Sucralose and Glucose Metabolism in Young Healthy Adults

NACompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

March 16, 2022

Primary Completion Date

June 12, 2024

Study Completion Date

June 12, 2024

Conditions
Glucose IntoleranceGlucose and Insulin ResponseGlucose HomeostasisLow-grade InflammationIntestinal PermeabilityGut Microbiota Diversity and CompositionGut Microbiota ModulationGut Microbiota DysbiosisGut MicrobiotaGut Microbiota Dysbiosis and NutritionInsulin ResistanceInsulin Sensitivity/ResistanceInsulin Sensitivity
Interventions
OTHER

Low-calorie sweeteners (LCS)

"Consumption of sucralose-sweetened beverages (LCS) using doses and formulations reflecting real-world conditions.~Individualized dose equivalent volume (mL) to SSB group. Average dose received of 150 mg (±30 mg) of pure sucralose per day (2.00 ± 0.23 mg/Kg BW) among participants, which is below Acceptable Daily Intake for sucralose (5 mg/Kg BW/day). LCS matched for sweetness to SSB based on the manufacturer's information."

OTHER

Refined sugars (SSB)

"Consumption of sugar-sweetened beverages (SSB) using doses and formulations reflecting real-world conditions.~Individualized dose of 15% Ereq representing estimated free sugars consumption in Canada. SSB matched total free sugar concentration of 100% natural orange juice (FJ)."

OTHER

Natural sugars (FJ)

"Consumption of natural fruit juice (100% natural orange juice) using doses and formulations reflecting real-world conditions.~Individualized dose of 15% Ereq representing estimated free sugars consumption in Canada."

Trial Locations (1)

K1S 5S9

Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa

All Listed Sponsors
lead

University of Ottawa

OTHER