Induction of Dreaming With EEG and Anesthesia in Healthy Adults

PHASE1Enrolling by invitationINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

May 20, 2025

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions
Healthy Volunteers
Interventions
DRUG

Propofol - Emergence-from-LOR Protocol

Intravenous propofol infusion that meets the criteria: (1) maintenance of spontaneous ventilation, (2) sedation level corresponding to a Patient State Index (PSI) no lower than 25; and (3) loss of responsiveness (LOR) defined by the Richmond Agitation Sedation Scale (RASS) = -5 \[unarousable\]. Anesthesia is then maintained at that level for 30 minutes, followed by spontaneous emergence.

DRUG

Propofol - Light Sedation Protocol

Intravenous propofol infusion titrated stepwise to reach a state where participants are sedated but have behavioral responsiveness. Sedation is maintained at this level for 30 minutes.

Trial Locations (1)

94305

Stanford University, Stanford

All Listed Sponsors
collaborator

Tiny Blue Dot Foundation

OTHER

lead

Stanford University

OTHER