200
Participants
Start Date
October 31, 2025
Primary Completion Date
October 31, 2026
Study Completion Date
January 31, 2027
Restrictive intubation strategy
"Endotracheal intubation is recommended only if at least one of the following criteria persists for more than 5 minutes:~1. Respiratory rate \> 40/min, persistent use of accessory muscles, or thoracoabdominal paradox.~2. SpO₂/FiO₂ \< 88.~3. Neurological or systemic impairment attributable to hypoxemia, defined as: altered higher brain functions without another identifiable cause, Glasgow Coma Scale ≤ 12, uncontrolled hemodynamic instability, or rising lactate levels."
Liberal intubation strategy
"Endotracheal intubation is recommended if SpO₂/FiO₂ \< 110 for more than 5 minutes.~In addition, intubation is also recommended in the liberal strategy if any of the restrictive strategy criteria occur and persist for more than 5 minutes."
Angers University Hospital, ICU, Angers
Le Mans Hospital, ICU, Le Mans
Nantes University Hospital, ICU, Nantes
Orléans University hospital, ICU, Orléans
Pitié-Salpétrière Hospital, Paris University Hospital, ICU, Paris
Guadeloupe University Hospital, ICU, Pointe à Pitre
Rennes University Hospital, ICU, Rennes
Tours University Hospital, ICU, Tours
Vannes Hospital, ICU, Vannes
University Hospital, Angers
OTHER_GOV