Development of a Novel Multidimensional Therapeutic Intervention Protocol for MCI

NANot yet recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

November 1, 2026

Study Completion Date

December 1, 2026

Conditions
MCI-AD, Early Stage Alzheimer's Disease
Interventions
BEHAVIORAL

Olfactory stimulation

"Olfactory stimulation were set as follows:~Essential oil types: yuzu, lavender, lemon, and mint. Concentration: 158 μL of essential oil + 50 mL of water. The mixed solution was poured into the test tubes of the olfactory instrument, ensuring that the liquid levels of the four solutions were kept at the same height. Each scent was released for 30 seconds, followed by a 10-second air interval, with each cycle lasting 20 minutes."

BIOLOGICAL

Temporal Interference,TI

"During stimulation, the parameters were set as follows:~Δf=40Hz (2000Hz vs. 2040Hz) 2mA Stimulation duration: 20min We fixed the stimulation protocol and used a standard head to simulate stimulation of the entorhinal region."

COMBINATION_PRODUCT

Olfactory-TI Stimulation

"During stimulation, the parameters were set as follows:~Δf=40Hz (2000Hz vs. 2040Hz) 2mA Stimulation duration: 20min We fixed the stimulation protocol and used a standard head to simulate stimulation of the entorhinal region.~Olfactory stimulation were set as follows:~Essential oil types: yuzu, lavender, lemon, and mint. Concentration: 158 μL of essential oil + 50 mL of water. The mixed solution was poured into the test tubes of the olfactory instrument, ensuring that the liquid levels of the four solutions were kept at the same height. Each scent was released for 30 seconds, followed by a 10-second air interval, with each cycle lasting 20 minutes."

COMBINATION_PRODUCT

Sham Control

"During stimulation, the parameters were set as follows:~Δf=0Hz (2000Hz vs. 2000Hz) 2mA Stimulation duration: 20min.~Olfactory stimulation were set as follows:~Essential oil types: air. lasting 20 minutes."

All Listed Sponsors
collaborator

Shanghai Mental Health Center

OTHER

lead

Yuan Shen

OTHER

NCT07196592 - Development of a Novel Multidimensional Therapeutic Intervention Protocol for MCI | Biotech Hunter | Biotech Hunter