ECG-less Coronary Computed Tomography Angiography in the Management of Patients Presenting With High-troponin Chest Pain

NARecruitingINTERVENTIONAL
Enrollment

230

Participants

Timeline

Start Date

September 10, 2025

Primary Completion Date

September 30, 2027

Study Completion Date

March 31, 2028

Conditions
Chest PainAcute Coronary Syndromes (ACS)
Interventions
RADIATION

Non-ECG-gated computed tomography

Scanning with a Revolution Apex Elite system (GE Healthcare, WI, USA), using hyperdrive pulmonary CT angiography (523mm/s with 0.28s/rotation gantry speed). Images will be acquired using the ECG-less Cardiac software (GE Healthcare, WI, USA), without the need for patient-attached ECG leads. The system uses a wide detector coverage of 160mm to provide full heart coverage and a fast gantry speed of 0.23 seconds per rotation to perform imaging in a single cardiac cycle. An estimation of the heart rhythm must be provided, based on the heart rhythm the scanner simulates an ECG signal. This simulated ECG signal provides virtual gating of the scan. Advanced software tools including SmartPhase (automated phase selection) and SnapShot Freeze 2 (optimized volume registration) will be used. After a short delay of 5-12 sec, allowing contrast to pass from the pulmonary circulation into the aorta and coronary arteries, a coronary CT angiography will be performed using the same contrast bolus.

Trial Locations (1)

1090

RECRUITING

Universitair Ziekenhuis Brussel, Jette

All Listed Sponsors
lead

Universitair Ziekenhuis Brussel

OTHER

NCT07192965 - ECG-less Coronary Computed Tomography Angiography in the Management of Patients Presenting With High-troponin Chest Pain | Biotech Hunter | Biotech Hunter