Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

PHASE4RecruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

November 1, 2025

Primary Completion Date

May 1, 2027

Study Completion Date

October 1, 2027

Conditions
Osteoarthritis HandOsteoarthritis Wrist
Interventions
DRUG

Corticosteroid injection (CSI)

"A maximum of 3 joints will be treated with standard a standard combination of methylprednisolone and lidocaine:~* 1st Carpometacarpal (CMC) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\*~* Radiocarpal (RC) joint - 40 mg methylprednisolone/1 mL 1% lidocaine\*~* Scaphotrapeziotrapezoidal (STT) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine\*~* Metacarpophalangeal (MCP) joint - 20 mg methylprednisolone/0.5 mL 1% lidocaine~* Interphalangeal (IP) joint - 10 mg methylprednisolone/0.25 mL 1% lidocaine"

RADIATION

Low-dose radiotherapy (LDRT)

"Subjects will be treated with low-dose radiotherapy of 300cGy in 6 fractions, 2-3 times per week on non-consecutive days.~Non-responders to the initial LDRT treatment will receive a second treatment course of 300cGy in 6 fractions to be given 2-3 times per week on non-consecutive days."

Trial Locations (1)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER