valencia
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne
Urologicum Duisburg Fachärztesozietät - Walsum, Duisburg
Universitätsklinikum Münster - Albert Schweitzer Campus, Münster
Karmanos Cancer Institute, Detroit
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo
Institut de Cancérologie de l'Ouest, Angers
Studienzentrum Bayenthal Urologische Partnerschaft Köln, Cologne
Johanniter-Krankenhaus, Bonn
Sakarya University School of Medicine, Adapazarı
InVO Institut für Versorgungsforschung in der Onkologie, Koblenz
Azienda Ospedaliera Universitaria Pisana, Pisa
Avera Cancer Institute- Research, Sioux Falls
Centre Oscar Lambret, Lille
Krankenhaus Nordwest GmbH, Frankfurt
Washington University, St Louis
NCT, Heidelberg
Centre Hospitalier Lyon Sud, Pierre-Bénite
Centre Leon Berard, Lyon Cedex08
Instituto Tumori Giovanni Paolo II, Bari
Mary Bird Perkins Cancer Center, Baton Rouge
Chi Mei Medical Center, Tainan City
Universitaetsklinikum Tuebingen, Tübingen
Studienpraxis Urologie, Nürtingen
Chi Mei Hospital - Liouying Branch, Tainan City
Parkland Health and Hospital System, Dallas
UT Southwestern Medical Center, Dallas
USO - Texas Oncology - Northeast Texas, Tyler
US Oncology Research Network, The Woodlands
World Research Link, Baytown
USO-Texas Oncology-Central/South Texas, Austin
Universitaetsklinikum Freiburg, Freiburg im Breisgau
Azienda Ospedaliera Universitaria Federico II, Napoli
AdventHealth Medical Group - Porter, Denver
Colorado West Healthcare System - Grand Valley Oncology, Grand Junction
Klinikum Rechts Der Isar Der Technischen Universität München, Munich
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist
The University of Arizona Cancer Center - North Campus, Tucson
Universitaetsklinikum Ulm, Ulm
Comprehensive Cancer Centers of Nevada, Las Vegas
TRIO-US (Translational Research in Oncology-US), Los Angeles
UCLA Hematology/Oncology - Santa Monica, Los Angeles
Klinikum Nürnberg Nord, Nuremberg
Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN), Torrance
Universitaetsklinikum Erlangen, Erlangen
UCSF Medical Center at Mission Bay, San Francisco
Gustave Roussy, Villejuif
Universitaetsklinikum Wuerzburg, Würzburg
Providence Portland Medical Center, Portland
Providence St. Vincent Medical Center, Portland
Kaiser Permanente Interstate Medical Office Central, Portland
Oregon Health and Science University, Portland
The First Hospital of Jilin University, Changchun
Peking University First Hospital, Beijing
Peking University Third Hospital, Beijing
Beijing Cancer hospital, Beijing
Beijing GoBroad Hospital, Beijing
Harbin Medical University Cancer Hospital, Harbin
Huashan Hospital, Fudan University, Shanghai
Shanghai Tenth People's Hospital, Shanghai
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing
The Second Hospital of Tianjin Medical University, Tianjin
Zhejiang Provincial People's Hospital, Hangzhou
Sir Run Run Shaw Hospital, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Ningbo First Hospital, Ningbo
The First Affiliated Hospital of Chongqing Medical University, Chongqing
Chongqing University Cancer Hospital, Chongqing
China Medical University Hospital, Taichung
Xiangya Hospital Central South University, Changsha
Hunan Cancer Hospital, Changsha
Tongji Hospital Tongji Medical,Science & Technology, Wuhan
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
Zhujiang Hospital, Guangzhou
Sun Yat-Sen University Cancer Centre, Guangzhou
Guangxi Medical University Affiliated Tumor Hospital, Nanning
West China Hospital, Sichuan University, Chengdu
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos
Centro Integrado de Oncologia de Curitiba, Curitiba
Massachusetts General Hospital, Boston
CPAM - Centro de Pesquisas da Amazônia, Belém
Oncocentro de Minas Gerais, Belo Horizonte
Hospital Mario Penna, Belo Horizonte
Hospital Tacchini, Bento Gonçalves
IOP Pesquisa, Curitiba
Centro Paraibano De Oncologia - Oncoclínicas, João Pessoa
Hospital de Cancer de Londrina, Londrina
Liga Norte Riograndense Contra o Câncer, Natal
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre
Hospital São Lucas da PUCRS, Porto Alegre
Hospital Nossa Senhora da Conceição, Porto Alegre
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro
Nucleo de Oncologia da Bahia, Salvador
Clinica Amo - Rio Vermelho, Salvador
Instituto de Oncologia Saint Gallen, Santa Cruz do Sul
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul
Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo
Hospital BP, São Paulo
Hospital Alemao Oswaldo Cruz, São Paulo
Centro Paulista de Oncologia Clínica, São Paulo
IBCC - Núcleo de Pesquisa e Ensino, São Paulo
Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec
BC Cancer Vancouver, Vancouver
Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai
Masarykuv onkologicky ustav, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice Motol, Prague
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden, Dresden
Fondazione Policlinico Universitario Agostino Gemelli, Roma
Istituto Nazionale Tumori Regina Elena, Rome
National Cancer Center Hospital, Chūōku
Hirosaki University Hospital, Hirosaki
Kanazawa University Hospital, Kanazawa
National Cancer Center Hospital East, Kashiwa
St. Marianna University Hospital, Kawasaki
Kagawa University Hospital, Kita-ku
Kobe City Medical Center General Hospital, Kobe
The Cancer Institute Hospital of JFCR, Kōtoku
National Hospital Organization Shikoku Cancer Center, Matsuyama
Aichi Cancer Center Hospital, Nagoya
Osaka International Cancer Institute, Osaka
Gunma Prefectural Cancer Center, Otashi
Hokkaido University Hospital, Sapporo
Tohoku University Hospital, Sendai
Iwate Medical University Hospital, Shiwa-gun Yahaba-cho
Tokushima University Hospital, Tokushima
Tsukuba University Hospital, Tsukuba
Amsterdam UMC, locatie VUmc, Amsterdam
Amphia Ziekenhuis, locatie Breda Molengracht, Breda
Radboudumc, Nijmegen
Erasmus Medisch Centrum, Rotterdam
IN VIVO, Bydgoszcz
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie, Koszalin
Pratia MCM Krakow, Krakow
AIDPORT Sp. z o.o., Skórzewo
GYNCENTRUM Szpital, Sosnowiec
Luxmed Onkologia sp. z o. o., Warsaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw
WSD MEDI, Warsaw
Medical Concierge Centrum Medyczne, Warsaw
Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ, Warsaw
Wojskowy Instytut Medyczny Państwowy Instytut Badawczy, Warsaw
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul
Hospital Infanta Cristina, Badajoz
Institut Català d'Oncologia (ICO) - Badalona, Badalona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clínic de Barcelona, Barcelona
Hospital de la Santa Creu i Sant Pau, Barcelona
Hospital General Universitario de Elche, Elche
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet
Adana Medical Park Seyhan Hastanesi, Adana
Ankara University Health Practice and Research Hospitals, Ankara
Ankara Bilkent Şehir Hastanesi, Ankara
Antalya Egitim ve Arastırma Hastanesi, Antalya
Huddersfield Royal Infirmary, Huddersfield
St Bartholomew's Hospital, London
University College London Hospital, London
Royal Marsden Hospital (Sutton), London
Royal Marsden Hospital (Chelsea), London
The Christie NHS Foundation Trust, Manchester
Weston Park Hospital, Sheffield
Eli Lilly and Company
INDUSTRY