NCT07216690View on ClinicalTrials.gov

Pregnenolone as a Treatment for Cannabis Intoxication

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

December 1, 2025

Primary Completion Date

January 1, 2028

Study Completion Date

January 1, 2029

Conditions
Cannabis Intoxication
Interventions
DRUG

Cannabis

Cannabis brownie, 25mg THC

DRUG

Pregnenolone 250 mg

Pregnenolone, low dose, one 250mg pregnenolone capsule and one 0 mg pregnenolone capsule

DRUG

Pregnenolone 500 mg

Pregnenolone, high dose, two 250 mg pregnenolone capsules

DRUG

Placebo

Placebo capsule, 0mg

DRUG

Placebo brownie

Placebo brownie, 0mg THC

Trial Locations (1)

21224

Johns Hopkins University School of Medicine, Behavioral Pharmacology Research Unit, Baltimore

All Listed Sponsors
collaborator

National Institute on Drug Abuse (NIDA)

NIH

lead

Johns Hopkins University

OTHER