Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders

RecruitingOBSERVATIONAL
Enrollment

140

Participants

Timeline

Start Date

February 15, 2022

Primary Completion Date

March 18, 2026

Study Completion Date

September 18, 2026

Conditions
Neurocognitive DisordersAlzheimer's Disease
Interventions
DIAGNOSTIC_TEST

Assessment of carotid wall viscosity in patients with vascular dementia

Carotid wall viscosity will be assessed by simultaneous and continuous measurement by 2 operators of local pressure and diameter at the level of the right and left carotids by coupling echotracking (Vevo 3100®) with applanation tonometry (Millar®). 3 successive measurements will be carried out. These measurements will establish the diameter-pressure relationship and its analysis will allow the calculation of wall viscosity by measuring the area under the curve of this relationship during the cardiac cycle.

DIAGNOSTIC_TEST

Assessment of carotid wall viscosity in patients with Alzheimer's disease

Carotid wall viscosity will be assessed by simultaneous and continuous measurement by 2 operators of local pressure and diameter at the level of the right and left carotids by coupling echotracking (Vevo 3100®) with applanation tonometry (Millar®). 3 successive measurements will be carried out. These measurements will establish the diameter-pressure relationship and its analysis will allow the calculation of wall viscosity by measuring the area under the curve of this relationship during the cardiac cycle.

DIAGNOSTIC_TEST

Assessment of carotid wall viscosity in patients not presenting dementia.

Carotid wall viscosity will be assessed by simultaneous and continuous measurement by 2 operators of local pressure and diameter at the level of the right and left carotids by coupling echotracking (Vevo 3100®) with applanation tonometry (Millar®). 3 successive measurements will be carried out. These measurements will establish the diameter-pressure relationship and its analysis will allow the calculation of wall viscosity by measuring the area under the curve of this relationship during the cardiac cycle.

Trial Locations (1)

76031

RECRUITING

University Rouen Hospital, Rouen

All Listed Sponsors
lead

University Hospital, Rouen

OTHER