Stupp Treatment With Intrathecal Injection of Thiotepa for Glioblastoma With Advanced Spread

Intrathecal injection of thiotepa: Administered via lumbar puncture or OMMAYA reservoir according to the study protocol.

Stupp regimen (oral temozolomide)::75 mg/m² daily during radiotherapy; 150-200 mg/m² daily for 5 days every 28 days for 6 cycles after radiotherapy;

Radical radiotherapy: Delivery of 60 Gy of radiation, typically divided into 30 fractions of 2 Gy each;

Maximal surgical resection: Removal of as much tumor as possible while preserving neurological function;