15
Participants
Start Date
May 20, 2025
Primary Completion Date
May 31, 2026
Study Completion Date
May 31, 2026
Propofol - Emergence-from-LOR Protocol
Intravenous propofol infusion that meets the criteria: (1) maintenance of spontaneous ventilation, (2) sedation level corresponding to a Patient State Index (PSI) no lower than 25; and (3) loss of responsiveness (LOR) defined by the Richmond Agitation Sedation Scale (RASS) = -5 \[unarousable\]. Anesthesia is then maintained at that level for 30 minutes, followed by spontaneous emergence.
Propofol - Light Sedation Protocol
Intravenous propofol infusion titrated stepwise to reach a state where participants are sedated but have behavioral responsiveness. Sedation is maintained at this level for 30 minutes.
Stanford University, Stanford
Tiny Blue Dot Foundation
OTHER
Stanford University
OTHER