Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

December 5, 2025

Primary Completion Date

February 26, 2032

Study Completion Date

September 2, 2036

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Zongertinib

Zongertinib

DRUG

Pembrolizumab

Pembrolizumab

DRUG

Atezolizumab

Atezolizumab

DRUG

Durvalumab

Durvalumab

DRUG

Nivolumab

Nivolumab

Trial Locations (159)

114

Tri-Service General Hospital, Taipei

333

Chang Gung Memorial Hospital Linkou, Taoyuan

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

1185

Centro de Investigaciones Médicas y Desarrollo LC S.R.L. (LC Investigación), CABA

1210

Clinic Floridsdorf, Vienna

1426

Centro Oncologico Korben, CABA

1430

Clinica Adventista Belgrano, CABA

2650

Edegem - UNIV UZ Antwerpen, Edegem

3000

UZ Leuven, Leuven

4000

Centre Hospitalier Universitaire de Liège, Liège

Sjællands Universitetshospital, Roskilde

9006

Hospital Universitario De Burgos, Burgos

10016

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

10043

AOU San Luigi Gonzaga, Orbassano (TO)

10048

National Taiwan University Hospital, Taipei

10065

Memorial Sloan-Kettering Cancer Center, New York

10408

National Cancer Center, Goyang

11217

Taipei Veterans General Hospital, Taipei

11407

Hospital Jerez de la Frontera, Jerez de la Frontera

11526

Henry Dunant Hospital, Athens, Athens

11527

"Chest Hospital of Athens Sotiria", Athens

11796

National Cancer Institute, Cairo University, Cairo

12462

University General Hospital Attikon, Athens

13620

Seoul National University Bundang Hospital, Seongnam

14210

Centro de Infusion Profesional Integral (CIPI), Mexico City

16247

The Catholic University of Korea, St.Vincent's Hospital, Suwon

16499

Ajou University Hospital, Suwon

20037

George Washington University Cancer Center, Washington D.C.

20089

Istituto Clinico Humanitas, Rozzano (MI)

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

22031

Virginia Cancer Specialists, PC, Fairfax

22927

LungenClinic Grosshansdorf GmbH, Großhansdorf

26121

Pius-Hospital, Oldenburg, Oldenburg

28034

Hospital Universitario Ramon Y Cajal, Madrid

28040

Fundación Jiménez Díaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Puerta de Hierro, Madrid

29010

Hospital Virgen de la Victoria, Málaga

30052

Tianjin Medical University General Hospital, Tianjin

30060

Northwest Georgia Oncology Centers, Marietta

30318

Piedmont Cancer Institute, Atlanta

31008

Complejo Hospitalario de Navarra, Pamplona

31059

HOP Larrey, Toulouse

32763

Mid Florida Hematology and Oncology Center, Orange City

35033

HOP Pontchaillou, Rennes

37126

Azienda Ospedaliera Universitaria Integrata Verona, Verona

40447

China Medical University Hospital, Taichung

41013

Hospital Virgen del Rocío, Seville

43204

Salut Sant Joan de Reus, Reus

44093

HOP Nord Laennec, Nantes

44281

Meir Medical Center, Kfar Saba

45640

Centro Oncologico Internacional, Jalisco

46010

Hospital Clínico de Valencia, Valencia

50937

Universitätsklinikum Köln (AöR), Cologne

60611

Northwestern University, Chicago

60612

University of Illinois Hospital and Health Sciences System, Chicago

65929

Varisano LungenZentrum (VLZ), Frankfurt

66278

Centro Medico Zambrano Hellion, Monterrey

67200

Centre Régional de Lutte Contre le Cancer Paul Stauss, Strasbourg

69126

Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg

69677

HOP Louis Pradel, Bron

70124

Istituto Tumori Giovanni Paolo II, Bari

73730

Klinikum Esslingen, Esslingen am Neckar

79602

Hendrick Health, Abilene

80131

Istituto Nazionale IRCCS Tumori Fondazione Pascale, Napoli

82131

Asklepios Fachkliniken München-Gauting, Gauting

83706

Saint Alphonsus Regional Medical Center - Boise, Boise

84405

Community Cancer Trials of Utah, Ogden

89511

Cancer Care Specialists, Reno

90404

University of California Los Angeles, Santa Monica

93720

Premier Cancer Care, Fresno

94589

Northern California Kaiser Permanente, Vallejo

94805

INS Gustave Roussy, Villejuif

95045

Humanitas Istituto Clinico Catanese S.p.A., Misterbianco (CT)

97078

Universitätsklinikum Würzburg AÖR, Würzburg

97213

Providence Cancer Institute, Portland

100029

China-Japan Friendship Hospital, Beijing

130000

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

215006

The First Affiliated Hospital of Soochow University, Suzhou

221009

Affiliated Hospital, Xuzhou Medical college, Xuzhou

225001

Northern Jiangsu People's Hospital, Yangzhou

250117

Shandong Cancer Hospital, Jinan

276034

Linyi Cancer Hospital, Linyi

300060

Tianjin Cancer Hospital, Tianjin

310003

The First Affiliated Hospital, Zhejiang University, Hangzhou

317099

Taizhou Hospital of Zhejiang Province, Taizhou

330006

The First Affiliated Hospital of Nanchang University, Nanchang

407062

Polaris Medical S.A., Suceagu/ Cluj Napoca

430022

Wuhan Union Hospital, Wuhan

610041

Sichuan Cancer Hospital, Chengdu

West China Hospital of Sichuan University, Chengdu

650118

Yunnan Provincial Tumor Hospital, Kunming

905900

Ovidius Clinical Hospital S.R.L, Ovidiu

3109601

Rambam Health Care Campus, Haifa

5262000

Sheba Medical Center, Ramat Gan

6093246

Sourasky Medical Center, Tel Aviv

8420383

Bradford Hill- Centro de Investigación Clínica, Recoleta

9103102

Shaare Zedek Medical Center, Jerusalem 91031, Jerusalem

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth-Hitchcock Medical Center, Lebanon

1280AEB

Hospital Britanico de Buenos Aires, CABA

C1426ANZ

Instituto Medico Especializado Alexander Fleming, Capital Federal

14784-400

Hospital de Amor, Barretos

57020-360

NewData Clinical Research - Maceió, Maceió

59020-400

Centro de Pesquisa Oncology Natal, Natal

90110-270

Centro Gaúcho Integrado de Oncologia, Hematologia, Ensino e Pesquisa, Porto Alegre

09060-650

CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia, Santo André

01246-000

ICESP - Instituto do Cancer do Estado de Sao Paulo, São Paulo

01509-010

A.C. Camargo, São Paulo

M5G 2M9

Princess Margaret Cancer Centre, Toronto

Unknown

Centro de Estudios Clinicos SAGA, Providencia

Hebei Provincial Tumor Hospital, Shijiazhuang

Shefaa El Orman Oncology Hospital, Luxor

Queen Mary Hospital, Hong Kong

Sağlık Bilimleri Üniversitesi Gülhane Eğitim ve Araştırma Hastanesi, Ankara

00144

Istituti Fisioterapici Ospitalieri, Roma

464-8681

Aichi Cancer Center Hospital, Aichi, Nagoya

470-1192

Fujita Health University Hospital, Aichi, Toyoake

277-8577

National Cancer Center Hospital East, Chiba, Kashiwa

812-8582

Kyushu University Hospital, Fukuoka, Fukuoka

807-8556

Hospital of the University of Occupational and Environmental Health, Fukuoka, Kitakyushu

734-8551

Hiroshima University Hospital, Hiroshima, Hiroshima

003-0804

Hokkaido Cancer Center, Hokkaido, Sapporo

252-0375

Kitasato University Hospital, Kanagawa, Sagamihara

241-8515

Kanagawa Cancer Center, Kanagawa, Yokohama

981-0914

Sendai Kousei Hospital, Miyagi, Sendai

951-8566

Niigata Cancer Center Hospital, Niigata, Niigata

700-8558

Okayama University Hospital, Okayama, Okayama

573-1191

Kansai Medical University Hospital, Osaka, Hirakata

589-8511

Kindai University Hospital, Osaka, Osakasayama

541-8567

Osaka International Cancer Institute, Osaka, Osaka

591-8555

National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Sakai

350-1298

Saitama Medical University International Medical Center, Saitama, Hidaka

362-0806

Saitama Cancer Center, Saitama, Kitaadachi-gun

411-8777

Shizuoka Cancer Center, Shizuoka, Sunto-gun

329-0498

Jichi Medical University Hospital, Tochigi, Shimotsuke

113-8431

Juntendo University Hospital, Tokyo, Bunkyo-ku

104-0045

National Cancer Center Hospital, Tokyo, Chuo-ku

135-8550

Japanese Foundation for Cancer Research, Tokyo, Koto-ku

160-0023

Tokyo Medical University Hospital, Tokyo, Shinjuku-ku

641-8510

Wakayama Medical University Hospital, Wakayama, Wakayama

1066CX

Nederlands Kanker Instituut - Antoni van Leeuwenhoek Amsterdam (METC AVL), Amsterdam

1350-352

Hospital CUF Tejo, Lisbon

1500-650

Hospital da Luz, Lisbon

4100-180

Hospital CUF Porto, Porto

4200-072

IPO Porto Francisco Gentil, EPE, Porto

012292

Lotus Med, Bucharest

013823

Memorial Healthcare International, Bucharest

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08003

Hospital del Mar, Barcelona

08035

Hospital Vall Hebron, Barcelona

03203

Hospital General Universitario de Elche, Elche

08908

Hospital Duran i Reynals, L'Hospitalet de Llobregat

413 46

Sahlgrenska Universitetsjukhuset, Gothenburg

171 76

Karolinska Universitetssjukhuset Solna, Stockholm

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY