Relmacabtagene Autoleucel Combined With Autologous Hematopoietic Stem Cell Transplantation, Orelabrutinib, and Sintilimab for Primary Central Nervous System Lymphoma

NANot yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

October 7, 2025

Primary Completion Date

October 1, 2029

Study Completion Date

October 1, 2029

Conditions
Primary Central Nervous System Lymphoma (PCNSL)
Interventions
DRUG

Relmacabtagene autoleucel and transplantation

This study enrolled patients with primary central nervous system lymphoma, from whom mononuclear cells and hematopoietic stem cells were collected. Participants receive infusions of hematopoietic stem cells and CAR-T cells, followed by maintenance therapy with orelabrutinib and sintilimab starting on day 15 post-transplantation, for a median duration of up to 6 months and 1 year, respectively.

All Listed Sponsors
lead

Zhengzhou University

OTHER

NCT07198464 - Relmacabtagene Autoleucel Combined With Autologous Hematopoietic Stem Cell Transplantation, Orelabrutinib, and Sintilimab for Primary Central Nervous System Lymphoma | Biotech Hunter | Biotech Hunter