140
Participants
Start Date
September 15, 2025
Primary Completion Date
September 30, 2030
Study Completion Date
September 30, 2035
Pressure pain thresholds (measured in kilopascal)
Pressure will be increased continually and participants will be instructed to press a button the first moment they feel pain from the pressure stimulus. The first threshold measurement will be used as a familiarization. The average threshold is calculated from three measurements. Higher value indicates lower experimental pain sensitivity
Cold pain tolerance (duration in seconds)
Cold pain tolerance will be assessed by having participants immerse their hand or foot in a cold (4-12°C) water bath. Tolerance will be defined by the time of hand withdrawal. Pain ratings of cold pain intensity might be obtained periodically, and both pain intensity and pain unpleasantness will be recorded upon hand/foot withdrawal. Higher value indicates lower experimental pain sensitivity
RECRUITING
Washington University School of Medicine, St Louis
Washington University School of Medicine
OTHER