NCT07213934View on ClinicalTrials.gov

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

December 31, 2025

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2031

Conditions
Head and Neck CancerRecurrent Head and Neck Squamous Cell Carcinoma
Interventions
RADIATION

Proton therapy

Proton therapy is a type of radiation therapy that uses protons rather than x-rays. It painlessly delivers radiation to treat some types of cancer.

DRUG

Pembrolizumab

PDL-1 immunotherapy drug

Trial Locations (1)

45219

University of Cincinnati Medical Center, Cincinnati

All Listed Sponsors
lead

University of Cincinnati

OTHER