Remiazolam vs Propofol Total Intravenous Anesthesia on Postoperative Neurodevelopment After General Anesthesia in Children

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

558

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

October 1, 2030

Study Completion Date

October 1, 2030

Conditions
Adenotonsillar Hypertrophy
Interventions
DRUG

Remimazolam based total intravenous anesthesia

For patients who aged between 3 and 6 years old undergoing tonsillectomy or/and adenoidectomy, anesthesia induction will performed with remimazolam in a dose of 0.4 - 0.5 mg/kg anesthesia maintenance was administered with remimazolam at a rate of 1.0 - 3.0 mg/kg/h.

DRUG

Propofol based general anesthesia

For patients who aged between 3 and 6 years old undergoing tonsillectomy or/and adenoidectomy, anesthesia induction will performed with propofol in a dose of 2.0 - 3.5 mg/kg , anesthesia maintenance was administered with propofol at a rate of 4 - 12 mg/kg/h.

All Listed Sponsors
lead

The First Affiliated Hospital of Anhui Medical University

OTHER