A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

October 31, 2029

Study Completion Date

May 31, 2033

Conditions
Carcinoma, Transitional CellUrinary Bladder NeoplasmsNeoplasm Metastasis
Interventions
DRUG

Vepugratinib

Administered orally

OTHER

Placebo

Administered orally

DRUG

EV

Administered by IV infusion

DRUG

Pembrolizumab

Administered by IV infusion

Trial Locations (254)

106

National Taiwan University Cancer Center (NTUCC), Taipei

333

Chang Gung Medical Foundation-Linkou Branch, Taoyuan District

407

Taichung Veterans General Hospital, Taichung

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1082

Semmelweis Egyetem, Budapest

1122

Országos Onkológiai Intézet, Budapest

2031

Prince of Wales Hospital, Randwick

2109

Macquarie University, Macquarie University

2730

Herlev and Gentofte Hospital, Copenhagen

3084

Austin Health, Heidelberg

3128

Box Hill Hospital, Box Hill

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4101

Mater Misericordiae Limited, Brisbane

4400

Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyíregyháza

4700

Næstved Sygehus, Næstved

6009

Sir Charles Gairdner Hospital, Perth

6725

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged

8200

Aarhus Universitetshospital, Skejby, Aarhus

9000

Aalborg Universitetshospital, Syd, Aalborg

10002

National Taiwan University Hospital, Taipei

10029

Icahn School of Medicine at Mount Sinai, New York

10034

Fakultni nemocnice Kralovske Vinohrady, Prague

10065

Memorial Sloan Kettering Cancer Center, New York

Weill Cornell Medical College, New York

10117

Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin

10408

National Cancer Center, Goyang-si

11217

Taipei Veterans General Hospital, Taipei

13273

Institut Paoli-Calmettes, Marseille

13620

Seoul National University Bundang Hospital, Seongnam

14004

Hospital Universitario Reina Sofia, Córdoba

14059

Fakultni Thomayerova nemocnice, Prague

14076

Centre François Baclesse, Caen

15212

AHN Allegheny General Hospital, Pittsburgh

15526

Helios Klinikum Bad Saarow, Bad Saarow

15706

CHUS - Hospital Clinico Universitario, Santiago de Compostela

17007

Institut Català d'Oncologia (ICO) - Girona, Girona

17489

Universitätsmedizin Greifswald, Greifswald

17601

Lancaster General Hospital - Ann B Barshinger Cancer Institute, Lancaster

18057

Universitätsmedizin Rostock, Rostock

20132

Ospedale San Raffaele, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

21070

Memorial Diyarbakır Hastanesi, Diyarbakır

21287

Johns Hopkins Hospital, Baltimore

21565

Gachon University Gil Medical Center, Namdong-gu

22030

Trakya University, Edirne

23502

USO - Virginia Oncology Associates, Norfolk

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

27310

Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep

28006

Hospital La Princesa, Madrid

28009

Hospital General Universitario Gregorio Marañon, Madrid

28033

MD Anderson Cancer Center, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28223

Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón

29011

H.R.U Málaga - Hospital General, Málaga

29609

CHRU de Brest, Brest

30029

Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carém -T, Nîmes

31009

Complejo Hospitalario de Navarra, Pamplona

31059

Oncopole Claudius Regaud, Toulouse

33075

CHU de Bordeaux Hop St ANDRE, Bordeaux

33076

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux

33611

Evangelisches Krankenhaus Bielefeld - Johannesstift, Bielefeld

34747

AdventHealth Celebration, Celebration

34890

Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul

34899

Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Istanbul

35015

Chungnam national university hospital, Junggu

35016

Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria

35128

Istituto Oncologico Veneto IRCCS, Padua

35360

zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir

35805

Clearview Cancer Institute, Huntsville

37203

Sarah Cannon Research Institute, Nashville

SCRI Oncology Partners, Nashville

Tennessee Oncology, Nashville

37232

Vanderbilt University Medical Center, Nashville

37404

Tennessee Oncology Chattanooga, Chattanooga

39008

Hospital Universitario Marqués de Valdecilla, Santander

40225

Universitaetsklinikum Duesseldorf, Düsseldorf

41013

Hospital Universitario Virgen Del Rocio, Seville

43204

Hospital Universitari Sant Joan de Reus, Reus

45122

Universitaetsklinikum Essen, Essen

46015

Hospital Arnau de Vilanova, Valencia

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

46845

Parkview Research Center at Parkview Regional Medical Center, Fort Wayne

47179

Urologicum Duisburg Fachärztesozietät - Walsum, Duisburg

48149

Universitätsklinikum Münster - Albert Schweitzer Campus, Münster

48201

Karmanos Cancer Institute, Detroit

48903

OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo

49055

Institut de Cancérologie de l'Ouest, Angers

50968

Studienzentrum Bayenthal Urologische Partnerschaft Köln, Cologne

53113

Johanniter-Krankenhaus, Bonn

54100

Sakarya University School of Medicine, Adapazarı

56068

InVO Institut für Versorgungsforschung in der Onkologie, Koblenz

56126

Azienda Ospedaliera Universitaria Pisana, Pisa

57105

Avera Cancer Institute- Research, Sioux Falls

59020

Centre Oscar Lambret, Lille

60488

Krankenhaus Nordwest GmbH, Frankfurt

63108

Washington University, St Louis

69120

NCT, Heidelberg

69310

Centre Hospitalier Lyon Sud, Pierre-Bénite

69373

Centre Leon Berard, Lyon Cedex08

70124

Instituto Tumori Giovanni Paolo II, Bari

70809

Mary Bird Perkins Cancer Center, Baton Rouge

71004

Chi Mei Medical Center, Tainan City

72076

Universitaetsklinikum Tuebingen, Tübingen

72622

Studienpraxis Urologie, Nürtingen

73657

Chi Mei Hospital - Liouying Branch, Tainan City

75235

Parkland Health and Hospital System, Dallas

75390

UT Southwestern Medical Center, Dallas

75702

USO - Texas Oncology - Northeast Texas, Tyler

77380

US Oncology Research Network, The Woodlands

77521

World Research Link, Baytown

78731

USO-Texas Oncology-Central/South Texas, Austin

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

80131

Azienda Ospedaliera Universitaria Federico II, Napoli

80210

AdventHealth Medical Group - Porter, Denver

81505

Colorado West Healthcare System - Grand Valley Oncology, Grand Junction

81675

Klinikum Rechts Der Isar Der Technischen Universität München, Munich

83301

Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist

85719

The University of Arizona Cancer Center - North Campus, Tucson

89081

Universitaetsklinikum Ulm, Ulm

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

90024

TRIO-US (Translational Research in Oncology-US), Los Angeles

90404

UCLA Hematology/Oncology - Santa Monica, Los Angeles

90419

Klinikum Nürnberg Nord, Nuremberg

90505

Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN), Torrance

91054

Universitaetsklinikum Erlangen, Erlangen

94158

UCSF Medical Center at Mission Bay, San Francisco

94800

Gustave Roussy, Villejuif

97080

Universitaetsklinikum Wuerzburg, Würzburg

97213

Providence Portland Medical Center, Portland

97225

Providence St. Vincent Medical Center, Portland

97227

Kaiser Permanente Interstate Medical Office Central, Portland

97239

Oregon Health and Science University, Portland

100012

The First Hospital of Jilin University, Changchun

100034

Peking University First Hospital, Beijing

100091

Peking University Third Hospital, Beijing

100142

Beijing Cancer hospital, Beijing

102200

Beijing GoBroad Hospital, Beijing

150081

Harbin Medical University Cancer Hospital, Harbin

200040

Huashan Hospital, Fudan University, Shanghai

200072

Shanghai Tenth People's Hospital, Shanghai

210000

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing

300211

The Second Hospital of Tianjin Medical University, Tianjin

310014

Zhejiang Provincial People's Hospital, Hangzhou

310016

Sir Run Run Shaw Hospital, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

315010

Ningbo First Hospital, Ningbo

400016

The First Affiliated Hospital of Chongqing Medical University, Chongqing

400030

Chongqing University Cancer Hospital, Chongqing

404332

China Medical University Hospital, Taichung

410008

Xiangya Hospital Central South University, Changsha

410013

Hunan Cancer Hospital, Changsha

430030

Tongji Hospital Tongji Medical,Science & Technology, Wuhan

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

510280

Zhujiang Hospital, Guangzhou

511400

Sun Yat-Sen University Cancer Centre, Guangzhou

530200

Guangxi Medical University Affiliated Tumor Hospital, Nanning

610066

West China Hospital, Sichuan University, Chengdu

14784400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

80810050

Centro Integrado de Oncologia de Curitiba, Curitiba

02114

Massachusetts General Hospital, Boston

66063-495

CPAM - Centro de Pesquisas da Amazônia, Belém

30180-060

Oncocentro de Minas Gerais, Belo Horizonte

30380-472

Hospital Mario Penna, Belo Horizonte

95700-084

Hospital Tacchini, Bento Gonçalves

82305-100

IOP Pesquisa, Curitiba

58030-080

Centro Paraibano De Oncologia - Oncoclínicas, João Pessoa

86015-520

Hospital de Cancer de Londrina, Londrina

59062-000

Liga Norte Riograndense Contra o Câncer, Natal

90110-270

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre

90610-000

Hospital São Lucas da PUCRS, Porto Alegre

91350-200

Hospital Nossa Senhora da Conceição, Porto Alegre

20231-050

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro

22271-110

Instituto D'Or Pesquisa e Ensino, Rio de Janeiro

40170-110

Nucleo de Oncologia da Bahia, Salvador

41950-640

Clinica Amo - Rio Vermelho, Salvador

96830-180

Instituto de Oncologia Saint Gallen, Santa Cruz do Sul

09541-270

Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul

01209-000

Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo

01246-000

Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo

01321-001

Hospital BP, São Paulo

01327-001

Hospital Alemao Oswaldo Cruz, São Paulo

01452-000

Centro Paulista de Oncologia Clínica, São Paulo

04014-002

IBCC - Núcleo de Pesquisa e Ensino, São Paulo

L8V5C2

Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton

G1J 1Z4

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec

V5Z 4E6

BC Cancer Vancouver, Vancouver

Unknown

Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai

656 53

Masarykuv onkologicky ustav, Brno

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

779 00

Fakultni nemocnice Olomouc, Olomouc

150 06

Fakultni nemocnice Motol, Prague

01307

Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden, Dresden

00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

00144

Istituto Nazionale Tumori Regina Elena, Rome

104-0045

National Cancer Center Hospital, Chūōku

036-8563

Hirosaki University Hospital, Hirosaki

920-8641

Kanazawa University Hospital, Kanazawa

277-8577

National Cancer Center Hospital East, Kashiwa

216-8511

St. Marianna University Hospital, Kawasaki

761-0701

Kagawa University Hospital, Kita-ku

650-0047

Kobe City Medical Center General Hospital, Kobe

135-8550

The Cancer Institute Hospital of JFCR, Kōtoku

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

464-8681

Aichi Cancer Center Hospital, Nagoya

541-8567

Osaka International Cancer Institute, Osaka

373-8550

Gunma Prefectural Cancer Center, Otashi

060-8648

Hokkaido University Hospital, Sapporo

980-8574

Tohoku University Hospital, Sendai

028-3695

Iwate Medical University Hospital, Shiwa-gun Yahaba-cho

770-8503

Tokushima University Hospital, Tokushima

305-8576

Tsukuba University Hospital, Tsukuba

1081 HV

Amsterdam UMC, locatie VUmc, Amsterdam

4818 CK

Amphia Ziekenhuis, locatie Breda Molengracht, Breda

6525 GA

Radboudumc, Nijmegen

3015 GD

Erasmus Medisch Centrum, Rotterdam

85-048

IN VIVO, Bydgoszcz

75-581

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie, Koszalin

30-727

Pratia MCM Krakow, Krakow

60-185

AIDPORT Sp. z o.o., Skórzewo

41-208

GYNCENTRUM Szpital, Sosnowiec

01-748

Luxmed Onkologia sp. z o. o., Warsaw

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw

02-786

WSD MEDI, Warsaw

02-798

Medical Concierge Centrum Medyczne, Warsaw

04-073

Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ, Warsaw

04-141

Wojskowy Instytut Medyczny Państwowy Instytut Badawczy, Warsaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul

06006

Hospital Infanta Cristina, Badajoz

08916

Institut Català d'Oncologia (ICO) - Badalona, Badalona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

03202

Hospital General Universitario de Elche, Elche

08907

Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet

01140

Adana Medical Park Seyhan Hastanesi, Adana

06100

Ankara University Health Practice and Research Hospitals, Ankara

06800

Ankara Bilkent Şehir Hastanesi, Ankara

07100

Antalya Egitim ve Arastırma Hastanesi, Antalya

HD3 3EA

Huddersfield Royal Infirmary, Huddersfield

EC1A 7BE

St Bartholomew's Hospital, London

NW1 2PG

University College London Hospital, London

SM2 5PT

Royal Marsden Hospital (Sutton), London

SW3 6JJ

Royal Marsden Hospital (Chelsea), London

M20 4BX

The Christie NHS Foundation Trust, Manchester

S10 2SJ

Weston Park Hospital, Sheffield

All Listed Sponsors
lead

Eli Lilly and Company

INDUSTRY